ID F2CZT5_HORVV Unreviewed; 291 AA.
AC F2CZT5;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:BAJ88356.1};
OS Hordeum vulgare subsp. vulgare (Domesticated barley).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Hordeinae; Hordeum.
OX NCBI_TaxID=112509 {ECO:0000313|EMBL:BAJ88356.1};
RN [1] {ECO:0000313|EMBL:BAJ88356.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Shoot {ECO:0000313|EMBL:BAJ88356.1};
RX PubMed=21415278; DOI=10.1104/pp.110.171579;
RA Matsumoto T., Tanaka T., Sakai H., Amano N., Kanamori H., Kurita K.,
RA Kikuta A., Kamiya K., Yamamoto M., Ikawa H., Fujii N., Hori K., Itoh T.,
RA Sato K.;
RT "Comprehensive sequence analysis of 24,783 barley full-length cDNAs derived
RT from 12 clone libraries.";
RL Plant Physiol. 156:20-28(2011).
RN [2] {ECO:0000313|Proteomes:UP000011116}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Morex {ECO:0000313|Proteomes:UP000011116};
RX PubMed=23075845; DOI=10.1038/nature11543;
RG The International Barley Genome Sequencing Consortium;
RA Mayer K.F., Waugh R., Brown J.W., Schulman A., Langridge P., Platzer M.,
RA Fincher G.B., Muehlbauer G.J., Sato K., Close T.J., Wise R.P., Stein N.;
RT "A physical, genetic and functional sequence assembly of the barley
RT genome.";
RL Nature 491:711-716(2012).
RN [3] {ECO:0000313|EnsemblPlants:HORVU.MOREX.r3.6HG0569040.1}
RP IDENTIFICATION.
RC STRAIN=subsp. vulgare
RC {ECO:0000313|EnsemblPlants:HORVU.MOREX.r3.6HG0569040.1};
RG EnsemblPlants;
RL Submitted (JAN-2022) to UniProtKB.
CC -!- SIMILARITY: Belongs to the HIBADH-related family. NP60 subfamily.
CC {ECO:0000256|ARBA:ARBA00007598}.
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DR EMBL; AK357141; BAJ88356.1; -; mRNA.
DR EMBL; AK359959; BAJ91168.1; -; mRNA.
DR AlphaFoldDB; F2CZT5; -.
DR EnsemblPlants; HORVU.MOREX.r3.6HG0569040.1; HORVU.MOREX.r3.6HG0569040.1; HORVU.MOREX.r3.6HG0569040.
DR Gramene; HORVU.MOREX.r2.6HG0471630.1; HORVU.MOREX.r2.6HG0471630.1; HORVU.MOREX.r2.6HG0471630.
DR Gramene; HORVU.MOREX.r2.6HG0471630.1.mrna1; HORVU.MOREX.r2.6HG0471630.1.mrna1; HORVU.MOREX.r2.6HG0471630.1.
DR Gramene; HORVU.MOREX.r3.6HG0569040.1; HORVU.MOREX.r3.6HG0569040.1; HORVU.MOREX.r3.6HG0569040.
DR OMA; LHDKDFG; -.
DR OrthoDB; 103196at2759; -.
DR Proteomes; UP000011116; Chromosome 6H.
DR ExpressionAtlas; F2CZT5; baseline and differential.
DR GO; GO:0005829; C:cytosol; IEA:EnsemblPlants.
DR GO; GO:0003858; F:3-hydroxybutyrate dehydrogenase activity; IEA:EnsemblPlants.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0006979; P:response to oxidative stress; IEA:EnsemblPlants.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43580; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR PANTHER; PTHR43580:SF2; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE 2: Evidence at transcript level;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000011116}.
FT DOMAIN 2..158
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 164..283
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 170
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 291 AA; 30352 MW; 024E6419A636A285 CRC64;
MEVGFLGLGI MGKAMAANLL RHGFRVTVWN RTLSKCDELV AMGAAVGDTP ASVVAKCKYT
IAMLSDPSAA LSVVFDKDGV LEQIGEGKGY VDMSTVDAAT SCKISEAVKQ KGGAFVEAPV
SGSKKPAEDG QLVILAAGDK ALYDDMVPAF DILGKKSFFL GEMGNGAKMK LVVNMIMGSM
MNAFSEGLCL ADKSGLSPQT LLDVLDLGAI ANPMFKMKGP SMLQGSYNPA FPLKHQQKDM
RLALSLGDEN AVSMPVAAAA NEAFKKARSL GLGDLDFSAV HEVLKGTGGS G
//
