ID F2I5R4_AERUA Unreviewed; 573 AA.
AC F2I5R4; A0A9Q4DB35;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE RecName: Full=Septation ring formation regulator EzrA {ECO:0000256|HAMAP-Rule:MF_00728};
GN Name=ezrA {ECO:0000256|HAMAP-Rule:MF_00728,
GN ECO:0000313|EMBL:AEA01195.1};
GN OrderedLocusNames=HMPREF9243_1398 {ECO:0000313|EMBL:AEA01195.1};
GN ORFNames=ODY48_08140 {ECO:0000313|EMBL:MCY3055699.1};
OS Aerococcus urinae (strain CCUG 59500 / ACS-120-V-Col10a).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Aerococcaceae; Aerococcus;
OC Aerococcus incertae sedis.
OX NCBI_TaxID=2976812 {ECO:0000313|EMBL:AEA01195.1, ECO:0000313|Proteomes:UP000008129};
RN [1] {ECO:0000313|Proteomes:UP000008129}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ACS-120-V-Col10a {ECO:0000313|Proteomes:UP000008129};
RA Durkin A.S., Madupu R., Radune D., Hostetler J., Torralba M., Gillis M.,
RA Methe B., Sutton G., Nelson K.E.;
RT "Complete genome sequence of Aerococcus urinae strain ACS-120-V-Col10a.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AEA01195.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ACS-120-V-Col10a {ECO:0000313|EMBL:AEA01195.1};
RA Durkin A.S., Madupu R., Radune D., Hostetler J., Torralba M., Gillis M.,
RA Methe B., Sutton G., Nelson K.E.;
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:MCY3055699.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CDC-1656-U92 {ECO:0000313|EMBL:MCY3055699.1};
RA Christensen J., Senneby E.;
RT "Aerococcus urinae taxonomy study.";
RL Submitted (SEP-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negative regulator of FtsZ ring formation; modulates the
CC frequency and position of FtsZ ring formation. Inhibits FtsZ ring
CC formation at polar sites. Interacts either with FtsZ or with one of its
CC binding partners to promote depolymerization. {ECO:0000256|HAMAP-
CC Rule:MF_00728}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_00728};
CC Single-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_00728}.
CC Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}. Note=Colocalized with FtsZ to the
CC nascent septal site. {ECO:0000256|HAMAP-Rule:MF_00728}.
CC -!- SIMILARITY: Belongs to the EzrA family. {ECO:0000256|HAMAP-
CC Rule:MF_00728}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP002512; AEA01195.1; -; Genomic_DNA.
DR EMBL; JAOTMI010000030; MCY3055699.1; -; Genomic_DNA.
DR RefSeq; WP_013669430.1; NC_015278.1.
DR AlphaFoldDB; F2I5R4; -.
DR STRING; 866775.HMPREF9243_1398; -.
DR KEGG; aur:HMPREF9243_1398; -.
DR PATRIC; fig|866775.3.peg.1306; -.
DR eggNOG; COG4477; Bacteria.
DR HOGENOM; CLU_034079_2_0_9; -.
DR OMA; FRSQNHI; -.
DR Proteomes; UP000008129; Chromosome.
DR Proteomes; UP001075187; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005940; C:septin ring; IEA:InterPro.
DR GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR GO; GO:0000921; P:septin ring assembly; IEA:InterPro.
DR HAMAP; MF_00728; EzrA; 1.
DR InterPro; IPR010379; EzrA.
DR Pfam; PF06160; EzrA; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|HAMAP-Rule:MF_00728};
KW Cell division {ECO:0000256|HAMAP-Rule:MF_00728};
KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_00728};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|HAMAP-
KW Rule:MF_00728};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_00728};
KW Reference proteome {ECO:0000313|Proteomes:UP000008129};
KW Septation {ECO:0000256|ARBA:ARBA00023210, ECO:0000256|HAMAP-Rule:MF_00728};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_00728};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_00728}.
FT TOPO_DOM 1..5
FT /note="Extracellular"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
FT TRANSMEM 6..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TOPO_DOM 25..573
FT /note="Cytoplasmic"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
FT COILED 452..500
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
SQ SEQUENCE 573 AA; 66949 MW; 6AE251047F7B81EB CRC64;
MGFIIALIII IVIILIGYGL LYYLGRKQSK TNLELDEKKQ EIMAIPVADK LYTIRNKNVS
GNTRRLFEAE QAKWQTIKQY KLPEIEAALV QAQADADKFS LIKSRKTAEE TEKLIYDTLQ
DVQNINQSLE ELLASESKNE AYFQEINDRY AKIRKQLLAH GYAYGDSQET LEKHLSYIEL
DFTKYNTLMS DADYLAAHDV LDQTKEDIEA LEAMMEEIPK LLDKIDNEYE EQLEDLKSGY
SQMLDMDFQF PSGVRVDEEI QQVEKGIEQC YAALAECDLS ETSSLMSATE AQIDRSYELM
EVELRAKEYI EKNQGNLEQR INQVRQSNRY GSLEIDRVSQ NYLLHDNELG KLQDYAAQID
RIHEEVDTVN QRLGAHVIAY TDMQSVYKDK YEQLNEIDKA QSHIVGSLAN LRQKERDARD
MLYTFDLDMR NMKRRVNQYH LPGLPDAYLD RYFATEDKVE ELERKMNRVK LDMDEIDQLV
NEVSEAIERL DLETENMIDQ ALLTEQTVQY ANRYRANHPE LNQAIEKSSY YFNQTFDYKK
AHQTISQAVD QLESGASNKV ENQYRQEKEE RLY
//