ID F2IIX6_FLUTR Unreviewed; 874 AA.
AC F2IIX6;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN OrderedLocusNames=Fluta_0831 {ECO:0000313|EMBL:AEA42833.1};
OS Fluviicola taffensis (strain DSM 16823 / NCIMB 13979 / RW262).
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Crocinitomicaceae; Fluviicola.
OX NCBI_TaxID=755732 {ECO:0000313|EMBL:AEA42833.1, ECO:0000313|Proteomes:UP000007463};
RN [1] {ECO:0000313|EMBL:AEA42833.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 16823 {ECO:0000313|EMBL:AEA42833.1};
RX PubMed=22180807; DOI=10.4056/sigs.2124912;
RA Woyke T., Chertkov O., Lapidus A., Nolan M., Lucas S., Del Rio T.G.,
RA Tice H., Cheng J.F., Tapia R., Han C., Goodwin L., Pitluck S., Liolios K.,
RA Pagani I., Ivanova N., Huntemann M., Mavromatis K., Mikhailova N., Pati A.,
RA Chen A., Palaniappan K., Land M., Hauser L., Brambilla E.M., Rohde M.,
RA Mwirichia R., Sikorski J., Tindall B.J., Goker M., Bristow J., Eisen J.A.,
RA Markowitz V., Hugenholtz P., Klenk H.P., Kyrpides N.C.;
RT "Complete genome sequence of the gliding freshwater bacterium Fluviicola
RT taffensis type strain (RW262).";
RL Stand. Genomic Sci. 5:21-29(2011).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; CP002542; AEA42833.1; -; Genomic_DNA.
DR RefSeq; WP_013685605.1; NC_015321.1.
DR AlphaFoldDB; F2IIX6; -.
DR STRING; 755732.Fluta_0831; -.
DR KEGG; fte:Fluta_0831; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_3_1_10; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000007463; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000007463}.
FT DOMAIN 694..710
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 620..627
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 874 AA; 98373 MW; 7C4935354B2FCC27 CRC64;
MSKKEKGPAE TPLMKQYNEI KAKHPQALLL FRVGDFYETF GEDAITASKT LGIILTKRGA
GSPSEIELAG FPHHSLDTYL PKLVRAGHRV AICDQLEDPK MTKTIVKRGV TELVTPGIAF
SDKILDGHHN NFLGAIHFGK EIHGIAFLDV TTGEFFTAQG NTEYITKLIQ GFEPSEIIYQ
KNKHSLFQEL FGTKYYTFRL DDWIFTPDFG KERLTNHFKT NSMKGFGIDD LEYGIIASGA
ILHYLGETQH DKLGHITQIQ RIEEEKYVWL DRFTIRNLEL IAPLNEGGKT LFNVINGTKT
PMGDRLLKRW IVMPLKHEEQ INLRIDAVAD LTDKHSLRAE IEHELNEIGD MERLISKVAV
GKIHPKELRV LSRILEHMVP LRDACSHSVS NLLQQLSQRL EPCEEFIQLV ERMLLKDPAV
MLGKGPVIAN GVHSELDELR AISESGKDYL EAMQERESEK TGIPSLKIAF NNVFGYYLEV
RNTHKDKVPE EWIRKQTLVS AERYITPELK EYETKILGAE DKISAIEAKL YFELVQKLSA
FVGAIQRNAF LIAQLDCLTG FADLAIRNNY SKPTINDSYV IDIKNGRHPV IEGQLKAGVE
YVPNDVYLDK EEQQIIMITG PNMSGKSALL RQTALIVLMA QMGSFIPADA AILGIVDKVF
TRVGASDNIS SGESTFMVEM NETSSILNNL SDRSLILLDE IGRGTSTYDG ISIAWAIAEF
IHEFPQAKGK TLFATHYHEL NEMAVQFPRI HNYNVSVKEV GQKIIFLRKL VEGGSEHSFG
IHVAKLAGMP TKVIQRAELM LEQLELNHRS SEMKNVKDVV IQAGASNDMQ LSFFQLNDPV
LEQIHDQLIS IDINTLTPVE ALMKLNEIKK LTGG
//
