ID F2IYJ8_POLGS Unreviewed; 319 AA.
AC F2IYJ8;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=uroporphyrinogen decarboxylase {ECO:0000256|ARBA:ARBA00012288};
DE EC=4.1.1.37 {ECO:0000256|ARBA:ARBA00012288};
GN Name=hemE {ECO:0000313|EMBL:ADZ68511.1};
GN OrderedLocusNames=SL003B_0072 {ECO:0000313|EMBL:ADZ68511.1};
OS Polymorphum gilvum (strain LMG 25793 / CGMCC 1.9160 / SL003B-26A1).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Polymorphum.
OX NCBI_TaxID=991905 {ECO:0000313|EMBL:ADZ68511.1, ECO:0000313|Proteomes:UP000008130};
RN [1] {ECO:0000313|EMBL:ADZ68511.1, ECO:0000313|Proteomes:UP000008130}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMG 25793 / CGMCC 1.9160 / SL003B-26A1
RC {ECO:0000313|Proteomes:UP000008130};
RX PubMed=21478361; DOI=10.1128/JB.00333-11;
RA Li S.G., Tang Y.Q., Nie Y., Cai M., Wu X.L.;
RT "Complete genome sequence of Polymorphum gilvum SL003B-26A1T, a crude oil-
RT degrading bacterium from oil-polluted saline soil.";
RL J. Bacteriol. 193:2894-2895(2011).
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.
CC {ECO:0000256|ARBA:ARBA00004804}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the uroporphyrinogen decarboxylase family.
CC {ECO:0000256|ARBA:ARBA00009935}.
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DR EMBL; CP002568; ADZ68511.1; -; Genomic_DNA.
DR AlphaFoldDB; F2IYJ8; -.
DR STRING; 991905.SL003B_0072; -.
DR KEGG; pgv:SL003B_0072; -.
DR PATRIC; fig|991905.3.peg.75; -.
DR eggNOG; COG0407; Bacteria.
DR HOGENOM; CLU_040933_0_0_5; -.
DR UniPathway; UPA00251; UER00321.
DR Proteomes; UP000008130; Chromosome.
DR GO; GO:0004853; F:uroporphyrinogen decarboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00717; URO-D; 1.
DR Gene3D; 3.20.20.210; -; 1.
DR InterPro; IPR038071; UROD/MetE-like_sf.
DR InterPro; IPR006361; Uroporphyrinogen_deCO2ase_HemE.
DR InterPro; IPR000257; Uroporphyrinogen_deCOase.
DR NCBIfam; TIGR01464; hemE; 1.
DR PANTHER; PTHR21091; METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED; 1.
DR PANTHER; PTHR21091:SF169; UROPORPHYRINOGEN DECARBOXYLASE; 1.
DR Pfam; PF01208; URO-D; 1.
DR SUPFAM; SSF51726; UROD/MetE-like; 1.
DR PROSITE; PS00907; UROD_2; 1.
PE 3: Inferred from homology;
KW Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW Reference proteome {ECO:0000313|Proteomes:UP000008130}.
FT DOMAIN 116..132
FT /note="Uroporphyrinogen decarboxylase (URO-D)"
FT /evidence="ECO:0000259|PROSITE:PS00907"
SQ SEQUENCE 319 AA; 34961 MW; 1629E99103E95936 CRC64;
MMRQAGRYLP EYREARAKAP NFLDFCYNPD LATEVTLQPI RRYGFDASIL FSDIFVVPDA
IGYPVRFEEG RGPVLEPLSA KLVDGLEQGR AEAHLEPVIE TVRRLRAQLP GETTLLGFCG
APWTVACYSV AGHTTQDQTA ARIGSYRDPA LLGRFIDQLV TASIQYLVRQ LEAGADAVQI
FDTWAGVLDE DGFRRWCIEP TRAIVAGVKA QRPEAKVIGF PKASAARLES YIDGTGIDAV
GLDWTVPDTL ARTVQRRVPV QGNLDPMRLV AGGKALDDGI DRVLSALGEG PLIFNLGHGV
TPETDPDNVA RMVERVRRG
//
