ID F2LB12_BURGS Unreviewed; 446 AA.
AC F2LB12;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Efflux transporter, RND family, MFP subunit {ECO:0000313|EMBL:AEA59844.1};
GN OrderedLocusNames=bgla_1g11620 {ECO:0000313|EMBL:AEA59844.1};
OS Burkholderia gladioli (strain BSR3).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia.
OX NCBI_TaxID=999541 {ECO:0000313|EMBL:AEA59844.1, ECO:0000313|Proteomes:UP000008316};
RN [1] {ECO:0000313|EMBL:AEA59844.1, ECO:0000313|Proteomes:UP000008316}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BSR3 {ECO:0000313|EMBL:AEA59844.1,
RC ECO:0000313|Proteomes:UP000008316};
RX PubMed=21478339; DOI=10.1128/JB.00420-11;
RA Seo Y.S., Lim J., Choi B.S., Kim H., Goo E., Lee B., Lim J.S., Choi I.Y.,
RA Moon J.S., Kim J., Hwang I.;
RT "Complete genome sequence of Burkholderia gladioli BSR3.";
RL J. Bacteriol. 193:3149-3149(2011).
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP002599; AEA59844.1; -; Genomic_DNA.
DR RefSeq; WP_013697195.1; NC_015381.1.
DR AlphaFoldDB; F2LB12; -.
DR STRING; 999541.bgla_1g11620; -.
DR KEGG; bgd:bgla_1g11620; -.
DR eggNOG; COG0845; Bacteria.
DR HOGENOM; CLU_018816_2_0_4; -.
DR Proteomes; UP000008316; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30469; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR PANTHER; PTHR30469:SF12; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR Pfam; PF13533; Biotin_lipoyl_2; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 28..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 106..154
FT /note="Membrane fusion protein biotin-lipoyl like"
FT /evidence="ECO:0000259|Pfam:PF13533"
FT DOMAIN 204..328
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 53..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 446 AA; 47117 MW; 9ED42C85688462C5 CRC64;
MNNQESQTPR SPATPPQDPA PRKRRRPIAI GVAALVVIGG ALLWWHPWKK NEAPANGQQA
GQGGGRRHGG PADFANQPQP VQVATASRGE MPIVLSALGT VTPLATVTVK TQLSGYLQSV
NFTEGQMVKK GDVLVQIDPR PYQVALETAE GTLARDQALL ATARLDLKRY QTLLAQDSIS
GQQADTQASL VKQYEGTVKT DQASIDSAKL NLTYARVTAP VSGRVGLRQV DAGNYVTPGD
TNGLVVITQL QPMSVIFTTS EDNLPPILKQ VNAGQSLSVT AYNRNNTVPL ETGSLETFDN
QIDTTTGTVK LRAIFANKNN LLFPNQFVNA RLLVDTLKDA VIVPTAAVQT GSIGQFVYIV
KPDNTVTVRK VKPGPVDGER TSIAEGVQVG ERVVTDGVDR LREGAKITIP AEHPAGASGA
SAAHAASGAS GAHGHRHHGA SQSAAQ
//
