ID F2LDS5_BURGS Unreviewed; 694 AA.
AC F2LDS5;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase, NAD-binding protein {ECO:0000313|EMBL:AEA61000.1};
GN OrderedLocusNames=bgla_1g23730 {ECO:0000313|EMBL:AEA61000.1};
OS Burkholderia gladioli (strain BSR3).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia.
OX NCBI_TaxID=999541 {ECO:0000313|EMBL:AEA61000.1, ECO:0000313|Proteomes:UP000008316};
RN [1] {ECO:0000313|EMBL:AEA61000.1, ECO:0000313|Proteomes:UP000008316}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BSR3 {ECO:0000313|EMBL:AEA61000.1,
RC ECO:0000313|Proteomes:UP000008316};
RX PubMed=21478339; DOI=10.1128/JB.00420-11;
RA Seo Y.S., Lim J., Choi B.S., Kim H., Goo E., Lee B., Lim J.S., Choi I.Y.,
RA Moon J.S., Kim J., Hwang I.;
RT "Complete genome sequence of Burkholderia gladioli BSR3.";
RL J. Bacteriol. 193:3149-3149(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
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DR EMBL; CP002599; AEA61000.1; -; Genomic_DNA.
DR RefSeq; WP_013698328.1; NC_015381.1.
DR AlphaFoldDB; F2LDS5; -.
DR STRING; 999541.bgla_1g23730; -.
DR KEGG; bgd:bgla_1g23730; -.
DR eggNOG; COG1024; Bacteria.
DR eggNOG; COG1250; Bacteria.
DR HOGENOM; CLU_009834_16_3_4; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000008316; Chromosome 1.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-KW.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23309; 3-HYDROXYACYL-COA DEHYROGENASE; 1.
DR PANTHER; PTHR23309:SF9; PEROXISOMAL BIFUNCTIONAL ENZYME; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140}.
FT DOMAIN 295..471
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 476..568
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 604..690
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 694 AA; 74515 MW; E1D554673F80811A CRC64;
MAVDYTTRDG VAVITLNNPP VNGLGYSTRV GVMDGLDRAL QDPAVTAIVL TGAGRAFSGG
ADITEFNTPK ALQEPSLHTL IAAVEASAKP VVAAVHSVVM GGGLELALGA HYRIAAPGTQ
VALPEVKIGL LPGAGGTQRL PRALGLETAL NMIVSGAAVP SEQLAKSGLF DEMAEGDLLE
AAVALARRVG AKPGPHPRVR DRKIEHPNAA GFIQFARNSA RAAAPQYPAP HKCIDAIEAG
VLKGFDQGLI DEREGFVALV QTPESRALRH AFFGERAASK IPDVPADTPV REIRKLGVIG
AGTMGGGITI NFLNAGLPVT LLETKQEALE RGLATIRKNY EVQVKKGKLS EEKLEARMAL
ISPTLSYEDL KDADLIIEAV FEELGVKEQV FRKLDEVAKP GAILASNTST LDVNKIAAFT
RRPQDVVGMH FFSPANVMKL LEVVRGEHTA KDVLATVMQL AKKIRKTAVV SGVCDGFIGN
RMVEQYIRQA LFMLEEGALP AQVDRAIEAF GFAMGPFRMS DLAGNDIGWA IRKRRYLEQP
ELHYSKIADR LCELGRFGQK TGGGWYDYQA GERRAKPSKL VDEMVLAYSK EAGVERRKIA
DEEIVERLVY ALVNEGAKIL EEGIASKASD IDMVYLTGYG FPLWRGGPML YADTVGLYNV
ERAMRRYAAG ANGDAWQPAP SIAKLAAAGK GFNG
//
