ID F2NLB0_MARHT Unreviewed; 627 AA.
AC F2NLB0;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Glutamine amidotransferase of anthranilate synthase {ECO:0000313|EMBL:AEB11729.1};
DE EC=4.1.3.27 {ECO:0000313|EMBL:AEB11729.1};
GN OrderedLocusNames=Marky_0986 {ECO:0000313|EMBL:AEB11729.1};
OS Marinithermus hydrothermalis (strain DSM 14884 / JCM 11576 / T1).
OC Bacteria; Deinococcota; Deinococci; Thermales; Thermaceae; Marinithermus.
OX NCBI_TaxID=869210 {ECO:0000313|EMBL:AEB11729.1, ECO:0000313|Proteomes:UP000007030};
RN [1] {ECO:0000313|EMBL:AEB11729.1, ECO:0000313|Proteomes:UP000007030}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14884 / JCM 11576 / T1 {ECO:0000313|Proteomes:UP000007030};
RX PubMed=22675595; DOI=10.4056/sigs.2435521;
RA Copeland A., Gu W., Yasawong M., Lapidus A., Lucas S., Deshpande S.,
RA Pagani I., Tapia R., Cheng J.F., Goodwin L.A., Pitluck S., Liolios K.,
RA Ivanova N., Mavromatis K., Mikhailova N., Pati A., Chen A., Palaniappan K.,
RA Land M., Pan C., Brambilla E.M., Rohde M., Tindall B.J., Sikorski J.,
RA Goker M., Detter J.C., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA Kyrpides N.C., Klenk H.P., Woyke T.;
RT "Complete genome sequence of the aerobic, heterotroph Marinithermus
RT hydrothermalis type strain (T1(T)) from a deep-sea hydrothermal vent
RT chimney.";
RL Stand. Genomic Sci. 6:21-30(2012).
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DR EMBL; CP002630; AEB11729.1; -; Genomic_DNA.
DR RefSeq; WP_013703777.1; NC_015387.1.
DR AlphaFoldDB; F2NLB0; -.
DR STRING; 869210.Marky_0986; -.
DR MEROPS; C26.955; -.
DR KEGG; mhd:Marky_0986; -.
DR eggNOG; COG0147; Bacteria.
DR eggNOG; COG0512; Bacteria.
DR HOGENOM; CLU_006493_5_0_0; -.
DR OrthoDB; 9803598at2; -.
DR Proteomes; UP000007030; Chromosome.
DR GO; GO:0004049; F:anthranilate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd01743; GATase1_Anthranilate_Synthase; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR Gene3D; 3.60.120.10; Anthranilate synthase; 1.
DR InterPro; IPR005801; ADC_synthase.
DR InterPro; IPR019999; Anth_synth_I-like.
DR InterPro; IPR015890; Chorismate_C.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR017926; GATASE.
DR InterPro; IPR006221; TrpG/PapA_dom.
DR NCBIfam; TIGR00566; trpG_papA; 1.
DR PANTHER; PTHR11236; AMINOBENZOATE/ANTHRANILATE SYNTHASE; 1.
DR PANTHER; PTHR11236:SF9; ANTHRANILATE SYNTHASE COMPONENT 1; 1.
DR Pfam; PF00425; Chorismate_bind; 1.
DR Pfam; PF00117; GATase; 1.
DR PRINTS; PR00097; ANTSNTHASEII.
DR PRINTS; PR00099; CPSGATASE.
DR PRINTS; PR00096; GATASE.
DR SUPFAM; SSF56322; ADC synthase; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
DR PROSITE; PS51273; GATASE_TYPE_1; 1.
PE 4: Predicted;
KW Glutamine amidotransferase {ECO:0000256|PROSITE-ProRule:PRU00605,
KW ECO:0000313|EMBL:AEB11729.1}; Lyase {ECO:0000313|EMBL:AEB11729.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007030}.
FT DOMAIN 150..401
FT /note="Chorismate-utilising enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00425"
FT DOMAIN 442..618
FT /note="Glutamine amidotransferase"
FT /evidence="ECO:0000259|Pfam:PF00117"
FT ACT_SITE 514
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 601
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 603
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
SQ SEQUENCE 627 AA; 68561 MW; 9C524944D692B4A6 CRC64;
MEALGLYRRA RALGLRPALL ESLGPRTAFG RRTLLGLRPT RRLEVWGGVL YEDGRLVGTA
LDLLERLEEG LGEGHFPAWI GFFAYEFARH LGLPARAPMP GLPEAAFCYY PEGYVWEDGR
LVEAPSVLLE VDPGMPVGLP EVRLVSDYPR EAFIAGVQAV QERIRAGWVY QVNLSHRFRF
PAVGLDPLDY YAALRRTNPS PFMGLVEGAG WAVVSGSPER LFALREGVLS ARPIAGTRRR
GRTPEEDQAL EAELRANVKE RAEHVMLVDL LRNDLSRVAE PGTVEVSEAF TVERYSHVMH
LVSEVRGVSR AGVGAALRAI FPGGTITGAP KESVMQAIAE LEPVPRGAYT GSLGYVSGRG
ADFNILIRSL TLAGGWAYLS AGAGIVIESD PVREYEETRH KAEALLYVLG QGRPGVRPEP
PRVIEAWRPP RPRRRYAARV VFLENHDSFS YNLVNYLRML GAEVRVVDHG EPPALGGATH
LVVGPGPGDP FTAGRTLEWV RAALEDGVPF LGVCLGHQAL GVALGAVLER APRPVHGEAH
PVRHVGRGVF AGLPDPAPFT RYHSLHLRDL PPVLERLAWT EDGVVMGVGH RSRPAWGVQF
HPESMLSPYG LELLANFLEV RGAAGDR
//
