ID   F2NPP4_MARHT            Unreviewed;       602 AA.
AC   F2NPP4;
DT   31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   31-MAY-2011, sequence version 1.
DT   27-MAR-2024, entry version 53.
DE   SubName: Full=CBS domain and cyclic nucleotide-regulated nucleotidyltransferase {ECO:0000313|EMBL:AEB12545.1};
GN   OrderedLocusNames=Marky_1813 {ECO:0000313|EMBL:AEB12545.1};
OS   Marinithermus hydrothermalis (strain DSM 14884 / JCM 11576 / T1).
OC   Bacteria; Deinococcota; Deinococci; Thermales; Thermaceae; Marinithermus.
OX   NCBI_TaxID=869210 {ECO:0000313|EMBL:AEB12545.1, ECO:0000313|Proteomes:UP000007030};
RN   [1] {ECO:0000313|EMBL:AEB12545.1, ECO:0000313|Proteomes:UP000007030}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14884 / JCM 11576 / T1 {ECO:0000313|Proteomes:UP000007030};
RX   PubMed=22675595; DOI=10.4056/sigs.2435521;
RA   Copeland A., Gu W., Yasawong M., Lapidus A., Lucas S., Deshpande S.,
RA   Pagani I., Tapia R., Cheng J.F., Goodwin L.A., Pitluck S., Liolios K.,
RA   Ivanova N., Mavromatis K., Mikhailova N., Pati A., Chen A., Palaniappan K.,
RA   Land M., Pan C., Brambilla E.M., Rohde M., Tindall B.J., Sikorski J.,
RA   Goker M., Detter J.C., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P., Woyke T.;
RT   "Complete genome sequence of the aerobic, heterotroph Marinithermus
RT   hydrothermalis type strain (T1(T)) from a deep-sea hydrothermal vent
RT   chimney.";
RL   Stand. Genomic Sci. 6:21-30(2012).
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DR   EMBL; CP002630; AEB12545.1; -; Genomic_DNA.
DR   RefSeq; WP_013704591.1; NC_015387.1.
DR   AlphaFoldDB; F2NPP4; -.
DR   STRING; 869210.Marky_1813; -.
DR   KEGG; mhd:Marky_1813; -.
DR   eggNOG; COG2905; Bacteria.
DR   HOGENOM; CLU_027866_1_0_0; -.
DR   OrthoDB; 9810963at2; -.
DR   Proteomes; UP000007030; Chromosome.
DR   GO; GO:0008773; F:[protein-PII] uridylyltransferase activity; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   CDD; cd04587; CBS_pair_CAP-ED_NT_Pol-beta-like_DUF294_assoc; 1.
DR   CDD; cd05401; NT_GlnE_GlnD_like; 1.
DR   Gene3D; 3.10.580.10; CBS-domain; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR018821; DUF294_put_nucleoTrafse_sb-bd.
DR   InterPro; IPR005105; GlnD_Uridyltrans_N.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   PANTHER; PTHR48108:SF6; CBS DOMAIN-CONTAINING PROTEIN CBSX1, CHLOROPLASTIC; 1.
DR   PANTHER; PTHR48108; CBS DOMAIN-CONTAINING PROTEIN CBSX2, CHLOROPLASTIC; 1.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF03445; DUF294; 1.
DR   Pfam; PF10335; DUF294_C; 1.
DR   SMART; SM00116; CBS; 2.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR   SUPFAM; SSF81593; Nucleotidyltransferase substrate binding subunit/domain; 1.
DR   PROSITE; PS51371; CBS; 2.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007030}.
FT   DOMAIN          12..111
FT                   /note="Cyclic nucleotide-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50042"
FT   DOMAIN          152..209
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
FT   DOMAIN          215..271
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
SQ   SEQUENCE   602 AA;  65968 MW;  BB5D1D8482DAFD6C CRC64;
     MEPLEFLKRT PPFDALPPEV LDRVAEGLEV VYHPAGTRVL VRGGAPSRYL YVIRKGAVRL
     ERAGRVALHL EEGEVFGYPS LLSGEPPAFD VVVEEDLLAY RVRREVFARL LEHPAFAAFF
     LKGLAERLKE VPVFPAPSSL GGLDFSQPVR RLVRGPPVFV PAEATVGEAA RRMREHRISS
     VLVAGEALGI LTDRDLRNRV LARGLGAATP VRAVMTAPAK TLPAGSSVFE ALEFMLAEGV
     HHLPLVEGER VVGVVTDTDL LRHQAKNPLY LLRRLERTRD PEGLEGYALE LAGVVEALLA
     GGLGVREIGR SVSALNDTLL RVLLRLAERR LGPPPVPYAW VVLGSEGRAE QLLLTDQDNA
     LVYAEASPEA QAYFARLAED VVQGLLRAGF PPCPGGYMAT RWRYPLEAWR ARFQRWVAAP
     DPQALLEAGI FFDFRAVHGG LSLEPLEAVL AEAADQRRFL AHLARAALAF RPPLTLFRRI
     REEEGGVDVK RGGIAPIVGL ARVYALEARA RARNTLERLE AARQAGVLSA AGAEVLAEAF
     GFLQKLRLRA QLVALGRGEA VGNRVRLEAL SPLERRHLKE AFLAVREAQE AAALRYQTAW
     LG
//