ID F2PHQ0_TRIEC Unreviewed; 878 AA.
AC F2PHQ0;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=DNA mismatch repair protein Msh4 {ECO:0000313|EMBL:EGE01462.1};
GN ORFNames=TEQG_00512 {ECO:0000313|EMBL:EGE01462.1};
OS Trichophyton equinum (strain ATCC MYA-4606 / CBS 127.97) (Horse ringworm
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=559882 {ECO:0000313|Proteomes:UP000009169};
RN [1] {ECO:0000313|Proteomes:UP000009169}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4606 / CBS 127.97 {ECO:0000313|Proteomes:UP000009169};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
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DR EMBL; DS995719; EGE01462.1; -; Genomic_DNA.
DR AlphaFoldDB; F2PHQ0; -.
DR VEuPathDB; FungiDB:TEQG_00512; -.
DR eggNOG; KOG0220; Eukaryota.
DR HOGENOM; CLU_002472_7_3_1; -.
DR Proteomes; UP000009169; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR PANTHER; PTHR11361:SF21; MUTS PROTEIN HOMOLOG 4; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 619..635
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 789..878
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 805..823
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 824..878
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 878 AA; 98441 MW; A21AF4EA047927B4 CRC64;
MQSRIPSTPL YPFTSDTRST RPGTSRTAAG GYRVTRPTTA ATTAVSQEII CAISESRGIS
PAVGLAFVNL STSEAVLSQI CDSQTYARTV HKLAVFEPTE VLFMNTSKEP LSKLYAIVEE
NLPHIRTVTV DRKHWSEQNC HDYVERLAFK EDTETIKMAL EGSYFSACCF AAVLSYIELE
LLVTFAPHSL RLRYEPSEGS MMIDLATIVS LELIQNLQNA KSKDCLFGIL NETLTPMGAR
LLRSNILQPS TEISKLNTRY DAVEELSSNE GMFFAVRQAL KSFVDSDRVL TALTVIPTKP
SFLFAEQSIN NVIMLKTFLC SPRNYEPVQT ILKETLNDDV RYQTSALDLR NHRTYAVKAG
VNNLLDVARQ TYKEANDDVL ELCARLTEEY DIPLDLRFES GRHYYFRVRS TDLKGVMLPD
IFINVYRKKA YVEFQTLDLV KMNQKITDSH NEVVSMSDQS IQELIDDARS QISSLFRISE
AVALLDMIAA FAYLQTIQDY VRPEITDTLA IKAGRHPIRE KIHSTKYIPN DVYASSQSRF
QIITGCNMSG KSTYIRSLAL MAVMAQIGSS VPAQYASFPV VHQLFARVST DDNQATNVST
FSTEMREMAF ILRNVDSKSM VIIDELGRGT ASTDGLAISI AIAEALLETH ALVWFTTHFH
DLPRIMEHRS GVINLHLAVD MSDPRSKITM LYKIVDGYVQ EQHYGLALAR IFSLPPYLIG
VAEEVSNHLA LAAQNRAKSP AVISLAKRRR LLLTLGEQLR HAHEGTMEDE ALREWLLRLQ
REFTLRMTDI EAETESNMGD GETSTPEPRE IEASQDDNEH VEAQSRLSSQ SFPIMPIDST
SNLERPRGSA SHSFGNSELL LNSDSGELDT NHSCTSNE
//
