ID F2PSG8_TRIEC Unreviewed; 575 AA.
AC F2PSG8;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=NCS1 nucleoside transporter {ECO:0000313|EMBL:EGE04747.1};
GN ORFNames=TEQG_03920 {ECO:0000313|EMBL:EGE04747.1};
OS Trichophyton equinum (strain ATCC MYA-4606 / CBS 127.97) (Horse ringworm
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=559882 {ECO:0000313|Proteomes:UP000009169};
RN [1] {ECO:0000313|Proteomes:UP000009169}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4606 / CBS 127.97 {ECO:0000313|Proteomes:UP000009169};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the purine-cytosine permease (2.A.39) family.
CC {ECO:0000256|ARBA:ARBA00008974}.
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DR EMBL; DS995735; EGE04747.1; -; Genomic_DNA.
DR AlphaFoldDB; F2PSG8; -.
DR VEuPathDB; FungiDB:TEQG_03920; -.
DR eggNOG; KOG2466; Eukaryota.
DR HOGENOM; CLU_021555_3_0_1; -.
DR Proteomes; UP000009169; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd11482; SLC-NCS1sbd_NRT1-like; 1.
DR Gene3D; 1.10.4160.10; Hydantoin permease; 1.
DR InterPro; IPR001248; Pur-cyt_permease.
DR InterPro; IPR045225; Uracil/uridine/allantoin_perm.
DR PANTHER; PTHR30618:SF4; -; 1.
DR PANTHER; PTHR30618; NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER; 1.
DR Pfam; PF02133; Transp_cyt_pur; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 82..103
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 142..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 172..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 203..222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 283..303
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 333..352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 392..409
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 415..440
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 549..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..575
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 575 AA; 62781 MW; 04AD6C0A5CD121F1 CRC64;
MKATSQGTML RRLHHAVTLS SENSEAVSVW INDDIRPLPP SRRTWSTLTF VGWWSVWQLS
LTNWQLGAAL VASSLSVWQT MIAVILGRII AAIVAVMIGY IGAEWHIGFP VYSRVIWGIF
GAIVPTVVRI GLTIVGFAFQ SYTGGLCVSA ILAAIFPSFN GLQNTLPESA HVTTQQIIGW
ALFNIISIPM LYRRPERSEK LMIGMNVISF ASLLGIMIWS LSYAKGAGDL IHQSSNLQGS
SALGFGILQG TTTVVGTVSI ALTSQMDFSR FARKPSDQVF GQWFTFIIIG SVMPLFGCLT
SSATQKIYGE PLWNPPTILA MWLQRDYSST SRAAAFFAGL GLVSSQLALT VVDNGKFCPN
QNLVLSDIIN LGYSVGMDLS GLLPRYINIR RGCYVGLILG MALCPWELLA SAKTFVSVIS
SFSIFMAPLC GIHISDYWIV RQRRLKLSDL YHSRPNGIYY YTSGINWRST IPWLVGWVPL
LPGFIHSINP TIKMPVGIDR LYALGFPYGL LASMAVHTVI NRIFPPPGIG DIDKDDIFGT
FTPTEAAKLG VSPLGGDDDS DGNSAQSSGN RAEKV
//
