ID F2PTU6_TRIEC Unreviewed; 340 AA.
AC F2PTU6;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=4-dimethylallyltryptophan N-methyltransferase {ECO:0000256|ARBA:ARBA00039094};
DE EC=2.1.1.261 {ECO:0000256|ARBA:ARBA00039094};
GN ORFNames=TEQG_04469 {ECO:0000313|EMBL:EGE05314.1};
OS Trichophyton equinum (strain ATCC MYA-4606 / CBS 127.97) (Horse ringworm
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=559882 {ECO:0000313|Proteomes:UP000009169};
RN [1] {ECO:0000313|Proteomes:UP000009169}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4606 / CBS 127.97 {ECO:0000313|Proteomes:UP000009169};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine
CC = 4-(3-methylbut-2-enyl)-L-abrine + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:34435, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:58209, ChEBI:CHEBI:59789, ChEBI:CHEBI:67248;
CC EC=2.1.1.261; Evidence={ECO:0000256|ARBA:ARBA00036016};
CC -!- PATHWAY: Alkaloid biosynthesis; ergot alkaloid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005107}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC {ECO:0000256|ARBA:ARBA00008361}.
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DR EMBL; DS995738; EGE05314.1; -; Genomic_DNA.
DR AlphaFoldDB; F2PTU6; -.
DR VEuPathDB; FungiDB:TEQG_04469; -.
DR eggNOG; ENOG502SISP; Eukaryota.
DR HOGENOM; CLU_049766_0_0_1; -.
DR Proteomes; UP000009169; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0009820; P:alkaloid metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR019257; MeTrfase_dom.
DR InterPro; IPR017804; MeTrfase_EgtD-like.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR017805; SAM_MeTrfase_EasF-type_put.
DR NCBIfam; TIGR03439; methyl_EasF; 1.
DR PANTHER; PTHR43397; ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1; 1.
DR PANTHER; PTHR43397:SF1; ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1; 1.
DR Pfam; PF10017; Methyltransf_33; 1.
DR PIRSF; PIRSF018005; UCP018005; 1.
PE 3: Inferred from homology;
KW Alkaloid metabolism {ECO:0000256|ARBA:ARBA00022589};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 23..336
FT /note="Histidine-specific methyltransferase SAM-dependent"
FT /evidence="ECO:0000259|Pfam:PF10017"
SQ SEQUENCE 340 AA; 38209 MW; 081C68CBBCE49EEB CRC64;
MGSINPPQIL DIRRSKFEES IPKQVEAGLL SSPKTLPALL FYSTEGIQHW NRHSHASDFY
PRHEEIQILK DKATDMAASI ADGSVVVDLG SASLDKVIHL LEALEAAQKK VTYYALDLSF
SELNSTLKAI PTDQFVHVQF SALHGTFDDG LQWLKETPFI RDQPHCLLLF GLTIGNFSRP
NAAKFLHNIA SYALVESPSH SSILLTLDSC KVPTKVIRAY TAEGVVPFAL ESLKYGNTLF
HQDVGENVFD PEDWYFLSEW NYVLGRHEAS LVPRSKDIKL GRPLDKIVVG KHEKVRFGCS
YKYDSGERKE LFETAGLRDV KSWSKEGCDV AFYQLKCCPN
//
