ID F2PXA1_TRIEC Unreviewed; 768 AA.
AC F2PXA1;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EGE06519.1};
GN ORFNames=TEQG_05519 {ECO:0000313|EMBL:EGE06519.1};
OS Trichophyton equinum (strain ATCC MYA-4606 / CBS 127.97) (Horse ringworm
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=559882 {ECO:0000313|Proteomes:UP000009169};
RN [1] {ECO:0000313|Proteomes:UP000009169}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4606 / CBS 127.97 {ECO:0000313|Proteomes:UP000009169};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
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DR EMBL; DS995748; EGE06519.1; -; Genomic_DNA.
DR AlphaFoldDB; F2PXA1; -.
DR VEuPathDB; FungiDB:TEQG_05519; -.
DR eggNOG; KOG2519; Eukaryota.
DR HOGENOM; CLU_007575_0_1_1; -.
DR Proteomes; UP000009169; Unassembled WGS sequence.
DR GO; GO:0008821; F:crossover junction DNA endonuclease activity; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProt.
DR CDD; cd09906; H3TH_YEN1; 1.
DR CDD; cd09870; PIN_YEN1; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 2.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR041177; GEN1_C.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR006086; XPG-I_dom.
DR InterPro; IPR006084; XPG/Rad2.
DR InterPro; IPR006085; XPG_DNA_repair_N.
DR InterPro; IPR037316; Yen1_H3TH.
DR PANTHER; PTHR11081:SF71; ENDONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13260)-RELATED; 1.
DR PANTHER; PTHR11081; FLAP ENDONUCLEASE FAMILY MEMBER; 1.
DR Pfam; PF18380; GEN1_C; 1.
DR Pfam; PF00867; XPG_I; 1.
DR Pfam; PF00752; XPG_N; 1.
DR PRINTS; PR00853; XPGRADSUPER.
DR SMART; SM00484; XPGI; 1.
DR SMART; SM00485; XPGN; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722}.
FT DOMAIN 1..101
FT /note="XPG N-terminal"
FT /evidence="ECO:0000259|SMART:SM00485"
FT DOMAIN 109..187
FT /note="XPG-I"
FT /evidence="ECO:0000259|SMART:SM00484"
FT REGION 400..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 473..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 516..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 595..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 668..699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..552
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..637
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 768 AA; 84627 MW; 54CE056872F7D313 CRC64;
MGIPGLKDEL GPGERISLAR YSIGHLQRTR KPLRLAVDIS IWLFQVQAAQ GGTNPALRTL
FFRLTRLISL PIQPIFVFDG PHRPDYKRGR LVSKNAAAAQ IELSRKLIEL FSYPCHMAPG
EAEAECAKLQ QAGVVDAVMS NDVDALMFGS KVTLLNYSKG SAKQSGAATH VDLYNTEAED
GDSKVTLDTK GMVLVALLSG GDYSPAGVAL CGPKLAVEIA RAGFGEDLFK ITQDLLSGRS
TKKAEEALCE WRERLQYELQ SNESGYFKTK HKAVKIPADF PNLAALRSCV DPVTSSLKDM
DTLRRLDIWG RRVDVDRLRA FVGRYLGWKN AIGAKNFIRK LAPSLLSYNL FYSSLGTSKD
KLRLKISGYK SADSFDALPV LKLEYVPLQI VNVDLDQETT TASPQEEEVM NIDSSDNDDT
PKESHAMVRK STLAEYDPSA SQKAWLFEAL VRRGIPDTVD DWFAEYKKKE AAKKRPVKKS
ETRKKKPKVV DPGMKAGSIL RYGTITKGPV IQRNATPSLA KESPPSSNHN LSYSDRAGTQ
TPPISSEKST DLPVSPEFID LTFSDPLDDP VGLDHAQDKK DLALSHVHIS EEMPLASTQP
GIARAASRKQ KIPKCKERIP APSERPKEPK LPKEKKAIMK SPSPLPLNST AQEFPSLNQL
SIELENIYNT NPPSDTRARH QKADRHALYR GNGPPASESN MDVFKSKMIS REHCPPALHV
EIDNGFWTKV QGASKDCPCL LTSEKNPGLN CISGRPICLG CVSVIDLT
//
