ID   F2PZS5_TRIEC            Unreviewed;       479 AA.
AC   F2PZS5;
DT   31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   31-MAY-2011, sequence version 1.
DT   27-MAR-2024, entry version 59.
DE   RecName: Full=Forkhead box protein O {ECO:0000256|ARBA:ARBA00039893};
GN   ORFNames=TEQG_06377 {ECO:0000313|EMBL:EGE07393.1};
OS   Trichophyton equinum (strain ATCC MYA-4606 / CBS 127.97) (Horse ringworm
OS   fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX   NCBI_TaxID=559882 {ECO:0000313|Proteomes:UP000009169};
RN   [1] {ECO:0000313|Proteomes:UP000009169}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4606 / CBS 127.97 {ECO:0000313|Proteomes:UP000009169};
RX   PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA   Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA   Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA   Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA   Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA   Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT   "Comparative genome analysis of Trichophyton rubrum and related
RT   dermatophytes reveals candidate genes involved in infection.";
RL   MBio 3:E259-E259(2012).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-
CC       ProRule:PRU00089}.
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DR   EMBL; DS995759; EGE07393.1; -; Genomic_DNA.
DR   AlphaFoldDB; F2PZS5; -.
DR   VEuPathDB; FungiDB:TEQG_06377; -.
DR   eggNOG; KOG2294; Eukaryota.
DR   HOGENOM; CLU_044727_0_0_1; -.
DR   Proteomes; UP000009169; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:UniProt.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR45767; FORKHEAD BOX PROTEIN O; 1.
DR   PANTHER; PTHR45767:SF2; FORKHEAD BOX PROTEIN O; 1.
DR   Pfam; PF00250; Forkhead; 1.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00089}; Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT   DOMAIN          246..343
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000259|PROSITE:PS50039"
FT   DNA_BIND        246..343
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT   REGION          181..209
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          333..400
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        385..400
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   479 AA;  52933 MW;  26556C83908DBB1E CRC64;
     MDDNTGILCP SICTQMHHSN SPPFTTPQGS EISQSQCALS SAATSLHQHR RVISHPSILQ
     QMLDPSLFGD ALQQQRQFSS MTHSHGNWGS AMEPTTFCST DAMAYDIVEN KGNVLSWEGE
     TPGPTELELD LFAATYPLFD EFRQLECLGY QTSRQPNTST TLQRNCSQIF DNHYPNSVST
     CSRPSFDSST SRPESAIYPP LSPENSVGSS SPVDFHVLYG SDSLVRSVPE AGNLASEDET
     DDDSVSSEEP YARLIWRALM SAPGHKMVLK EIYEWFEKNT SKAKNSDSKG WQNSIRHNLS
     MNAVSKEVLS PGAQTRKSGN AWVLTERAIR HGVQSTTRYR KPGVHKKSQK SDHPAPQRQK
     SGARGGRAAK KAAKYRRAIQ ESQRLDRNSH NAPPSDIPFN QHDILAQTAS CVEYGPAEPV
     NNYVLSDYGL ENLLGCNELI PRSPLFYPDL DLDENQQPSG ATTILGGQPI GRDFNSLLQ
//