ID F2Q0D0_TRIEC Unreviewed; 557 AA.
AC F2Q0D0;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=Vacuolar protein 8 {ECO:0000256|ARBA:ARBA00026209, ECO:0000256|RuleBase:RU369097};
GN ORFNames=TEQG_06469 {ECO:0000313|EMBL:EGE07555.1};
OS Trichophyton equinum (strain ATCC MYA-4606 / CBS 127.97) (Horse ringworm
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=559882 {ECO:0000313|Proteomes:UP000009169};
RN [1] {ECO:0000313|Proteomes:UP000009169}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4606 / CBS 127.97 {ECO:0000313|Proteomes:UP000009169};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- FUNCTION: Functions in both vacuole inheritance and protein targeting
CC from the cytoplasm to vacuole. {ECO:0000256|ARBA:ARBA00024821,
CC ECO:0000256|RuleBase:RU369097}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004635}; Lipid-
CC anchor {ECO:0000256|ARBA:ARBA00004635}. Vacuole membrane
CC {ECO:0000256|ARBA:ARBA00004592, ECO:0000256|RuleBase:RU369097}; Lipid-
CC anchor {ECO:0000256|ARBA:ARBA00004592, ECO:0000256|RuleBase:RU369097}.
CC -!- SIMILARITY: Belongs to the beta-catenin family.
CC {ECO:0000256|ARBA:ARBA00005462, ECO:0000256|RuleBase:RU369097}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS995762; EGE07555.1; -; Genomic_DNA.
DR AlphaFoldDB; F2Q0D0; -.
DR VEuPathDB; FungiDB:TEQG_06469; -.
DR eggNOG; KOG4224; Eukaryota.
DR HOGENOM; CLU_021483_0_0_1; -.
DR Proteomes; UP000009169; Unassembled WGS sequence.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043495; F:protein-membrane adaptor activity; IEA:InterPro.
DR GO; GO:0071562; P:nucleus-vacuole junction assembly; IEA:InterPro.
DR GO; GO:0000011; P:vacuole inheritance; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 3.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR045156; Vac8.
DR PANTHER; PTHR47249; VACUOLAR PROTEIN 8; 1.
DR PANTHER; PTHR47249:SF1; VACUOLAR PROTEIN 8; 1.
DR Pfam; PF00514; Arm; 8.
DR SMART; SM00185; ARM; 9.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 7.
PE 3: Inferred from homology;
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|RuleBase:RU369097};
KW Vacuole {ECO:0000256|ARBA:ARBA00022554, ECO:0000256|RuleBase:RU369097}.
FT REPEAT 87..129
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 128..170
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 169..211
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 210..252
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 253..295
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 294..336
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 335..378
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
SQ SEQUENCE 557 AA; 60627 MW; 42A2B6324D72DB74 CRC64;
MGNACLSCLT GRSRDSLYEP IIADSEREAV ADLLQYLENR NETDFFTGEP LRALSTLVYS
DNVDLQRSAS LTFAEITERD VREVDRDTLE PILLLLESPD IEVQRAASAA LGNLAVNTEN
KVSIVMLGGL APLIRQMMST NVEVQCNAVG CITNLATHEE NKAKIAGSGA LGPLTRLARS
KDMRVQRNAT GALLNMTHSD ENRQQLVLAG AIPILVQLLT SPDVDVQYYC TTALSNIAVD
ALNRKKLAQT ESRLVQSLVQ LMDSSTPKVQ CQAALALRNL ASDDKYQLEI VRARGLPPLL
RLLQSSYLPL ILSAVACIRN ISIHPNNESP IIDAGFLKPL VDLLGSIDNE EIQCHAISTL
RNLAASSDRN KELVLEAGAV QKCKELVLQV PLTVQSEMTA AIAVLALSDD LKGRLLKLGV
FEVLIPLTAS ESIEVQGNSA AALGNLSSKV GDYSIFVRDW TEPNGGLHGY LNRFLASGDP
TFQHIAIWTL LQLIESEDKR LLGFITRSED IIQLVRAIAN KKLESDDEGE DGEEGTAEVI
ALAQRSLELL GFDSKHS
//
