ID F2Q3Z0_TRIEC Unreviewed; 545 AA.
AC F2Q3Z0;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=ethanolamine-phosphate cytidylyltransferase {ECO:0000256|ARBA:ARBA00024221};
DE EC=2.7.7.14 {ECO:0000256|ARBA:ARBA00024221};
DE AltName: Full=CTP:phosphoethanolamine cytidylyltransferase {ECO:0000256|ARBA:ARBA00031473};
GN ORFNames=TEQG_07859 {ECO:0000313|EMBL:EGE08858.1};
OS Trichophyton equinum (strain ATCC MYA-4606 / CBS 127.97) (Horse ringworm
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=559882 {ECO:0000313|Proteomes:UP000009169};
RN [1] {ECO:0000313|Proteomes:UP000009169}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4606 / CBS 127.97 {ECO:0000313|Proteomes:UP000009169};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC -!- PATHWAY: Phospholipid metabolism; phosphatidylethanolamine
CC biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.
CC {ECO:0000256|ARBA:ARBA00024191}.
CC -!- SIMILARITY: Belongs to the cytidylyltransferase family.
CC {ECO:0000256|ARBA:ARBA00010101}.
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DR EMBL; DS995788; EGE08858.1; -; Genomic_DNA.
DR AlphaFoldDB; F2Q3Z0; -.
DR VEuPathDB; FungiDB:TEQG_07859; -.
DR eggNOG; KOG2803; Eukaryota.
DR HOGENOM; CLU_031246_0_0_1; -.
DR UniPathway; UPA00558; UER00742.
DR Proteomes; UP000009169; Unassembled WGS sequence.
DR GO; GO:0004306; F:ethanolamine-phosphate cytidylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006646; P:phosphatidylethanolamine biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd02174; CCT; 1.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR InterPro; IPR041723; CCT.
DR InterPro; IPR004821; Cyt_trans-like.
DR InterPro; IPR044608; Ect1/PCYT2.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR NCBIfam; TIGR00125; cyt_tran_rel; 1.
DR PANTHER; PTHR45780; ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE; 1.
DR PANTHER; PTHR45780:SF2; ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE; 1.
DR Pfam; PF01467; CTP_transf_like; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 2.
PE 3: Inferred from homology;
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 126..249
FT /note="Cytidyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF01467"
FT REGION 27..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 545 AA; 60975 MW; 4B853EE0C4F7930F CRC64;
MTYRPDKGRC LVIHRVEVGK VELAPKRARR RNETRQAQER TEEIRWRAPP GGSTELGHGV
VDGWITRDHL LFSATAVCWC AVCAVVQLCS CSVEMAAFER GALPRQGQWP ADPQEDVEIS
KDRIWVDGCF DFSHHGHAGA MLQARRLGKE LLVGVHSDEE ISDNKGPTVM TLAERIAAVD
ACRWSTKSIP YAPYVTSLDW ISHYGCQYVV HGDDITSDSD GNDCYRFVKE AGRFLVVKRT
PGISTTDLVG RMLLCTKTHF IKSLLAYITG KEGSGTPEEM EEAGKSHFQR IRDYATDETG
LRPGPEVWHW NGPSTLSSTP ATGGAHEQLQ QLVEGVKPKP GQKIVYVDGG FDLFSSGHIE
FLRCVHSAEE KEGEARGWFH PDQVAQRVKE HGEDYGPAYI VAGVHDDEVI NRWKGLNYPI
MNIFERGLCV LQCRYINTVV FAAPFTPTEA YLSALPFGMA DVVYHGPTTF IPLTFDPYEE
PRKLGIFKEI GNHQFQNVNA GEIVQRIMTA RAAFEERQRI KMLKSINEAE VKKQEEVAKL
SGQGN
//
