ID F2Q460_TRIEC Unreviewed; 878 AA.
AC F2Q460;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Choline kinase {ECO:0000313|EMBL:EGE08928.1};
GN ORFNames=TEQG_07883 {ECO:0000313|EMBL:EGE08928.1};
OS Trichophyton equinum (strain ATCC MYA-4606 / CBS 127.97) (Horse ringworm
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=559882 {ECO:0000313|Proteomes:UP000009169};
RN [1] {ECO:0000313|Proteomes:UP000009169}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4606 / CBS 127.97 {ECO:0000313|Proteomes:UP000009169};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC -!- PATHWAY: Phospholipid metabolism. {ECO:0000256|ARBA:ARBA00025707}.
CC -!- SIMILARITY: Belongs to the choline/ethanolamine kinase family.
CC {ECO:0000256|ARBA:ARBA00038211}.
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DR EMBL; DS995790; EGE08928.1; -; Genomic_DNA.
DR AlphaFoldDB; F2Q460; -.
DR VEuPathDB; FungiDB:TEQG_07883; -.
DR eggNOG; KOG2686; Eukaryota.
DR HOGENOM; CLU_012712_4_0_1; -.
DR Proteomes; UP000009169; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05157; ETNK_euk; 1.
DR Gene3D; 3.90.1200.10; -; 1.
DR InterPro; IPR007521; Choline_kin_N.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR PANTHER; PTHR22603; CHOLINE/ETHANOALAMINE KINASE; 1.
DR PANTHER; PTHR22603:SF93; RE24176P; 1.
DR Pfam; PF04428; Choline_kin_N; 1.
DR Pfam; PF01633; Choline_kinase; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:EGE08928.1};
KW Transferase {ECO:0000313|EMBL:EGE08928.1}.
FT DOMAIN 279..357
FT /note="Choline kinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04428"
FT REGION 1..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 179..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 245..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 306..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 378..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 674..697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 769..807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..60
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..134
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..395
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 781..795
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 878 AA; 97529 MW; EF19BA9F8C442C18 CRC64;
MDSSTRPSTQ KNLKPISTSV ATSNAPASAP VGQSVEEQQQ QQQPYTTTPD TTGTRKTFRS
GKKGVSTRPG LPKSSSASLK SVSSQISHLS LDRSNSDLST SSNANTHNNI TGLPTTSAPS
DEDRLSSSIS SFPALPPPTS EPQSFLFRSS TADDVSIQAQ YHALLGQVHQ WLHQEKSKLG
LPSTSTSTST AKSPRLIPRS TSAPLKGDLL GDTSTSADAQ IPESTLALEK LEKILSQYST
DALSGPAGAP WRRRRGGSWG QGKRGYGLKG LRRGSASDSD YTDNEMSVPS ADVVLDNSKT
LLYSGGEADS DIATQPEGSK PGSGKDKEYW LHFKSEIVRL THTLGFKGWR RVPLDAGGEV
EVVRLSGALT NAVYQVSPPK DMSKYSQSTS SQGLPRKPPP KLLLRIYGPQ VEHLIDREHE
LQVLRRLGKR NIGPRVLGTF KNGRFEQYLH ARTLTTRDLR IPETSIQIAK RMRELHEGID
LLPKERDGGP GLWKNWDKWV NRCEKVTTWL DSEILADHNE GKSAKEPWRK RGFVCGVPWE
TFRGMVDRYR QWLAASFGGM EEITRRLIFA HNDTQYGNLL RLEPSGESPL LLPANEHKQL
IVIDFEYAAA NMRGAEFANH FTEWCYNYHD EDRPWRCHTT WYPTLEEQKR FIRAYLTHRP
RLISETNNNI YPSGQNFSTS SVSSTMTTPG LRPTYTSSPR VAPLSLDTYT PSVPFSISKD
DQIDEELEVE VQKLLHEARV WRIANSAMWV AWGIVQAKVP GLEAAVAGTS TPVAHTSTTD
PASDKNDKEA ALNSDESTDD ASTTPTQETV DVQQMLAATD QALQEVEVDE AADEFDYLAY
AQDRALFFWA DILAIGLIKE EELPMEMLEH IKRRIVEY
//
