ID F2R8H3_STRVP Unreviewed; 802 AA.
AC F2R8H3;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Assimilatory nitrate reductase large subunit {ECO:0000313|EMBL:CCA53891.1};
DE EC=1.7.99.4 {ECO:0000313|EMBL:CCA53891.1};
GN OrderedLocusNames=SVEN_0604 {ECO:0000313|EMBL:CCA53891.1};
OS Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM
OS 4526 / NBRC 13096 / PD 04745).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=953739 {ECO:0000313|EMBL:CCA53891.1, ECO:0000313|Proteomes:UP000006854};
RN [1] {ECO:0000313|EMBL:CCA53891.1, ECO:0000313|Proteomes:UP000006854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10712 {ECO:0000313|EMBL:CCA53891.1};
RX PubMed=21463507; DOI=10.1186/1471-2164-12-175;
RA Pullan S.T., Bibb M.J., Merrick M.;
RT "Genome-wide analysis of the role of GlnR in Streptomyces venezuelae
RT provides new insights into global nitrogen regulation in actinomycetes.";
RL BMC Genomics 12:175-175(2011).
CC -!- COFACTOR:
CC Name=Mo-bis(molybdopterin guanine dinucleotide);
CC Xref=ChEBI:CHEBI:60539; Evidence={ECO:0000256|ARBA:ARBA00001942};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- PATHWAY: Nitrogen metabolism. {ECO:0000256|ARBA:ARBA00004909}.
CC -!- SIMILARITY: Belongs to the prokaryotic molybdopterin-containing
CC oxidoreductase family. NasA/NapA/NarB subfamily.
CC {ECO:0000256|ARBA:ARBA00008747}.
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DR EMBL; FR845719; CCA53891.1; -; Genomic_DNA.
DR AlphaFoldDB; F2R8H3; -.
DR STRING; 953739.SVEN_0604; -.
DR KEGG; sve:SVEN_0604; -.
DR PATRIC; fig|953739.5.peg.788; -.
DR eggNOG; COG0243; Bacteria.
DR HOGENOM; CLU_000422_13_4_11; -.
DR Proteomes; UP000006854; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
DR GO; GO:0008940; F:nitrate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0042128; P:nitrate assimilation; IEA:UniProtKB-KW.
DR CDD; cd02791; MopB_CT_Nitrate-R-NapA-like; 1.
DR CDD; cd02754; MopB_Nitrate-R-NapA-like; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.40.50.740; -; 1.
DR Gene3D; 3.40.228.10; Dimethylsulfoxide Reductase, domain 2; 1.
DR InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR InterPro; IPR041957; CT_Nitrate-R-NapA-like.
DR InterPro; IPR006657; MoPterin_dinucl-bd_dom.
DR InterPro; IPR006656; Mopterin_OxRdtase.
DR InterPro; IPR006963; Mopterin_OxRdtase_4Fe-4S_dom.
DR InterPro; IPR006655; Mopterin_OxRdtase_prok_CS.
DR PANTHER; PTHR43105:SF9; NITRATE REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15190)-RELATED; 1.
DR PANTHER; PTHR43105; RESPIRATORY NITRATE REDUCTASE; 1.
DR Pfam; PF00384; Molybdopterin; 1.
DR Pfam; PF01568; Molydop_binding; 1.
DR SUPFAM; SSF50692; ADC-like; 1.
DR SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
DR PROSITE; PS51669; 4FE4S_MOW_BIS_MGD; 1.
DR PROSITE; PS00490; MOLYBDOPTERIN_PROK_2; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Molybdenum {ECO:0000256|ARBA:ARBA00022505};
KW Nitrate assimilation {ECO:0000256|ARBA:ARBA00023063};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:CCA53891.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006854}.
FT DOMAIN 47..103
FT /note="4Fe-4S Mo/W bis-MGD-type"
FT /evidence="ECO:0000259|PROSITE:PS51669"
SQ SEQUENCE 802 AA; 87533 MW; 3A742378B306F272 CRC64;
MRRNPLVLSD ERIADPWGRR TPYGRGGRWP ERTDSCLAEG VAEEDVDAWV RAASLLHSDG
DAMDIAVRDG RIVGVRGRAG DRVNRGRLEP KDLYAWQANG SADRLTRPLI REGTRLVETD
WPTAMGRVVA RSRELIDSQG PKSVAFYTSG QLFLEEYYTL AVLARAGIGT PHLDGNTRLC
TATAAEALKE SFGSDGQPGS YEDIDHADAI ALFGHNIAET QVVQWMRILD RLEGDRPPRL
LCVDPRLTPV ARRADVHLAP RLGTNVALLN ALLHEVVRRG WTDPGYIARC TVGFDALCAQ
VEPCTPRWAA GICDVPAAAI EEAAELVGTA DRLLSTVLQG FYQANQATAA AVQVDNLHLI
RGMLGRPGAG VLQMNGQPTA ENTRECGADG DLPGFRNWQN EDHVADLARV WNVDPSAIPH
DAPPTHAMEI FRLAEQGAVR MLWISATNPA VSLPDLARIR AVLSREGLFT VVQDLFLTET
AQFADVVLPA ATWGEKTGTF TNADRTVHLS EKAVEPPGEA RPDLDIFLDY AARMGFEDKD
GGRLVHWSGP EEAFEAWKRC SAGRPCDYTG LTYAKLRGPS GIQWPCTEDA PDGTDRLYGD
GVSWAHPDLC ETYGKDLVTG EPLGEEWYRS TNPDGKALIR AAPYVQPREW PDEEHPFQLT
TGRTLYHFHT RTKTGRVPQL ADAAPDVWVQ IAASDASRLG LAEGDLVEVT TRTGALRGRL
RIGSMRPGVL FLPFHYGYWD TPGGRSPAPG APGRAVNEVI PTAWDPVSKQ PQFKTAAAAL
TLVAPAPRKP QEGGRDTARP TG
//
