ID F2RB14_STRVP Unreviewed; 365 AA.
AC F2RB14;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=HTH gntR-type domain-containing protein {ECO:0000259|PROSITE:PS50949};
GN OrderedLocusNames=SVEN_5947 {ECO:0000313|EMBL:CCA59233.1};
OS Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM
OS 4526 / NBRC 13096 / PD 04745).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=953739 {ECO:0000313|EMBL:CCA59233.1, ECO:0000313|Proteomes:UP000006854};
RN [1] {ECO:0000313|EMBL:CCA59233.1, ECO:0000313|Proteomes:UP000006854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10712 {ECO:0000313|EMBL:CCA59233.1};
RX PubMed=21463507; DOI=10.1186/1471-2164-12-175;
RA Pullan S.T., Bibb M.J., Merrick M.;
RT "Genome-wide analysis of the role of GlnR in Streptomyces venezuelae
RT provides new insights into global nitrogen regulation in actinomycetes.";
RL BMC Genomics 12:175-175(2011).
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DR EMBL; FR845719; CCA59233.1; -; Genomic_DNA.
DR AlphaFoldDB; F2RB14; -.
DR STRING; 953739.SVEN_5947; -.
DR KEGG; sve:SVEN_5947; -.
DR PATRIC; fig|953739.5.peg.1157; -.
DR eggNOG; COG1802; Bacteria.
DR HOGENOM; CLU_017584_5_5_11; -.
DR Proteomes; UP000006854; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR CDD; cd07377; WHTH_GntR; 1.
DR Gene3D; 1.20.120.530; GntR ligand-binding domain-like; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011711; GntR_C.
DR InterPro; IPR008920; TF_FadR/GntR_C.
DR InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR43537; TRANSCRIPTIONAL REGULATOR, GNTR FAMILY; 1.
DR PANTHER; PTHR43537:SF46; TRANSCRIPTIONAL REGULATORY PROTEIN; 1.
DR Pfam; PF07729; FCD; 1.
DR Pfam; PF00392; GntR; 1.
DR SMART; SM00895; FCD; 1.
DR SMART; SM00345; HTH_GNTR; 1.
DR SUPFAM; SSF48008; GntR ligand-binding domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50949; HTH_GNTR; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000006854};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 163..230
FT /note="HTH gntR-type"
FT /evidence="ECO:0000259|PROSITE:PS50949"
FT REGION 1..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..36
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..130
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 365 AA; 38542 MW; A637A6B64393899D CRC64;
MSARSPMVHR GPAPREPGPA RGRRRTRVEQ GAARERGVEG HPPPSGDAPG TPGGPAHAVR
VPEQATARGM EPPRGPGAGA EAAGGQRADS AGDQRTDPAR DQRTDPARDQ RTDQAGGHEA
GGHEAGGHEA GGRRPGPVTR VPDALEEHAR CEAPPAAARI VRHSVRIQIL DALRTALVGG
ELVPGEVYSA PALGERFGVS ATPVREAMQR LAVEGAVEVV PNRGFRVVER TPRELAELAE
VRALIEVPVM LRLARTVPAA RWSELRPLAE ATSAAAARGD RAHYAEADRA FHRAVLSLAG
NEQLLAVADD LHRRSQWPLI SAPAVRHGVL VADAAEHSAL LDALIVQDLP VVESLVREHF
TGSNA
//
