ID   F2RDC7_STRVP            Unreviewed;      1243 AA.
AC   F2RDC7;
DT   31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   31-MAY-2011, sequence version 1.
DT   27-MAR-2024, entry version 68.
DE   RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN   OrderedLocusNames=SVEN_6133 {ECO:0000313|EMBL:CCA59419.1};
OS   Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM
OS   4526 / NBRC 13096 / PD 04745).
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=953739 {ECO:0000313|EMBL:CCA59419.1, ECO:0000313|Proteomes:UP000006854};
RN   [1] {ECO:0000313|EMBL:CCA59419.1, ECO:0000313|Proteomes:UP000006854}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 /
RC   PD 04745 {ECO:0000313|Proteomes:UP000006854};
RX   PubMed=21463507; DOI=10.1186/1471-2164-12-175;
RA   Pullan S.T., Bibb M.J., Merrick M.;
RT   "Genome-wide analysis of the role of GlnR in Streptomyces venezuelae
RT   provides new insights into global nitrogen regulation in actinomycetes.";
RL   BMC Genomics 12:175-175(2011).
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DR   EMBL; FR845719; CCA59419.1; -; Genomic_DNA.
DR   RefSeq; WP_015037314.1; NZ_JABVZO010000163.1.
DR   AlphaFoldDB; F2RDC7; -.
DR   STRING; 953739.SVEN_6133; -.
DR   GeneID; 69868165; -.
DR   KEGG; sve:SVEN_6133; -.
DR   PATRIC; fig|953739.5.peg.1343; -.
DR   eggNOG; COG2319; Bacteria.
DR   HOGENOM; CLU_266564_0_0_11; -.
DR   OrthoDB; 4066549at2; -.
DR   Proteomes; UP000006854; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 4.
DR   InterPro; IPR011044; Quino_amine_DH_bsu.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR19879:SF1; CANNONBALL-RELATED; 1.
DR   PANTHER; PTHR19879; TRANSCRIPTION INITIATION FACTOR TFIID; 1.
DR   Pfam; PF13676; TIR_2; 1.
DR   SMART; SM00255; TIR; 1.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   SUPFAM; SSF50969; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   PROSITE; PS50104; TIR; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006854};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT   TRANSMEM        83..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        165..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        489..508
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          276..399
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
FT   REPEAT          1059..1093
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          1145..1176
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REGION          134..154
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        134..152
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1243 AA;  132841 MW;  C770274952918345 CRC64;
     MTVRRRLWWL VSCLLAWALC VPLVGPLFAL AGLAVPAAVF VPFEPLRERR LLRAHRAHRA
     RYGAVGLRRP SVRWRRLVDP ERALLVVVTG VLAGGVFWLH HPLTRQPVYW LPPAALALVL
     LRWTGALTWA PPAPPRAAAP AAPPPPAPAP PSAAAGASSR PELFIAWYGV LGALVYGVTA
     WFLQYLTVPL VRRTRSFIPE LRTLEDFYRS LGGRIADTPF GVAYDRPYWP VLAAGAGLIA
     GGAAAAARET VARTALAGRV FEELSEAQGQ GPPRETTGKV FVSYSRRDAA FARRLHEELA
     ASLREVWVDW LDIEPSAKWR ESIDEAIRGS DALIVLLSRD SLRSKYCWLE CERALALGKR
     VLPVVIDPSL EQGAGAALRE NGWEPLADYQ FLRMTRPEQF TPGVGRIHSF VKSRHRWTAF
     HTRIGLRAYE WHSGGRSGAL LLRGHELAVA EAWRHMAPDD EDGRVALTDE QVAFLRASRS
     AARRRAGRLR VAAVSVGVAL AALAALVVTG ESATVAQRRE AGSRRLAAAA NERAAGDVRQ
     AALLSAAAFT QADTAEARES LVRQLGRFDK VRGVVPAGGA PVSDVSLSVD ESVLVIWRED
     GTAQVWDTVA MRSRGIVSGT RLAGGDMSAD GRLLGVRRGS VVVLVDTRTA KEVGQADLGS
     LGLTGVFAWA DLSRDGKTLM VKPAGTPGTP DRIGLWDIDS GTLVDQVPGY MLAAGAYGRA
     TVISARDGEP AAMGHLTDPG KAPTPLPAGR LVGVTESGAP VMIDAGTIRV LTPAGHTAWT
     VGKEMRFEAI THDGRYLAVG RTADRGRYEV WDLRARKRLS TVAAPAVVGG YIPRVSLSDD
     GRWFTVATSS VSTFQRTAGH TVYSARSGRR EADLPGHAIA LGARGRLMAG AGSNGTVTLW
     DRGPAGRLLT RLDAAGAKPY GFGIAARGDT LAVLDAAGRV RLLRRSDGRL LRTVRPAADA
     FRVALSPDGA LLAVAEARGA GWQRNAQVEV FETANGRRVT VLAGQGIPSP RIVPAALVFS
     PDGSRLYLGE EHGRSVYTWH TDSWRRGPRF GPDMEVGVVE SVAVSPDGAM IAVGGGIQRV
     QVWDTATGEP LGDRLGRSVA VAFTPDGLLV LGGVGAGNPA LVLYDPRARR IVRVAPDSGE
     RTVGVAVAPD GRTLASVTGD RRLQLWDTGL ERSITVQGAT IESGDIGFTG AGDRLYALRD
     GGLSGLVVGP RRWLEALCAI TGGPMTADQW QEAAPGERFR QVC
//