ID F2RDQ8_STRVP Unreviewed; 4991 AA.
AC F2RDQ8;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 71.
DE SubName: Full=CDA peptide synthetase I {ECO:0000313|EMBL:CCA59550.1};
GN OrderedLocusNames=SVEN_6264 {ECO:0000313|EMBL:CCA59550.1};
OS Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM
OS 4526 / NBRC 13096 / PD 04745).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=953739 {ECO:0000313|EMBL:CCA59550.1, ECO:0000313|Proteomes:UP000006854};
RN [1] {ECO:0000313|EMBL:CCA59550.1, ECO:0000313|Proteomes:UP000006854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 /
RC PD 04745 {ECO:0000313|Proteomes:UP000006854};
RX PubMed=21463507; DOI=10.1186/1471-2164-12-175;
RA Pullan S.T., Bibb M.J., Merrick M.;
RT "Genome-wide analysis of the role of GlnR in Streptomyces venezuelae
RT provides new insights into global nitrogen regulation in actinomycetes.";
RL BMC Genomics 12:175-175(2011).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; FR845719; CCA59550.1; -; Genomic_DNA.
DR STRING; 953739.SVEN_6264; -.
DR KEGG; sve:SVEN_6264; -.
DR PATRIC; fig|953739.5.peg.1471; -.
DR eggNOG; COG1020; Bacteria.
DR HOGENOM; CLU_000022_0_15_11; -.
DR OMA; CTGVQKS; -.
DR Proteomes; UP000006854; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 2.
DR CDD; cd19540; LCL_NRPS-like; 2.
DR Gene3D; 3.30.300.30; -; 4.
DR Gene3D; 3.40.50.980; -; 6.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 5.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 5.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 4.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 4.
DR Pfam; PF13193; AMP-binding_C; 4.
DR Pfam; PF00668; Condensation; 5.
DR Pfam; PF00550; PP-binding; 4.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 4.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 4.
DR SUPFAM; SSF47336; ACP-like; 4.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 10.
DR PROSITE; PS00455; AMP_BINDING; 4.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 4.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000006854}.
FT DOMAIN 978..1051
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2493..2568
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3562..3637
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4628..4702
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 68..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 960..980
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1040..1059
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2472..2494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2477..2494
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4991 AA; 533957 MW; 6FE43506BB05F54B CRC64;
MMTSTPGAGP ALTAGQVEIW LDARDAGPAS AYNSAGYLDI RGPLDTGRFR TALRRLVDEA
QCLRARFTDH DGEPRQSVEP LPEPPLTEVD LRHTDDPAAA AQDWMRRDLA VPLRIEDFPL
MRTALLTVAP DRTLFYLCVH HLLCDGFSQT VLWHRLAELY AADPAAPAPA GALPPLGELA
AAETAYQASR AARRDAEFWQ RRFPEPPELA TLSRRAPTAG LPDGSLRRSV VLPEETARAL
RESAGRADVT WPTVAMAAVA LYTQRTSGTD EVLLTLPVTA RMTAQQRAVP GMMANYLPLR
VPVRPTLTKA DLLRATSREL AQVLRHQRHR VSAIRRGMGL RSDDRRPFGP FVNLLPQQTG
LDLGPCTAEV HNLSTGLVDD VMVTLVETPG GGIEIHLNGN PDRYTEAETE RHLDRLAAFL
GRFATAAGEE RLGGLDAPGD PAGATADGHA DWLRTALGPE RPAEFDSLVE RVREQAARRP
DAIAVEDDDA RVTYASLVGR ASALSRALPG GGLVGVLVTP GVGYVTSVLA VIGAGAAYVP
LDPHAPVART AALIADHGID RLIADAPHHA LAEQAAAAAG RPVRIVTPDD AEDPLAALAP
LAGTPQDLAY VIFTSGSTGQ PKGAMVHRAG MVNHLLAKVD DLALTERDTL VQNAPVTFDI
SVWQMLAPLV VGGRVRVVGR DTAADPDLLF ALTAEDGVTV LEVVPSLLRA ALDAWDLTGT
GVDLPGLRHL MVTGEALPAD LCHRWLARHP GTPLVNAYGP TECSDDVTHA HIRRAPAADG
PVPIGVPVRN TRLYVLGDDL RPLPDGTPGE LYVAGTGVGR GYLGDPARTA GTFVPDPYGA
AGSRMYRTGD RVRRDDDGAL VFLERRDHQV KIRGHRIELG EIETALRRHP DLADAVVTVV
DDASGGKHLV AHCVPREHTR PDTGALRGHL AATLPAYMVP QHLLVLDALP LTAHGKVDRK
ALPRPATGRA SAAQDPATPR SRGEEILCAV FTEVLGVPAG ADDNFFELGG DSITAIQAVS
HARKAGLAVT PLLIRKHGTP RAVAAATPAD GPARPAAGGH DDTGEIELAP IAHQLREDLA
SLDERSREYS QFVVLRTPAD LGPDVLASAV DALLDRHAAL RTRLTVPVEG LWSLEALPPG
AVTAADVVHH VDVSHLADDP RALADAVREQ TGLARARLSP DTGRVTQLVL LDRGPGRTGR
LLWLTHHLCV DGVSWRVLTG DLAAAVAGDS PDPVPTPYRA WTKLLGAHAR TTDRVSEFPL
WNEQFGSGAA PLGDRVLDPL RDVYGTARRL RLELDSETTA AVLAGVRGIE DGEINDLLLT
ALGMAVADWR RRNGRGDCDG TTVELEGHGR EQFTDEVDLS RTVGWFTSVY PVLLGPGPLV
DWDDLWAGGD TAGTALQDTR GRLRRLPDHG LGYGLLRHLN PQTLASLARH GVPEIGFNYL
GRFQTEAPSG DWSLVTEDAV IGTGVHPRMP LRHVLAVTPV TEDRADGPYL VADWIWAADL
FPDADAEDIA RTWFRALKAL AGHTARAAER GPRDETLPLS PLQQGLLIQA ELERHGTDSY
LLQTVLDIEG PFDTDAFRAA ADALLARHPG LRVSFPEAAP DEQRVQSVAG RVTAPWTDVD
LTGTASEAAR EAETARITEA DWERGFDLTA APLLRFTAIR LPGGRVRLLW TLHHLLADGW
SMGILARELF TLYAAGGDAS ALPPAPSYRD YFGWLAAQDT EAAKAAWRTA LAGVTEPTVL
STGEHAESTR PPESLVHELP EDLTADLTAF ARARNVTLNT VLQACWAVVL GRRTGRGDLV
FGTVSSARPP ELPGVEGMVG LFLNMLPQRV TLDPAEPFTD LVQRLYAQQT DLLEHQHIGL
GEVQRLAGAG DLFDTVFSFQ NQPRADLDEL NALVPALRLG NGTTRLAAER GLAVLVHPGP
RLTLTLQYRP AAHQRTAVEE TLRQLVEVVG TVVTRPATPV GRLTLDDTAE HRRLVREWGG
RADDTARPVI PALFQSRVAE NPRAVAIVSG ATEVTYEELD RRANRLARLL LARGAGPERT
VALALSDPVD MTAALLAVLK AGAAYLPIDP KYPADRIAYM LSDSGPATLV TTTELAGRLP
DAECAVLLLD EERTTAELAA LPDHAPEDGD RPQPLDPRHP AYVIYTSGST GRPKGVTVDH
AGFAAMVASL VEKFGVDHRA RVLKFASFSF DASVWELSLS LLAGGTLVVA DEDCRVPGKP
LVDLLQRHRV NLAGLPPVVV GALPEGSRLP EDLTLIVAGE ACPPHVVERW AGQVRMFNGY
GPTEAVLAST VSDPLRGAGH PPIGRPTGAH RVYVLDEALR PVPAGAVGEL YVGGNLARGY
QHRPDLTAKR FVADPYGPAG ARMYRTGDLA NWRPDGQLHY VGRADDQVQL RGFRVELGEI
ETELAARPEV RQAAAVVRSA DGQEDRLVAY VVPATPGGAD AAVLREALAA VLPEYMVPAA
IVSLDELPLT PQGKLDRKAL PDPEETRTRR GRAPRTPVEE ILCGIFAELL QISDVGIDDD
FFELGGHSLL ATRVVSRART ALDVEMPIRT LFEARTVAGV VARLGTGDTV RPALRRTPRE
DPAGHLPLSF TQTRLWFLNR LDPESAAYNV SFAVRLSGAV DVPALDAALA DVVGRHESLR
TVFPEVDGEP RQVVLDAADV WSGLEVTDLD AAGAASLSAA RAARGFDLTT EIPVRAHLYR
TAPGEQLLQL VVHHIAWDGW SVAPLVRDLS RAYAARHSGG APEWSVLPVQ YADFAVWQRE
LLGDETDASS AVARQLDFWR ERLAGMPEEL ELPFDRARPA VMSHRGGTVP FRLDADAHAA
LVRLARESGA SVFMVLQAAL AALLSRLGAG EDVPIGSPVA GRLDDALDEL VGCFMNTLVL
RTDVSGDPTF RQLLDRARET SLSAFAHQDV PFERLVEVLD PVRSMGRNPL FQVMLVLQNN
EQAHLELPGV RAAFEPPSVD SVKFDLNFFV VEQQHADGTA DGLDGFLEFS ADVFDESTAA
SVAARFVRLL HQVAGDPDLP VGGIEVLAAS ERERILTDWS GTTGGNPDTT VAALFEDQAA
RSPEAVAVVC DGTELSYTEL NARANRLARQ LIERGAGPER LVALGLPRTE QMVVALLAVL
KSGAAYLPLD LAYPADRIAL MLDDARPALL LTDGPTAATL PPTELPTLLL DDPATTAARA
DLPTTDVTDE ERPAPAGPYR PAFVIYTSGS TGRPKGVTGL HRALVNRLTW FAEEFPEQRT
AAVLAKSPVS VIDGITELLA PLLSGGSTVL VDAHTARSVP DLADAVVRHG IARLTVVPSL
LNAFIDSGEL PRMAGCAVWI CSGEQLPAAT VDRFRAALPS ARLVNFYGAS EVGAVATHGA
RDEVNLGPAT LIGRPIRNTG VYVLDAGLRP VPAGVAGELY LSGAGLARGY VDRAGLTASR
FVACPFGTDG GRMYRTGDVV RWSADGRLVF LGRADDQVKV RGFRVEPGEV EEVLLGHPSV
ARTVVVARAD GPGAGVLVGY VVPTPGVSLD TAAVRAFVAR SLPEYMVPIV VALDELPLTP
SGKVDRKALP APDLGAVVSS RTPRDPVEEV LCALYAQVLG LERVGIDDSF FDLGGHSLLA
TRLVSRARSA LSTALSIRDV FEAPTVAALA DRARTGERDR PPLAAVPRTG ALPTSSAQRR
LWFLNRLEGP ESAAYNMRFA VRLSGALDVP ALDAALADVV GRHESLRTVF PEVDGEPRQV
VLDAAEVWPG LVVRDTRDAR DARDTDAGDA VSVPAGRGFD LTTEIPLRAH LFRTADDEHL
LLLVVHHIAA DGWSVAPLAR DVSRAYAARC GGAAPEWSVL PVQYADFAVW QRELLGDEAD
PSSAVARQLD FWRQRLAGMP EELALPFDRP RPVVMSHRGG TVPFTLDAGA HAALVRLARE
SGGSVFMVLQ AALAALLSRL GAGEDVPIGS PVAGRLDEAL DELVGCFMNT LVLRTDVSGD
PTFRQLLDRA RETALGAFEH QDVPFERLVE VLDPVRSMGR NPLFQVMLSL QNNEHADLEL
PGLTVTQEPV GADTAKFDLS LTLMERQDAQ GAPGGLEGFL EFSADVFEES TAASVAARLA
RLLQQVAGDP DVPVSGIELL TADERHRILT EWNDTAQPQS PVTLPEAFQR QAARSPEAVA
VVSGGTELSY AELNARANRL ARELIERGAG PERLVALGLP RTEQMVVALL AVLKSGAAYL
PVDPAHPAER IELVLGDARP ALLVTDTATA GRLPDTGVPR LVLDDPGTVA AVAARDAADI
GDAERAAPLH PEHKAYVLYT SGSTGRPKGV AIEHRNLMNF LLSMAERFPM DAGDRLLAVT
TWSFDIAGLE VYVPLLSGAG VVVGEDGLVL DPEALTALVR RAGVTVMQAT PALWQELVTR
EPEAVRGLRV LVGGEAVPPA LAEALTAHAA EVTNLYGPTE TTIWSTAVQL VADEPVTLGR
PIRNTGVYVL DAGLRPVPAG VAGELYLSGA GVARGYVGRA GLTASRFVAC PFGTDGGRMY
RTGDVVRWSA DGRLVFLGRA DDQVKVRGFR VEPGEVEEVL LGHPSVARAV VVARADGPGS
GVLVGYVVPA PGESVDTAAV RAFVARALPE YMVPVLVVLD TLPLNPSGKV DRKALPAPDL
GAAVSSRMPR DPVEESLCAL FAQVLGLERV GVDDSFFDLG GHSLLAVRLV SRAQAAGLRL
SVADVVLHRT VAALATRAEK TGPDQENLLD PFSIVLPVRP GGDAPPVFLV HSGLGFSLPY
VGLARYLDRR HPLYGLQSPA VGGAAPAPDD IRAVAAEYIG HIRRISPHGP YRLLGWSYGG
VLAHEIAVQL QQAGEEVDFL ANLDGYLGST GREDTDDEQE LLLRALESLG HSRAAFADQP
LTPAGLLDVL RRENHPLAEL GERGIPRLLR LSRTHGELME RFTAGRFTGD MHLFTATREW
TADRLDDQTR RWEPHVDGHL RIHPVDCGHE YLMHPGPQAV VGRAVDAALA RLDAARDGAS
GGDEGTRGGD R
//