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Database: UniProt
Entry: F2RDQ8_STRVP
LinkDB: F2RDQ8_STRVP
Original site: F2RDQ8_STRVP 
ID   F2RDQ8_STRVP            Unreviewed;      4991 AA.
AC   F2RDQ8;
DT   31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   31-MAY-2011, sequence version 1.
DT   24-JAN-2024, entry version 71.
DE   SubName: Full=CDA peptide synthetase I {ECO:0000313|EMBL:CCA59550.1};
GN   OrderedLocusNames=SVEN_6264 {ECO:0000313|EMBL:CCA59550.1};
OS   Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM
OS   4526 / NBRC 13096 / PD 04745).
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=953739 {ECO:0000313|EMBL:CCA59550.1, ECO:0000313|Proteomes:UP000006854};
RN   [1] {ECO:0000313|EMBL:CCA59550.1, ECO:0000313|Proteomes:UP000006854}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 /
RC   PD 04745 {ECO:0000313|Proteomes:UP000006854};
RX   PubMed=21463507; DOI=10.1186/1471-2164-12-175;
RA   Pullan S.T., Bibb M.J., Merrick M.;
RT   "Genome-wide analysis of the role of GlnR in Streptomyces venezuelae
RT   provides new insights into global nitrogen regulation in actinomycetes.";
RL   BMC Genomics 12:175-175(2011).
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR   EMBL; FR845719; CCA59550.1; -; Genomic_DNA.
DR   STRING; 953739.SVEN_6264; -.
DR   KEGG; sve:SVEN_6264; -.
DR   PATRIC; fig|953739.5.peg.1471; -.
DR   eggNOG; COG1020; Bacteria.
DR   HOGENOM; CLU_000022_0_15_11; -.
DR   OMA; CTGVQKS; -.
DR   Proteomes; UP000006854; Chromosome.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR   GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR   GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR   CDD; cd05930; A_NRPS; 2.
DR   CDD; cd19540; LCL_NRPS-like; 2.
DR   Gene3D; 3.30.300.30; -; 4.
DR   Gene3D; 3.40.50.980; -; 6.
DR   Gene3D; 1.10.1200.10; ACP-like; 3.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 5.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 5.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR010060; NRPS_synth.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR001031; Thioesterase.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 4.
DR   NCBIfam; TIGR01720; NRPS-para261; 1.
DR   PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 4.
DR   Pfam; PF13193; AMP-binding_C; 4.
DR   Pfam; PF00668; Condensation; 5.
DR   Pfam; PF00550; PP-binding; 4.
DR   Pfam; PF00975; Thioesterase; 1.
DR   SMART; SM00823; PKS_PP; 4.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 4.
DR   SUPFAM; SSF47336; ACP-like; 4.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 10.
DR   PROSITE; PS00455; AMP_BINDING; 4.
DR   PROSITE; PS50075; CARRIER; 4.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 4.
PE   4: Predicted;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006854}.
FT   DOMAIN          978..1051
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          2493..2568
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          3562..3637
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          4628..4702
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   REGION          68..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          960..980
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1040..1059
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2472..2494
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2477..2494
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   4991 AA;  533957 MW;  6FE43506BB05F54B CRC64;
     MMTSTPGAGP ALTAGQVEIW LDARDAGPAS AYNSAGYLDI RGPLDTGRFR TALRRLVDEA
     QCLRARFTDH DGEPRQSVEP LPEPPLTEVD LRHTDDPAAA AQDWMRRDLA VPLRIEDFPL
     MRTALLTVAP DRTLFYLCVH HLLCDGFSQT VLWHRLAELY AADPAAPAPA GALPPLGELA
     AAETAYQASR AARRDAEFWQ RRFPEPPELA TLSRRAPTAG LPDGSLRRSV VLPEETARAL
     RESAGRADVT WPTVAMAAVA LYTQRTSGTD EVLLTLPVTA RMTAQQRAVP GMMANYLPLR
     VPVRPTLTKA DLLRATSREL AQVLRHQRHR VSAIRRGMGL RSDDRRPFGP FVNLLPQQTG
     LDLGPCTAEV HNLSTGLVDD VMVTLVETPG GGIEIHLNGN PDRYTEAETE RHLDRLAAFL
     GRFATAAGEE RLGGLDAPGD PAGATADGHA DWLRTALGPE RPAEFDSLVE RVREQAARRP
     DAIAVEDDDA RVTYASLVGR ASALSRALPG GGLVGVLVTP GVGYVTSVLA VIGAGAAYVP
     LDPHAPVART AALIADHGID RLIADAPHHA LAEQAAAAAG RPVRIVTPDD AEDPLAALAP
     LAGTPQDLAY VIFTSGSTGQ PKGAMVHRAG MVNHLLAKVD DLALTERDTL VQNAPVTFDI
     SVWQMLAPLV VGGRVRVVGR DTAADPDLLF ALTAEDGVTV LEVVPSLLRA ALDAWDLTGT
     GVDLPGLRHL MVTGEALPAD LCHRWLARHP GTPLVNAYGP TECSDDVTHA HIRRAPAADG
     PVPIGVPVRN TRLYVLGDDL RPLPDGTPGE LYVAGTGVGR GYLGDPARTA GTFVPDPYGA
     AGSRMYRTGD RVRRDDDGAL VFLERRDHQV KIRGHRIELG EIETALRRHP DLADAVVTVV
     DDASGGKHLV AHCVPREHTR PDTGALRGHL AATLPAYMVP QHLLVLDALP LTAHGKVDRK
     ALPRPATGRA SAAQDPATPR SRGEEILCAV FTEVLGVPAG ADDNFFELGG DSITAIQAVS
     HARKAGLAVT PLLIRKHGTP RAVAAATPAD GPARPAAGGH DDTGEIELAP IAHQLREDLA
     SLDERSREYS QFVVLRTPAD LGPDVLASAV DALLDRHAAL RTRLTVPVEG LWSLEALPPG
     AVTAADVVHH VDVSHLADDP RALADAVREQ TGLARARLSP DTGRVTQLVL LDRGPGRTGR
     LLWLTHHLCV DGVSWRVLTG DLAAAVAGDS PDPVPTPYRA WTKLLGAHAR TTDRVSEFPL
     WNEQFGSGAA PLGDRVLDPL RDVYGTARRL RLELDSETTA AVLAGVRGIE DGEINDLLLT
     ALGMAVADWR RRNGRGDCDG TTVELEGHGR EQFTDEVDLS RTVGWFTSVY PVLLGPGPLV
     DWDDLWAGGD TAGTALQDTR GRLRRLPDHG LGYGLLRHLN PQTLASLARH GVPEIGFNYL
     GRFQTEAPSG DWSLVTEDAV IGTGVHPRMP LRHVLAVTPV TEDRADGPYL VADWIWAADL
     FPDADAEDIA RTWFRALKAL AGHTARAAER GPRDETLPLS PLQQGLLIQA ELERHGTDSY
     LLQTVLDIEG PFDTDAFRAA ADALLARHPG LRVSFPEAAP DEQRVQSVAG RVTAPWTDVD
     LTGTASEAAR EAETARITEA DWERGFDLTA APLLRFTAIR LPGGRVRLLW TLHHLLADGW
     SMGILARELF TLYAAGGDAS ALPPAPSYRD YFGWLAAQDT EAAKAAWRTA LAGVTEPTVL
     STGEHAESTR PPESLVHELP EDLTADLTAF ARARNVTLNT VLQACWAVVL GRRTGRGDLV
     FGTVSSARPP ELPGVEGMVG LFLNMLPQRV TLDPAEPFTD LVQRLYAQQT DLLEHQHIGL
     GEVQRLAGAG DLFDTVFSFQ NQPRADLDEL NALVPALRLG NGTTRLAAER GLAVLVHPGP
     RLTLTLQYRP AAHQRTAVEE TLRQLVEVVG TVVTRPATPV GRLTLDDTAE HRRLVREWGG
     RADDTARPVI PALFQSRVAE NPRAVAIVSG ATEVTYEELD RRANRLARLL LARGAGPERT
     VALALSDPVD MTAALLAVLK AGAAYLPIDP KYPADRIAYM LSDSGPATLV TTTELAGRLP
     DAECAVLLLD EERTTAELAA LPDHAPEDGD RPQPLDPRHP AYVIYTSGST GRPKGVTVDH
     AGFAAMVASL VEKFGVDHRA RVLKFASFSF DASVWELSLS LLAGGTLVVA DEDCRVPGKP
     LVDLLQRHRV NLAGLPPVVV GALPEGSRLP EDLTLIVAGE ACPPHVVERW AGQVRMFNGY
     GPTEAVLAST VSDPLRGAGH PPIGRPTGAH RVYVLDEALR PVPAGAVGEL YVGGNLARGY
     QHRPDLTAKR FVADPYGPAG ARMYRTGDLA NWRPDGQLHY VGRADDQVQL RGFRVELGEI
     ETELAARPEV RQAAAVVRSA DGQEDRLVAY VVPATPGGAD AAVLREALAA VLPEYMVPAA
     IVSLDELPLT PQGKLDRKAL PDPEETRTRR GRAPRTPVEE ILCGIFAELL QISDVGIDDD
     FFELGGHSLL ATRVVSRART ALDVEMPIRT LFEARTVAGV VARLGTGDTV RPALRRTPRE
     DPAGHLPLSF TQTRLWFLNR LDPESAAYNV SFAVRLSGAV DVPALDAALA DVVGRHESLR
     TVFPEVDGEP RQVVLDAADV WSGLEVTDLD AAGAASLSAA RAARGFDLTT EIPVRAHLYR
     TAPGEQLLQL VVHHIAWDGW SVAPLVRDLS RAYAARHSGG APEWSVLPVQ YADFAVWQRE
     LLGDETDASS AVARQLDFWR ERLAGMPEEL ELPFDRARPA VMSHRGGTVP FRLDADAHAA
     LVRLARESGA SVFMVLQAAL AALLSRLGAG EDVPIGSPVA GRLDDALDEL VGCFMNTLVL
     RTDVSGDPTF RQLLDRARET SLSAFAHQDV PFERLVEVLD PVRSMGRNPL FQVMLVLQNN
     EQAHLELPGV RAAFEPPSVD SVKFDLNFFV VEQQHADGTA DGLDGFLEFS ADVFDESTAA
     SVAARFVRLL HQVAGDPDLP VGGIEVLAAS ERERILTDWS GTTGGNPDTT VAALFEDQAA
     RSPEAVAVVC DGTELSYTEL NARANRLARQ LIERGAGPER LVALGLPRTE QMVVALLAVL
     KSGAAYLPLD LAYPADRIAL MLDDARPALL LTDGPTAATL PPTELPTLLL DDPATTAARA
     DLPTTDVTDE ERPAPAGPYR PAFVIYTSGS TGRPKGVTGL HRALVNRLTW FAEEFPEQRT
     AAVLAKSPVS VIDGITELLA PLLSGGSTVL VDAHTARSVP DLADAVVRHG IARLTVVPSL
     LNAFIDSGEL PRMAGCAVWI CSGEQLPAAT VDRFRAALPS ARLVNFYGAS EVGAVATHGA
     RDEVNLGPAT LIGRPIRNTG VYVLDAGLRP VPAGVAGELY LSGAGLARGY VDRAGLTASR
     FVACPFGTDG GRMYRTGDVV RWSADGRLVF LGRADDQVKV RGFRVEPGEV EEVLLGHPSV
     ARTVVVARAD GPGAGVLVGY VVPTPGVSLD TAAVRAFVAR SLPEYMVPIV VALDELPLTP
     SGKVDRKALP APDLGAVVSS RTPRDPVEEV LCALYAQVLG LERVGIDDSF FDLGGHSLLA
     TRLVSRARSA LSTALSIRDV FEAPTVAALA DRARTGERDR PPLAAVPRTG ALPTSSAQRR
     LWFLNRLEGP ESAAYNMRFA VRLSGALDVP ALDAALADVV GRHESLRTVF PEVDGEPRQV
     VLDAAEVWPG LVVRDTRDAR DARDTDAGDA VSVPAGRGFD LTTEIPLRAH LFRTADDEHL
     LLLVVHHIAA DGWSVAPLAR DVSRAYAARC GGAAPEWSVL PVQYADFAVW QRELLGDEAD
     PSSAVARQLD FWRQRLAGMP EELALPFDRP RPVVMSHRGG TVPFTLDAGA HAALVRLARE
     SGGSVFMVLQ AALAALLSRL GAGEDVPIGS PVAGRLDEAL DELVGCFMNT LVLRTDVSGD
     PTFRQLLDRA RETALGAFEH QDVPFERLVE VLDPVRSMGR NPLFQVMLSL QNNEHADLEL
     PGLTVTQEPV GADTAKFDLS LTLMERQDAQ GAPGGLEGFL EFSADVFEES TAASVAARLA
     RLLQQVAGDP DVPVSGIELL TADERHRILT EWNDTAQPQS PVTLPEAFQR QAARSPEAVA
     VVSGGTELSY AELNARANRL ARELIERGAG PERLVALGLP RTEQMVVALL AVLKSGAAYL
     PVDPAHPAER IELVLGDARP ALLVTDTATA GRLPDTGVPR LVLDDPGTVA AVAARDAADI
     GDAERAAPLH PEHKAYVLYT SGSTGRPKGV AIEHRNLMNF LLSMAERFPM DAGDRLLAVT
     TWSFDIAGLE VYVPLLSGAG VVVGEDGLVL DPEALTALVR RAGVTVMQAT PALWQELVTR
     EPEAVRGLRV LVGGEAVPPA LAEALTAHAA EVTNLYGPTE TTIWSTAVQL VADEPVTLGR
     PIRNTGVYVL DAGLRPVPAG VAGELYLSGA GVARGYVGRA GLTASRFVAC PFGTDGGRMY
     RTGDVVRWSA DGRLVFLGRA DDQVKVRGFR VEPGEVEEVL LGHPSVARAV VVARADGPGS
     GVLVGYVVPA PGESVDTAAV RAFVARALPE YMVPVLVVLD TLPLNPSGKV DRKALPAPDL
     GAAVSSRMPR DPVEESLCAL FAQVLGLERV GVDDSFFDLG GHSLLAVRLV SRAQAAGLRL
     SVADVVLHRT VAALATRAEK TGPDQENLLD PFSIVLPVRP GGDAPPVFLV HSGLGFSLPY
     VGLARYLDRR HPLYGLQSPA VGGAAPAPDD IRAVAAEYIG HIRRISPHGP YRLLGWSYGG
     VLAHEIAVQL QQAGEEVDFL ANLDGYLGST GREDTDDEQE LLLRALESLG HSRAAFADQP
     LTPAGLLDVL RRENHPLAEL GERGIPRLLR LSRTHGELME RFTAGRFTGD MHLFTATREW
     TADRLDDQTR RWEPHVDGHL RIHPVDCGHE YLMHPGPQAV VGRAVDAALA RLDAARDGAS
     GGDEGTRGGD R
//
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