ID F2RIP6_STRVP Unreviewed; 525 AA.
AC F2RIP6;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=NADH-ubiquinone oxidoreductase chain M {ECO:0000313|EMBL:CCA57602.1};
DE EC=1.6.5.3 {ECO:0000313|EMBL:CCA57602.1};
GN OrderedLocusNames=SVEN_4316 {ECO:0000313|EMBL:CCA57602.1};
OS Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM
OS 4526 / NBRC 13096 / PD 04745).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=953739 {ECO:0000313|EMBL:CCA57602.1, ECO:0000313|Proteomes:UP000006854};
RN [1] {ECO:0000313|EMBL:CCA57602.1, ECO:0000313|Proteomes:UP000006854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 /
RC PD 04745 {ECO:0000313|Proteomes:UP000006854};
RX PubMed=21463507; DOI=10.1186/1471-2164-12-175;
RA Pullan S.T., Bibb M.J., Merrick M.;
RT "Genome-wide analysis of the role of GlnR in Streptomyces venezuelae
RT provides new insights into global nitrogen regulation in actinomycetes.";
RL BMC Genomics 12:175-175(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU000320}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU000320}.
CC -!- SIMILARITY: Belongs to the complex I subunit 4 family.
CC {ECO:0000256|ARBA:ARBA00009025}.
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DR EMBL; FR845719; CCA57602.1; -; Genomic_DNA.
DR AlphaFoldDB; F2RIP6; -.
DR STRING; 953739.SVEN_4316; -.
DR KEGG; sve:SVEN_4316; -.
DR PATRIC; fig|953739.5.peg.6817; -.
DR eggNOG; COG1008; Bacteria.
DR HOGENOM; CLU_007100_4_0_11; -.
DR Proteomes; UP000006854; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR010227; NADH_Q_OxRdtase_chainM/4.
DR InterPro; IPR003918; NADH_UbQ_OxRdtase.
DR InterPro; IPR001750; ND/Mrp_mem.
DR NCBIfam; TIGR01972; NDH_I_M; 1.
DR PANTHER; PTHR43507:SF1; NAD(P)H-QUINONE OXIDOREDUCTASE CHAIN 4, CHLOROPLASTIC; 1.
DR PANTHER; PTHR43507; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR PRINTS; PR01437; NUOXDRDTASE4.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000313|EMBL:CCA57602.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006854};
KW Transmembrane {ECO:0000256|RuleBase:RU000320, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Ubiquinone {ECO:0000313|EMBL:CCA57602.1}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 43..66
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 153..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 182..200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 220..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 259..279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 291..313
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 325..345
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 351..373
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 400..421
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 441..464
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 148..432
FT /note="NADH:quinone oxidoreductase/Mrp antiporter membrane
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF00361"
SQ SEQUENCE 525 AA; 54299 MW; 75F0685C1FB783A6 CRC64;
MIDISESVMQ FLLALIVAGP LVGAAAALLP APPGLKGTSP DQAVLRHGVV VTGVILLAAI
VLAVGFDHDQ PSTMQATTDI TWIKALDVRI HLGVDGISLP LLVLTALLTF LCALYSYFKM
PAGPSPKGFV ALLLVLESGT LATFAVLDLV LFFLAFEMVL IPMYFLIARW GGEGKQAAAW
KFILYTLLGS VVMLLGLLLI GVKAGTFDMV ALATDNGRGL TTSVQVIAVL AIGIGLAVKT
PMWPLHSWLP DAHTAAPTVG SVLLAGVLLK MGTYGFVRIV LPIAPDGMRT FAPSLAAFAV
AGIIYGSLAC LALARPGNKG DLKRLIAYSS VGHMGFVLLG IATMTPTGVN GALFANVAHG
LVTGLLFFLV GAVKDRYGTA DLDTLAGATG AALYGRAPRL GALLAFAAVA SLGLPGLAGF
WGEMLALFGA FDPAEGLSRP AFLTFMAIGA FGTLLTAAYL LLVVRRVCMG GPRPAGETPI
ADVQGYEFAA WTPLVALTVL AGLWPAVLLG LTDPAVQKLL AGGTQ
//
