ID   F2SC89_TRIRC            Unreviewed;       488 AA.
AC   F2SC89;
DT   31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   31-MAY-2011, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   RecName: Full=Carnosine N-methyltransferase {ECO:0000256|ARBA:ARBA00015448};
DE            EC=2.1.1.22 {ECO:0000256|ARBA:ARBA00012003};
GN   ORFNames=TERG_00597 {ECO:0000313|EMBL:EGD84315.1};
OS   Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892) (Athlete's foot
OS   fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX   NCBI_TaxID=559305 {ECO:0000313|EMBL:EGD84315.1, ECO:0000313|Proteomes:UP000008864};
RN   [1] {ECO:0000313|Proteomes:UP000008864}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4607 / CBS 118892 {ECO:0000313|Proteomes:UP000008864};
RX   PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA   Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA   Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA   Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA   Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA   Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT   "Comparative genome analysis of Trichophyton rubrum and related
RT   dermatophytes reveals candidate genes involved in infection.";
RL   MBio 3:E259-E259(2012).
CC   -!- SIMILARITY: Belongs to the carnosine N-methyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00010086}.
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DR   EMBL; GG700648; EGD84315.1; -; Genomic_DNA.
DR   RefSeq; XP_003238606.1; XM_003238558.1.
DR   AlphaFoldDB; F2SC89; -.
DR   STRING; 559305.F2SC89; -.
DR   GeneID; 10374235; -.
DR   VEuPathDB; FungiDB:TERG_00597; -.
DR   eggNOG; KOG2798; Eukaryota.
DR   HOGENOM; CLU_030612_2_0_1; -.
DR   InParanoid; F2SC89; -.
DR   OMA; LWTGGGQ; -.
DR   OrthoDB; 2721776at2759; -.
DR   Proteomes; UP000008864; Unassembled WGS sequence.
DR   GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR012901; CARME.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR12303:SF6; CARNOSINE N-METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR12303; UNCHARACTERIZED; 1.
DR   Pfam; PF07942; CARME; 1.
DR   SMART; SM01296; N2227; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008864};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
SQ   SEQUENCE   488 AA;  55606 MW;  CCD7CBDC06E7723A CRC64;
     MTRPYALISL ALSIVIGLAL VSILDDITNP TLRSNVKPSI YKLAGINALT SFLEKYIPTS
     YLRLPPLRAG LPAYYQHSSG HNATNVNREK LKGRTISTRQ WEEKSRLRDR MKRDDNKKWD
     SSHPRYRLLT AMHGFARYKD RNLAEADRWN TLYLNSPMRH RKFLESTIGY TSKLNKVKDL
     FAENDALAQA ILAHALDFYE VERAELDQFI QEAESNGIVA DKTSTSQAMK HFVRDWSTEG
     LFERDAAFPC VLEALQNYTV RSNDRPLRVL IPGSGLGRLA HDVSKLEGFE VTSNEWSSYM
     NIAYRYVEAL QLLNSETFFP FIDWWSHQAS TTDLLRPVQF PDTIPYHANS SLDRSLIHIE
     GDFNSMHHGL PAAETKYDVV ITLFFIDTAR NLMSYFETIQ DSLNEGGTWI NLGPLLYGSA
     PFLQLSLDEI VDVCEHLGFE FLDTSSKCGA TTLDGRKIRS KEVPYGLSDR SLSKNAYKAQ
     FWVAKKGM
//