ID F2SGV3_TRIRC Unreviewed; 430 AA.
AC F2SGV3;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 2.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=Pre-mRNA-splicing factor {ECO:0000256|RuleBase:RU369096};
GN ORFNames=TERG_01590 {ECO:0000313|EMBL:EGD85315.2};
OS Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892) (Athlete's foot
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=559305 {ECO:0000313|EMBL:EGD85315.2, ECO:0000313|Proteomes:UP000008864};
RN [1] {ECO:0000313|Proteomes:UP000008864}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4607 / CBS 118892 {ECO:0000313|Proteomes:UP000008864};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- FUNCTION: Involved in spliceosome maturation and the first step of pre-
CC mRNA splicing. {ECO:0000256|RuleBase:RU369096}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU369096}.
CC -!- SIMILARITY: Belongs to the SPP2 family. {ECO:0000256|ARBA:ARBA00008576,
CC ECO:0000256|RuleBase:RU369096}.
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DR EMBL; GG700649; EGD85315.2; -; Genomic_DNA.
DR AlphaFoldDB; F2SGV3; -.
DR STRING; 559305.F2SGV3; -.
DR VEuPathDB; FungiDB:TERG_01590; -.
DR eggNOG; ENOG502RZY8; Eukaryota.
DR HOGENOM; CLU_033338_2_0_1; -.
DR InParanoid; F2SGV3; -.
DR OMA; AWGKSAM; -.
DR OrthoDB; 55448at2759; -.
DR Proteomes; UP000008864; Unassembled WGS sequence.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:UniProtKB-UniRule.
DR InterPro; IPR000467; G_patch_dom.
DR InterPro; IPR045166; Spp2-like.
DR InterPro; IPR026822; Spp2/MOS2_G-patch.
DR PANTHER; PTHR15818; G PATCH AND KOW-CONTAINING; 1.
DR PANTHER; PTHR15818:SF2; G-PATCH DOMAIN AND KOW MOTIFS-CONTAINING PROTEIN; 1.
DR Pfam; PF12656; G-patch_2; 1.
DR SMART; SM00443; G_patch; 1.
DR PROSITE; PS50174; G_PATCH; 1.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|RuleBase:RU369096};
KW mRNA splicing {ECO:0000256|RuleBase:RU369096};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU369096};
KW Reference proteome {ECO:0000313|Proteomes:UP000008864};
KW Spliceosome {ECO:0000256|RuleBase:RU369096}.
FT DOMAIN 263..288
FT /note="G-patch"
FT /evidence="ECO:0000259|PROSITE:PS50174"
FT REGION 1..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 106..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 167..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 217..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 279..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 330..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..195
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 350..430
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 430 AA; 48139 MW; 05FEF0DE50226C5D CRC64;
MQPESSEGAS KQKPFSIALS ADSSRRSTPT PSSQSKPAAP FGTRELSSRT RRFNDHDSAS
EDEGEPVPEE VTGFDHQAGG AIISNKRVKR EKEPLTIKIE SRNKWRDKLH ARTQGMRRSL
LPAEVQAQRK REANGAAEST MEVDAPEVKV GLSYAEPSAA AVTTHTVAGD VERNGSGDHE
GAGVSVTKEE PRTKLLSQDE VALQAIIRES KGESAEFKPS DLVITARPNE NNSSAYDETK
SFRRDIESRP APASLSAYDA VPVEEFGAAL LRGMGWKEGQ PVGRGNYGNN PVTARVPERR
PGYLGIGAKD LGGKGDAEVE LGAWGKAAMR KAKNEGEGLY TPVILKSKKT GEIITEEDSE
NRQRRDRDRD RDRDRDRDRD RDRGSGRNRD KRDDQRRGHD YGRERERTHN RDRRRDRDRD
RDRRRDYDRR
//
