ID F2SHM8_TRIRC Unreviewed; 630 AA.
AC F2SHM8;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 2.
DT 24-JAN-2024, entry version 44.
DE RecName: Full=Amino acid permease/ SLC12A domain-containing protein {ECO:0000259|Pfam:PF00324};
GN ORFNames=TERG_02524 {ECO:0000313|EMBL:EGD86265.2};
OS Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892) (Athlete's foot
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=559305 {ECO:0000313|EMBL:EGD86265.2, ECO:0000313|Proteomes:UP000008864};
RN [1] {ECO:0000313|Proteomes:UP000008864}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4607 / CBS 118892 {ECO:0000313|Proteomes:UP000008864};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; GG700649; EGD86265.2; -; Genomic_DNA.
DR AlphaFoldDB; F2SHM8; -.
DR STRING; 559305.F2SHM8; -.
DR VEuPathDB; FungiDB:TERG_02524; -.
DR eggNOG; KOG1286; Eukaryota.
DR HOGENOM; CLU_007946_13_0_1; -.
DR InParanoid; F2SHM8; -.
DR OMA; IVYATIC; -.
DR OrthoDB; 1904925at2759; -.
DR Proteomes; UP000008864; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR PANTHER; PTHR43341:SF35; ACID TRANSPORTER, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR43341; AMINO ACID PERMEASE; 1.
DR Pfam; PF00324; AA_permease; 1.
DR PIRSF; PIRSF006060; AA_transporter; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008864};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 74..92
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 98..117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 190..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 215..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 289..310
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 331..350
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 370..392
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 434..452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 464..486
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 526..545
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 551..573
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 79..575
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 630 AA; 70696 MW; 077BEEF887A87CC3 CRC64;
MDPAEKPQNS LPSYHEYHTE PTMMSTDYPP TERTMVEAMV EEPTFDTEQR ARKGFSVWRV
LGERQINTRL ICRHLALTLV IGLFLGSGRS LAGAGPGGAV LCYLLMATVI SSVISCLGEM
TALMPVNAPV MEFPRRFVDR GVGFAVGWVY WFAYAVLAAD QLVAVTNSVR FRYDDGKTFL
HWETGENVHP AVWISLFLFL VTMINMLPVK YYGELEYLFG SIKLSFITMI IVMMVVLDTM
QPRSNAYYKD PVGTKYWDQP FSFICRDYKV RGEDNAVQME IKGTMGSFLG MWTTIINVIF
SYVGMDIVAA TAAESKSLAD SESMKMAARK INLRVITLYT LAMLTSSFLV PRNHPFLNGK
AQSVGSSSVF LIAVVEAGLP AVAHFFNAMY VFSAFTCAIN SMYVASRVLH TLALREQTGP
RWLTRRLQEC HLGVPLRTVF ATAGLMMIAY MGPTGGTGQR LGELATNCTV SCLIVYTAIC
GTYLCFYRTL DEAKTLGNTS QAQSGCYERD HPRYPYKSHG QWLKGAYGLF SCLILIIFNG
VGAFLETPFN VRHFLAAYIG VPVFFLLVIG YKFKKHGFHF SRWGPERSND LQNTVQVTSK
TRKGRLEFPD DGFTAENGKT FVKWIWAWMK
//
