ID F2SID0_TRIRC Unreviewed; 1538 AA.
AC F2SID0;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=NACHT domain-containing protein {ECO:0000259|PROSITE:PS50837};
GN ORFNames=TERG_01851 {ECO:0000313|EMBL:EGD85581.1};
OS Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892) (Athlete's foot
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=559305 {ECO:0000313|EMBL:EGD85581.1, ECO:0000313|Proteomes:UP000008864};
RN [1] {ECO:0000313|Proteomes:UP000008864}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4607 / CBS 118892 {ECO:0000313|Proteomes:UP000008864};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; GG700649; EGD85581.1; -; Genomic_DNA.
DR RefSeq; XP_003237130.1; XM_003237082.1.
DR STRING; 559305.F2SID0; -.
DR GeneID; 10373588; -.
DR VEuPathDB; FungiDB:TERG_01851; -.
DR eggNOG; KOG0319; Eukaryota.
DR HOGENOM; CLU_000288_6_16_1; -.
DR InParanoid; F2SID0; -.
DR OMA; ITCHGQN; -.
DR OrthoDB; 2551282at2759; -.
DR Proteomes; UP000008864; Unassembled WGS sequence.
DR CDD; cd00200; WD40; 2.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 5.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR44129:SF1; PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB SUBUNIT BETA; 1.
DR PANTHER; PTHR44129; WD REPEAT-CONTAINING PROTEIN POP1; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF00400; WD40; 13.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00320; WD40; 13.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50837; NACHT; 1.
DR PROSITE; PS50231; RICIN_B_LECTIN; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 6.
DR PROSITE; PS50082; WD_REPEATS_2; 13.
DR PROSITE; PS50294; WD_REPEATS_REGION; 13.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000008864};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 118..264
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REPEAT 653..694
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 695..736
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 737..778
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 779..822
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 823..864
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 865..897
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 906..940
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 949..990
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 991..1031
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1032..1073
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1074..1106
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1116..1157
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1158..1199
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1370..1403
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1331..1358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..34
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1331..1353
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1538 AA; 172746 MW; 6B80043EDBED22E0 CRC64;
MSSLDMDLKR RPSDELASSA KALRLEDKKD NQYNNDGDGS QYNNTSTGRQ YVADQINITE
NRIDKGENLE FLKDLRLTDP RDDKSRILDT KGGLLAKSYE WIVDFGDFKK WRSDQGSGVF
WISGSPGKGK TMLLCGIIDH LSNPGVKHIP PSFFFFQEGD SQLNNATAVL RGLIYLLALQ
HRSFLDYLQE RYSLSGGTLF ADPENFFALS NVFRNMLSIQ TTKPIYLIVD ALDECQTDLR
KLLDLICQTS STPSNCVKWI VSSRNLYDIK EVLGPFEHKV YLSLDQNDAL ISTAVNTYID
HKVNQLSRAK GYSRPVQEEV RKYLKENANE TFLWVALVCQ RLSGIKPWNT RAELHKFPPG
LEDMYGVMLG QMLKLDDSDL DFCKSILAIA MIAHRPITFA ELPSLIELEG DISGYTEWLE
DIIKLCGSFL ITRRETIYFV HQSAKEYLQT HASTEIMPSG ISDVHYGVSL RSLTILMRTL
RRDIYAQSRP GLAINQMEKP DQDPLKTVRY SCVYWAHHLH EAYTKNLQKC RDCLSRGDNI
VHQFLKRLFL YWLESLSLLR RMRAGIIAVE KLEGVLEDLG ANPNLLTLVQ DARRFVLYNQ
VLIENAPLQT YASALVFIPA KSVIKESFRM EEPKWMKTYP IMEDSWSACL QTLEAHNDTI
RSVVFSHDHK HLASASSDYS IKIWDAVSGK WEKTLKGHTN CVTSLVFSHD NNLLVSASSD
KTIRFWGAHS GKCLQTLRGH ENHVRSVVLS YDKEFLISAS CDRTIKIWNI TVGECARTLR
GHLDWVNSLA LSHKSGQRHL ASASSDRTIR IWDVDDGRCI TILKGHSDWV NSISFKQNSV
YLASGSSDKT VRIWDVATST CVKVLQGHTN WINSVAFSHN GKYLASASND ASIKIWNSDG
KCEQTLRSHS WTVTALAFSP DDQRLISGSS DRTIKVWDMS IIGKNMRVVS AHDKWVDSLT
FSRDGKFIAS ISDDWTLMIW SATTGEYMHT LGSHKDMLNG LCFSSDTHLA SASSDRTARI
WDITTGECKE TLEGHEDCVN SVDFSPDGSL LVSSSGDHTV RVWEVDTGMC IQLFEGHTDS
VGTAVFSTDG QYIASSSRDK SVRIWSTAEV ECVWVLNGHD GWVNSAVFSD DSQFVASTST
DKTVRIWHVR TGVCARVLHG HKDSVNAVAF SHSGKLLAST SADETLRIWE TGTGKCVAGI
NARILLHTVS FDPTDSYLLT KIGRVALGSL LQPKTGQPIW HGYGMSPDLT WITCHGQNLM
RVPSEHNLLC SAVFESTVAI GTESGKVFVL EFKPDMIFPS LRVEENWMID EPMAEGWQAP
PTIPFHELSA SAQATSAPPT QDGDISSEQE APGPPMQNYE VTMRRESDSD GRTPLHLAVL
SNNEQLVLQL LRDKEVDQNA KDKHSRTALF YAIQQRKTKI ALALAEKWNV ATRVVISHLN
HPAQDYKDKS LFNAIMRQNH DEIGFLIETG ANTEARGYGI WPGWKGTTLH EAAWFGTLEI
LQLMLDCGAE KYATDIGGRT PSHHPNWSRT KEISKFLS
//
