ID F2SQ35_TRIRC Unreviewed; 658 AA.
AC F2SQ35;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 13-SEP-2023, entry version 44.
DE RecName: Full=CorA family metal ion transporter {ECO:0008006|Google:ProtNLM};
GN ORFNames=TERG_04184 {ECO:0000313|EMBL:EGD87937.1};
OS Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892) (Athlete's foot
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=559305 {ECO:0000313|EMBL:EGD87937.1, ECO:0000313|Proteomes:UP000008864};
RN [1] {ECO:0000313|Proteomes:UP000008864}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4607 / CBS 118892 {ECO:0000313|Proteomes:UP000008864};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC family. {ECO:0000256|ARBA:ARBA00009765}.
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DR EMBL; GG700651; EGD87937.1; -; Genomic_DNA.
DR RefSeq; XP_003235132.1; XM_003235084.1.
DR AlphaFoldDB; F2SQ35; -.
DR STRING; 559305.F2SQ35; -.
DR GeneID; 10376438; -.
DR VEuPathDB; FungiDB:TERG_04184; -.
DR eggNOG; ENOG502QPTQ; Eukaryota.
DR HOGENOM; CLU_007127_6_1_1; -.
DR InParanoid; F2SQ35; -.
DR OMA; CNENYQV; -.
DR OrthoDB; 1358357at2759; -.
DR Proteomes; UP000008864; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:InterPro.
DR CDD; cd12829; Alr1p-like; 1.
DR Gene3D; 3.30.460.20; CorA soluble domain-like; 1.
DR Gene3D; 1.20.58.340; Magnesium transport protein CorA, transmembrane region; 2.
DR InterPro; IPR044089; Alr1-like.
DR InterPro; IPR045861; CorA_cytoplasmic_dom.
DR InterPro; IPR045863; CorA_TM1_TM2.
DR InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR PANTHER; PTHR21535; MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8; 1.
DR PANTHER; PTHR21535:SF55; MAGNESIUM TRANSPORTER ALR1-RELATED; 1.
DR Pfam; PF01544; CorA; 1.
DR SUPFAM; SSF143865; CorA soluble domain-like; 1.
DR SUPFAM; SSF144083; Magnesium transport protein CorA, transmembrane region; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008864};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 600..619
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 631..652
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 79..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 273..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..31
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..128
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..150
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 658 AA; 73509 MW; 4B4EDE801AFF21CF CRC64;
MSDSPKSDKG ETRFLTPAPE LDDHRFQAEG LPRADIMENP AARGSLESRD RPELLLPING
NTMQERAPIC RDFEHAVIDD DEEEDPGRLG VKRVSANPMG PRLGPNDARR PSVTSSRTSV
STSPPNSVEA FAEPRRRERA NTMESQMPGE RELHLHRTIS ATSHHHKTAF SNASVAHPGS
VDVRVNPTEE ADVCFPPPPF EDTGRSPIID YEELEEFVAL SKARADNISA QNGVQRKHSI
SAQSRQTLNF TGIQKGNSNV DVPEIVMTPC DMEKPNTTVH LPVDSAKDSG SDEPEDEKTG
LEAMKNINSP QRFSFFSSEF ESTVHAASIG DLVLPGDSFR DLFQLGPDGG VWWLDVVNPT
SDEMGAMSRA FSIHPLTAED IMTQEAREKV ELFRQYYFVC FRTFYQMDKI SEDYLEPVNL
YMVVFREGVI SFSFTDNPHA ANVRKRIGKL REYVSLSSDW ICYAMIDDIV DSFGPVIREI
EVESEAIEDH VYVARIEDFN LFLPKIGGLR KKVMSLMRLL GGKADVIKGF AKRCNEQYSV
TPRGDIGLYL GDIQDHVVTM MSSLGHFEKM LSRSHGNYLA QVNVTNIMVG NRVNEVLSKI
TFLASIIVPM NLICGLFGMN VHVPGQGGDD LFWFFGIVGV IILISIVSLI FARRYKLL
//
