ID   F2SU60_TRIRC            Unreviewed;       617 AA.
AC   F2SU60;
DT   31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 2.
DT   27-MAR-2024, entry version 41.
DE   RecName: Full=AP complex subunit beta {ECO:0000256|PIRNR:PIRNR002291};
GN   ORFNames=TERG_06010 {ECO:0000313|EMBL:EGD89772.2};
OS   Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892) (Athlete's foot
OS   fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX   NCBI_TaxID=559305 {ECO:0000313|EMBL:EGD89772.2, ECO:0000313|Proteomes:UP000008864};
RN   [1] {ECO:0000313|Proteomes:UP000008864}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4607 / CBS 118892 {ECO:0000313|Proteomes:UP000008864};
RX   PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA   Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA   Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA   Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA   Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA   Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT   "Comparative genome analysis of Trichophyton rubrum and related
RT   dermatophytes reveals candidate genes involved in infection.";
RL   MBio 3:E259-E259(2012).
CC   -!- FUNCTION: Adaptins are components of the adaptor complexes which link
CC       clathrin to receptors in coated vesicles. Clathrin-associated protein
CC       complexes are believed to interact with the cytoplasmic tails of
CC       membrane proteins, leading to their selection and concentration.
CC       {ECO:0000256|PIRNR:PIRNR002291}.
CC   -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC       {ECO:0000256|ARBA:ARBA00006613, ECO:0000256|PIRNR:PIRNR002291}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GG700654; EGD89772.2; -; Genomic_DNA.
DR   AlphaFoldDB; F2SU60; -.
DR   STRING; 559305.F2SU60; -.
DR   VEuPathDB; FungiDB:TERG_06010; -.
DR   eggNOG; KOG1061; Eukaryota.
DR   HOGENOM; CLU_006320_4_0_1; -.
DR   InParanoid; F2SU60; -.
DR   OMA; NPPEVQW; -.
DR   OrthoDB; 648032at2759; -.
DR   Proteomes; UP000008864; Unassembled WGS sequence.
DR   GO; GO:0030117; C:membrane coat; IEA:InterPro.
DR   GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR026739; AP_beta.
DR   InterPro; IPR016342; AP_complex_bsu_1_2_4.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR   PANTHER; PTHR11134; ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER; 1.
DR   PANTHER; PTHR11134:SF3; AP COMPLEX SUBUNIT BETA; 1.
DR   Pfam; PF01602; Adaptin_N; 1.
DR   PIRSF; PIRSF002291; AP_complex_beta; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|PIRNR:PIRNR002291};
KW   Protein transport {ECO:0000256|PIRNR:PIRNR002291};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008864};
KW   Transport {ECO:0000256|PIRNR:PIRNR002291}.
FT   DOMAIN          15..533
FT                   /note="Clathrin/coatomer adaptor adaptin-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01602"
SQ   SEQUENCE   617 AA;  69364 MW;  E49D96C632803FAE CRC64;
     MAVNRIRGAF TAPRKGETFE LRAGLVSQYA YERKESIQKT IMAMTLGKDV SSLFPDVLKN
     IATADLDQKK LVYLYLMNYA KSHPDLCILA VNTFVQDTED PNPLIRALAI RTMGCIRVEK
     IVDYMEEPLR KTLRDESPYV RKTAAICVAK LFDLNPTLCL ENGFLEALQE MIGDPNPMVV
     ANSVTALAEI SETSPETKAL QITPNTLRKM LMALNECTEW GRVSVLTNLA NYTPKDQKES
     ENICERVVPQ FQHINASVVL AAVKVVFLHM KYINPDMAKS YLKKMAPPLV TLVSSAPEVQ
     YVALRNIDLL LQSQPNILDK ELRVFFCKYN DPPYLKFQKL EIMVRIANDR NVDQLLAELK
     EYALDVDMDF VRRAVRAIGQ TAIKIELTAE KCVATLLDLI NTKVNYVVQE AIVVIKDIFR
     KYPGYEGIIP TLCQCIDELD EPDARGALIW IVGEYAEKIS NAGDILDGFV DGFNEEFTQT
     QLQILTAVVK LFLKRPDKAQ GLVQKVLKAA TEDNDNPDIR DRAYVYWRLL SNTNDPNAPK
     NVVLSEKPPI VTTIHSLPPN LLEQLLGELS TLASVYHKPP EQFVGQGKYG ADAVQKAAIE
     YDYPRLSKLA KVTNINA
//