ID F2SWV5_TRIRC Unreviewed; 316 AA.
AC F2SWV5;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 2.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Autophagy-related protein 27 {ECO:0000256|ARBA:ARBA00013776};
GN ORFNames=TERG_07054 {ECO:0000313|EMBL:EGD90827.2};
OS Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892) (Athlete's foot
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=559305 {ECO:0000313|EMBL:EGD90827.2, ECO:0000313|Proteomes:UP000008864};
RN [1] {ECO:0000313|Proteomes:UP000008864}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4607 / CBS 118892 {ECO:0000313|Proteomes:UP000008864};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004358}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004358}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Preautophagosomal structure membrane
CC {ECO:0000256|ARBA:ARBA00004472}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004472}.
CC -!- SIMILARITY: Belongs to the ATG27 family.
CC {ECO:0000256|ARBA:ARBA00005363}.
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DR EMBL; GG700656; EGD90827.2; -; Genomic_DNA.
DR AlphaFoldDB; F2SWV5; -.
DR STRING; 559305.F2SWV5; -.
DR VEuPathDB; FungiDB:TERG_07054; -.
DR eggNOG; ENOG502S1VT; Eukaryota.
DR HOGENOM; CLU_047751_0_0_1; -.
DR InParanoid; F2SWV5; -.
DR OMA; GSSHWGF; -.
DR OrthoDB; 1332975at2759; -.
DR Proteomes; UP000008864; Unassembled WGS sequence.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.70.130.10; Mannose-6-phosphate receptor binding domain; 1.
DR InterPro; IPR018939; Autophagy-rel_prot_27.
DR InterPro; IPR009011; Man6P_isomerase_rcpt-bd_dom_sf.
DR InterPro; IPR044865; MRH_dom.
DR PANTHER; PTHR15071:SF38; AUTOPHAGY-RELATED PROTEIN 27; 1.
DR PANTHER; PTHR15071; MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER; 1.
DR Pfam; PF09451; ATG27; 1.
DR SUPFAM; SSF50911; Mannose 6-phosphate receptor domain; 1.
DR PROSITE; PS51914; MRH; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008864};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..316
FT /note="Autophagy-related protein 27"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003290012"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..231
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT REGION 163..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 316 AA; 35192 MW; CE4D0C1AD601628D CRC64;
MARYKGLSIL SLFAVFSSLA SAELDCSNIK VDGVSWNFGK LGGAHSISET SSSHEGYNTT
YTLDICKPLT KSLCKKGAFV CAVRNATDIN GIERTMDVID IAGNFVLNSG RTLDPIFTRL
KQEDPNTEGL KMELHGGKHK FGNLLKRQKA VITLLCDRER TGLEGLEDPK PDGDKKKDGE
KKDDDKKGNK DKEGKSKRGD EKNKKSLIFK SYNEEHGTLD LEWRTKYACE NVEDGGSAPS
SHWGFFTWVI VLLFLCTSAY LIFGSWLNYS RYGARGWDLL PHSDTIRDIP YILRDWARRV
VNTLQGGGTR GGYSAV
//
