ID   F2T087_TRIRC            Unreviewed;       740 AA.
AC   F2T087;
DT   31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   31-MAY-2011, sequence version 1.
DT   27-MAR-2024, entry version 40.
DE   RecName: Full=Kelch repeat protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=TERG_08226 {ECO:0000313|EMBL:EGD92009.1};
OS   Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892) (Athlete's foot
OS   fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX   NCBI_TaxID=559305 {ECO:0000313|EMBL:EGD92009.1, ECO:0000313|Proteomes:UP000008864};
RN   [1] {ECO:0000313|Proteomes:UP000008864}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4607 / CBS 118892 {ECO:0000313|Proteomes:UP000008864};
RX   PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA   Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA   Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA   Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA   Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA   Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT   "Comparative genome analysis of Trichophyton rubrum and related
RT   dermatophytes reveals candidate genes involved in infection.";
RL   MBio 3:E259-E259(2012).
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DR   EMBL; GG700659; EGD92009.1; -; Genomic_DNA.
DR   RefSeq; XP_003231440.1; XM_003231392.1.
DR   AlphaFoldDB; F2T087; -.
DR   STRING; 559305.F2T087; -.
DR   GeneID; 10377634; -.
DR   VEuPathDB; FungiDB:TERG_08226; -.
DR   eggNOG; ENOG502SIX7; Eukaryota.
DR   HOGENOM; CLU_012508_1_2_1; -.
DR   InParanoid; F2T087; -.
DR   OMA; KIKEYWP; -.
DR   OrthoDB; 2358510at2759; -.
DR   Proteomes; UP000008864; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.120.10.80; Kelch-type beta propeller; 1.
DR   InterPro; IPR011043; Gal_Oxase/kelch_b-propeller.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   PANTHER; PTHR23244:SF506; HOST CELL FACTOR 2-LIKE; 1.
DR   PANTHER; PTHR23244; KELCH REPEAT DOMAIN; 1.
DR   Pfam; PF13854; Kelch_5; 1.
DR   SUPFAM; SSF50965; Galactose oxidase, central domain; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008864};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..740
FT                   /note="Kelch repeat protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003286410"
FT   TRANSMEM        506..530
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          634..692
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          704..740
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        634..671
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        706..740
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   740 AA;  81040 MW;  B28B3410C4565828 CRC64;
     MKSSSAIAGL GLAFISMVNG QGDKVQTNVD FCNWYRFRAG VIRDTVYLDG GSLLWQRNFQ
     DGRPILEKAG PDLDNMFTLS FNSSFDMKTN FTDLLGRIPR LAGGDASLLA PTYIDGTMFY
     SDYTLLTYGG ITRRPLQTPT NSSLYGYDAY QYGPFKPPFK PGSILPQIHE DVTRYITHGA
     GVSVPSENKG YYFSGRQREN GDVIDVATQP NITANTLISV DLSRFDEPKF ARDNLTGVTG
     RSNAELVWLP VSDGVMVVIG GVTNPESIYP SPISSQEKEE NTKKDSAFME TVSLYDIGTG
     EWYSQKTTGD IPPASNSFCS VVGEAADRSS FNIYIYGGYN GTERTVRPYD DVHVLSIPSF
     TWTKVYTGES NMGRRAHKCV KPYPDQMFVI GGQYTSQTSC LVGPLVRVFN LNELKFKDKY
     DPREWSGYVV PDVITKKIGG TGKGGATKTQ PDSWDNDKLG DIFGKKYTKT IQKWYPYEPA
     KATSSAPGTT APPGENKGAG GGLPRWVGAV LGVVLGLIFI TALAVVWLIF RRRKERRYAP
     SLGGTSEVAR RRILGWMYGM GQPSHKPDMT TTSTEIGIND KHASTGIYSD SGIDSVASPN
     NHPPSTIVYS DINAPEAGSS PIHEMHAGTV MSPSELPTPF NDTPVTARHP SETPSFISPI
     SPATSPSPEN QRELHHPARP THGRHGSSFS SIGVPVTLDN IVVSENTESR PRERRVSGFT
     EEFSDTHSPS YEDVETGHKI
//