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Database: UniProt
Entry: F2TX22_SALR5
LinkDB: F2TX22_SALR5
Original site: F2TX22_SALR5 
ID   F2TX22_SALR5            Unreviewed;      6625 AA.
AC   F2TX22;
DT   31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   31-MAY-2011, sequence version 1.
DT   20-JUN-2018, entry version 50.
DE   SubName: Full=Fibropellin III {ECO:0000313|EMBL:EGD75931.1};
GN   ORFNames=PTSG_00638 {ECO:0000313|EMBL:EGD75931.1};
OS   Salpingoeca rosetta (strain ATCC 50818 / BSB-021).
OC   Eukaryota; Choanoflagellida; Craspedida; Salpingoecidae; Salpingoeca.
OX   NCBI_TaxID=946362 {ECO:0000313|Proteomes:UP000007799};
RN   [1] {ECO:0000313|Proteomes:UP000007799}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 50818 {ECO:0000313|Proteomes:UP000007799};
RA   Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA   Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q.,
RA   Gargeya S., Alvarado L., Berlin A., Chapman S.B., Chen Z.,
RA   Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA   Heilman E., Heiman D., Howarth C., Mehta T., Neiman D., Pearson M.,
RA   Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S.,
RA   White J., Yandava C., Haas B., Nusbaum C., Birren B.;
RT   "Annotation of Salpingoeca rosetta.";
RL   Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; GL832956; EGD75931.1; -; Genomic_DNA.
DR   RefSeq; XP_004998107.1; XM_004998050.1.
DR   EnsemblProtists; EGD75931; EGD75931; PTSG_00638.
DR   GeneID; 16078703; -.
DR   KEGG; sre:PTSG_00638; -.
DR   InParanoid; F2TX22; -.
DR   Proteomes; UP000007799; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0030247; F:polysaccharide binding; IEA:InterPro.
DR   GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0000272; P:polysaccharide catabolic process; IEA:InterPro.
DR   InterPro; IPR008965; CBM2/CBM3_carb-bd_dom_sf.
DR   InterPro; IPR002102; Cohesin_dom.
DR   InterPro; IPR036439; Dockerin_dom_sf.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR036024; Somatomedin_B-like_dom_sf.
DR   InterPro; IPR001212; Somatomedin_B_dom.
DR   InterPro; IPR026307; TMEM132.
DR   InterPro; IPR031437; TMEM132_M.
DR   InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR   PANTHER; PTHR13388; PTHR13388; 1.
DR   Pfam; PF00963; Cohesin; 3.
DR   Pfam; PF00008; EGF; 3.
DR   Pfam; PF01033; Somatomedin_B; 1.
DR   Pfam; PF16070; TMEM132; 3.
DR   Pfam; PF00020; TNFR_c6; 1.
DR   SMART; SM00181; EGF; 9.
DR   SMART; SM00179; EGF_CA; 5.
DR   SMART; SM00201; SO; 1.
DR   SMART; SM00208; TNFR; 3.
DR   SUPFAM; SSF49384; SSF49384; 3.
DR   SUPFAM; SSF63446; SSF63446; 1.
DR   SUPFAM; SSF90188; SSF90188; 1.
DR   PROSITE; PS00010; ASX_HYDROXYL; 2.
DR   PROSITE; PS00022; EGF_1; 7.
DR   PROSITE; PS01186; EGF_2; 5.
DR   PROSITE; PS50026; EGF_3; 7.
DR   PROSITE; PS01187; EGF_CA; 2.
DR   PROSITE; PS00524; SMB_1; 1.
DR   PROSITE; PS50958; SMB_2; 1.
DR   PROSITE; PS50050; TNFR_NGFR_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007799};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00601599};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00032677}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007799};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   5752   5775       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       77    122       SMB. {ECO:0000259|PROSITE:PS50958}.
FT   DOMAIN      229    264       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      266    302       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      422    458       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      547    576       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      578    614       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      705    737       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      739    775       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN     2385   2428       TNFR-Cys. {ECO:0000259|PROSITE:PS50050}.
FT   REPEAT     2385   2428       TNFR-Cys. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00206}.
FT   COILED     6315   6339       {ECO:0000256|SAM:Coils}.
FT   DISULFID    254    263       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    292    301       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    448    457       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    566    575       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    604    613       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    727    736       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    765    774       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID   2407   2420       {ECO:0000256|PROSITE-ProRule:PRU00206}.
FT   DISULFID   2410   2428       {ECO:0000256|PROSITE-ProRule:PRU00206}.
SQ   SEQUENCE   6625 AA;  692023 MW;  D1592CEC9F029563 CRC64;
     MTAQRSSARP SVRRRGRRRK GTACRHPIGC TSSCRLNPTR AAITLLLLPA LFVCGLFTPP
     LAVQAQQDET TPATSTTVDQ STSLCALKGC GYNRLHPCQC DNECVPNGDC CPDYEQVCVT
     TTSTTTTTTT TTTTTTTLPF WQTGPSCDPN PCQWNGNCTE VMAPLTCEER CAVELDACQD
     TSQCRRSSAQ MCLTALMSVV TFDPRPCPSP DECCSTTITD PDALLIYEAA ANCIWENCDA
     DGGGSYTSNV TCACPPGRTG DLCDVDVKEC EPNPCQNRGT CIEGHNGFNC SCVEGFDGPT
     CGAFVGCDAQ ENPCQNNGTC SPVFEDAPRC VQQCAAEYLA CDQDAQCSPR KTCLLIPDGT
     QGTASLDTVL DCGLPYIMNN ASKAIFTTAA TCVVEECDLT PILEGITCGC PDGYEGDFCE
     TDINECDPDP CLNGGTCTDL IGAFFCACPT GFDGDRCQTR LNCTTESIAN MCQNNATCVS
     EPRACHRYCE PSIDACAANA DCSGPQDATL LCLQAVARAG TDQCDEACLR DCAQRFSTQA
     GEALFEDALQ CIVDDCPLLP DFRCQCPTGF EGVYCETNPD DCVEGMCLNG GTCVDGVNTA
     TCTCPASYTG PRCETLLSCE ADMCQNNSTC TDLFDVPAAI ASCSETCDNV FSACLQDDAG
     ALSCSSAFNC LLVPLSDQEH TCELDCVQEC GKLQQGTTSR QLFDAAAECV FVNCVPNLVP
     SGFKCTCPAG FTGDLCDEDI NECDPNPCSN GGTCLNLLAA YDCVCPSTTW GDNCQNLCDV
     CNTTAAAAAA ATQYQKQACT PTSNTVCAPL TPCRVGEYEA VAPTPTSDRV CEPIPVARWF
     PPTTVSVSTP ALPASTTGLT RLSATSTRAA FGFLLGGPVD TPATISASIG PSTASEQVRA
     AREPASSVTG QLLSPTRVYY DKPYVHAVIQ VRDAAQNTRV QSNTAVFVEA TAPAALRVLQ
     DVSPRQTCVV DSTSGACTVQ LALPQAWFAA QAEETVSIAF GIDGTSNGVL ADVVLVPGAD
     RVVLASEVVV ELPTHTLFPS KTFTAPIRAK NDIELALYRL SVDIDQTGLA FDADSPATIS
     DRWLHTVEAT PTGIVIVGTL AEENAAPDVD LLATLNLRVL ETTATTQPDA AQFSINVTVE
     ALGNVRSEPV AVLGRPTPTY ATHSHRQQQQ GVQFGQVHVQ PNALVTVMPY AGAGDLPNVA
     RLTGQRISHA LTVLGAYADG TTAAVSTSSG LLSCSTLNPA TLKVFADCSA VYFDGDETAG
     ADGTSIAVRV IGLGVLVPVT FRVWLPTAAE LTTDAVGPNL QAVAGLRHPA RSCQPVYQQT
     QLFCPCTFST RLLDGSTITR QVDVLPLVLA HLQQTNASVA SVSDTGVVEG LLPGTTTISL
     PAPSIVSAAT VTVGQGAAVG VRRIDAYPVA GLALSSLPSR VDRLAAHTVD IGILSNITVE
     FDTAYVTVRA VLNDTTTLPL DGFPGLNITS LDARVARVLA NPATPQRFEA VGTGSGDILR
     VDLSSTEACD AANTVIASGL SPVFISLPQP TALVVHSFKS TLAEANDVVA QLTSSSKRIS
     TSTTLGLRLV FPAYVTDAST DARVVLDTSK SGGLFTAQRR ASDGRVQVTS NSAGLTGTGT
     LTIGFSHVSV THSINITVVG TASVEARLRP WPAYAGSRGV EVHQLQQYAD TGVWQEAVLE
     TVLVLTSGER VDVSTDGAVV SYSVVAGSDV VRVSSGTVVS YTGAGTAFGN ASVEARVAGA
     VSQFVARADV AATNTSVRVV GFEGLTLAGT VVGVVGHVSR GQVDVVLSDG RKYADLIDVS
     GSGSARIGGL VAFSVKGDSS GAVAVDGASG AVTLLGNSAV ELEYVVRATV GGAMGSRMFA
     ANLQAGDGDV DLGSLSGVPV PAQQPGATFD VPVRLTSTAK VVAGLRLEVT YPPDVLEYVS
     ATQGSAYGQG LFLVTPNDPP GVLLFGGTTD GVSGSSQEVA VLRFRVADDA APPALITLGG
     TIIELIDDAS LDIVAPDTAF VAGNVSMVIL DGNLRRRRSA AGLDVSDSDD VGWSRSLLPV
     VAPRERHRRA GDAPCTGLPC AGGRHLGDAN EDCCFTLADV RFVQSFLAKR TFDPSFGSDY
     SRDRYEQMDA NINGRVDDFD PVYLIRVLFK QLHFITNVTV TPVAQSPASG ADAAVACQLR
     ISATPLGAGN TVPDPERTFL FFDVESRDTG LRPALDNSAV TRGQVVVADK GAPTFNGAIF
     QAEAAVPSGG DDMGDNETPV PHSVDMFTSL DLGDVGLTIL QVTVDQSSPP QTSDSRAVRI
     SNSTGAVEFG SPFMYQLQLG PATSYTFDLT TPYHPLQLFA NPTSSLECFV SLPACDTNVF
     FELDPPTLSS ARVCQRVREC NTTTQYETTA PTPTSDRDCA RIRGPCEPGT FQDAAPTPTS
     DRVCDNCTVC TSDMYTKTAC TILQDTVCAN LTACQPGEVE LVLPTATSDR ECGRIPDATL
     PLATVNSNTG LGYLLEQQLP TVTPAGTRGQ VGVFVDALNA DNGNLRAVLG DSEAQAAFTL
     QRSPAVSVEA QVATQRLWHD APQVNVHLVV RDALHSTNTQ QTQVSIAVTP VDFTSSVPAV
     TASCTTRSAC WARVSVPQEW FSNTTERAVQ VTYGLGSTPT QQVSSPPLPL STAPASSPLM
     ATGAAGSGGV WFSAPHRPVR PGATFQVPVY AQGGDYPVNT WQVRCSVADD ADKLVITQMS
     VDSAWDGQVQ GEGTSTVVGN GLPLGDRPEL APEQELLFTL TVAVQPQDAW TQGANASATT
     AAEVALSCTV LSLFNVEKQQ PLVTPVAAVS SGRDGVRVGD ASVFLAPAQT VGFAAMIPAA
     QLVNSAVLTG EAVNSPVSLV AFDEDSTPIT VSNNDGDVVA CASQDTDVVG VSSDCTRAQL
     LGVEARGSAS AMLTFTWRDL RATAAVAVWY PRLPLFLNIT DTTMNRVSAP GACDAWYQST
     RPRVTTVLGL ASSNATTTSV DVDVTHLVQL VSSNTTIVGV TEAFGATTLV GRSAGAVTVV
     ATDASGNGVS NSVAVSAVDS PRAFIANVRS AVVADLSIAS VPATVATGAD ASAAFAYAVV
     ATQQLTREKQ FADVALELVF TDGHTQPLAE SQVNLRSLAP GAIRVYTNTS ERTSTTQDIQ
     VLSSIVGEAV EADIVDTSEC GRLFGDDNVL LTHTINVDAQ LPLPVDVEVT ASARKIASTQ
     DPAGALLATE TTLSVALVFA DGRKQVMTTD ARTRYTVLPA TGEGMGAQAS ELLTVAQRSD
     DTVVALAASP ALAGVARVFV NFTHVNVTGE VSVEVVRAQG VSLAIRPYPS FSGSSQTTVT
     RLALLANTDV YQQAQLETRV ALSDGTSQDV STHALVEYGA EADPANANTT GVLVVGGVSP
     NRVRVQEDGV AAVSLPFNAN VTAVFAGALV ATPQPLAVTG ERTFVTAITD LSFPSTLTGI
     QNATTATIQA AVTFDDNTQL RRSHLYASGV LQVPGLLSFS TSRPAVASVD ASSGVVALHT
     NFHSAVEYTV HAAGSNGSDV VASDTFFCNL QPVSGDVDLG RTAGSPLGAQ RVGDEFDVDV
     RVRSDTAFTT LQLNVLFDER ALQPISVQQG SQLSGIFSSN IAIPGTVVIG ASVTGLSGTV
     VVASVRFRAL QSGVWAVYGE TNTLADASAT SLIANPDDPR FTAGDIQVAV VDNNARRRRS
     VLHAEAVASP QAQQQQQQQA RARRATEVCQ PACAVDEWPC ATCPNGRQFG DANGDCCFDA
     NDVTFVRQLL NQIQGDTSHP AFTSLAPFQQ AAADADGNTN VNTEDAFYML QVTTFVFSFF
     THVQVQPVSA ATDCEVLLRT GLLSIGAGRV AEAPAPPNTY VLFDVESRDT NLRAVLLNAN
     FSAGELVAFK PSPHNGAILR AAYEGDGSYA LSFAASHNVS GMGVSLFQAT IAADGVSNLF
     TGDADRRVTQ EFPPFALEFD VGDNSGLHGA VDVQSYNPLV SVTVNATTEA CLPPTKCPSN
     HYRTSPLGVQ PLTCEPYTVC ADDEVLVRNG TETTNVECEL RAFFPPYQVA SSIDALLFLS
     AAHNSTTDTN GNSGPNVAAA AATSIASVAR AAQLPTFPSA NRYRTVGFAE QFGTNPFPPA
     LDVHARVGAD QEGGDDASAA LSVPCTTTER VAPVATIGAV VLDERSVYED SAVVRVYCTA
     FAANGRSGDG VEPVEITAVV TSANSSADAP LPVSATCTAS PATGGACIAE VAIPSAWFSA
     DSDAMDVDVT VTADAVNATA VYLPSAATIV PTTASLDLSN DAMLVLPQQR LAPGETAAMA
     LNANTGASVG AFAFKVSVSG AMLEVTGAQV SSRFTAQVTQ LAPDELGIVG YLPPGSPFVT
     SEAGTESIAS ITVRAIDRQR NVQVAGAVAL EIVSLASALQ QSVRPRGEAT PTVGLTFDRD
     GVRAGAGALY IASPQPVAVM ARASRYTLWN KLPLAAAGDQ NAAEQTATTI ALYNVLADGT
     LAERDNNDNN DDASNATAST ITCTATNGDS VKLDVATCRR LLFTQNTSAP SPDVVVNMAL
     TGDDSDEQQP VPILNPALRF SVWQMVDGPH VLLDDSVLNT LPVSLATCSD VSAAPVFQRT
     RVRVAASFSD GEESTPLADV TTFVHTRIRS TDAAVATVSV SSVSGDATFI AVYAQGASLG
     TTDMVLDSAL GAGQPTSPVA ATAPLRVVAD PVNITRLYVS ATQELALDTA SPAACGATSL
     IEARSKAGLD REGQRAVLSA WMRTSDDQLV DVSAAPFVVF ASNNTNILDV QGSAAVASAA
     SVGSDSPIAV NALLFPTACT NTSSSAILAT GETLVPVFIP QPTGIEITLG DAELTLEGDP
     LTRVQAGSSS SRRPTSTTLG LRLVFPAYVT DASTDARVVL DTSKSGGLFT AQRRASDGRV
     QVTTNSAGLT GTGTLTIGFS HVSVTHSINI TVVGTASVEA RLRPWPAYAG SRGVEVHQLQ
     QYADTGVWQE AVLETVLVLT SGERVDVSTD GAVVSYSVVA GSDVVRVSSG TVVSYTGAGT
     AFGNASVEAR VAGAVSQFVA RADVAATNTS VRVVGFEGLT LAGTVVGVVG HVSRGQVDVV
     LSDGRKYADL IDVSGSGSAR IGGLVAFSVR GDSSGAVAVD GASGAVTLLG NSAVELEYVV
     RATVGGAMGS RMFAANLQAG DGDVDLGSLS GVPVPAQQPG ATFDVPVRVS AGASVLGALD
     LDIVYDPTIL QAVSIAQTSS LWEGGVFVAS LNSPPGVASF GGLLQKNAAV GVLTVATLRF
     RVLAPENGAN STSGCITAIH GVVNTIADAS SQQLTIGAPT PRAIVAGSVD VVIGTAASNA
     TTTPCTASTP GRRRRRRDSA VDTTATAVAA AAADGRVARD SESLLRARRA TPCDPASCPE
     PRMLGDVLCD CVFDIKDAGA LLRFLGRELV DPAVNRSSLS ADEKRVMDAN VNGHIDVLDV
     SFLAAVNFDL LRFVSAPRVR VLPSPDGCLL EVSVLALTAS HQAASPTDTA IVFDIEPAAG
     SGDAQRANWT LAEPLAGDLL SPGKPDGYAG AWIQAAVPFA VAPSLYRTVI PLGDTPPTNI
     SGGVSVVQLT VSTEGAFSPD RLLFMTRHVD DAPAYDTALD SQLANVTFAA DSNGQARQGA
     HVAAAVSKPQ GYSPLVGVVQ NTSVCDQPGS VDEKPLTTSF LLPLDYDAIV GNATRLAALE
     AAVLDGLWRF AGVPPSLVVR ITFSRGSVGV DVVHADGRSA DQTAYAVQQD QMKVNFEGSQ
     VAASPMPSVT TTAGPGTTAP PATGTTTTTI TAASTSSTVS LAPPGAEGST ALIVPIVPAV
     VGGVVLIMLV VLLLVHRRKQ RRKRDVELQA HEDALRREQQ FGHIVASPTK DRHSLYLGVA
     TGLDHHEVPM NPLHEDNVQQ DVGHYRGLDG AAGRLPSVGR AMRLPARSTV SPMQSPRGSR
     AGTSSVSSTP GHSKEQEQQQ QKQRGSEAAS SFSPLESPTR RPSAWEFASN REVASGIARL
     TEGLVYGINR GALQLQRNIS GGDSQLDATT DFIDLSGSLP GDARTDVFDF PSEAGETTTD
     PRTGGIMLRD GAATTYARLL NPAPQPMYQQ QHGQGEEVKY AELSLVDTES YTFDVQYLDH
     RTHVHTEVHR ACWKELQETF MSIVHHTVTP QAAFLTLTPE ALRIKGQPEE PFCSCALTSI
     CECRVETAHV FIGVEDAVDP SLIACHVIRM TDDDSAQRLF GLLAIACHKR YRELKGSELL
     RAEPVFSSIA VDPNASLVDT SQVTVDITDD DAWAAPTFDD DDDDEERHGQ QQRDGGSSSD
     SDTDEDDFDG VIRALRAADE LKRREGDQHA AEAQSRQPTQ AFVTSTPVAT RGVGLEQHGQ
     FEESSIMSSS RDARLETVME EDEEDEEEAR RAAAERKRQR EAAYTSSVGT AAEPTRSQHV
     DSVHAGTAAT GSSQQPEDDD DDVWNLDEVA ELALATDDMS HPSVTGAKPG YLDVSPQQQQ
     QQMQHATGDK RGYLDVAPKP GAATTQRPGY LDVTPKAQQK RGYLDVAPDQ QHVRADTSPG
     YVHVQPQSPA TPSSSSTGLQ THVPLYADVS GLHDSRRSEE PAYINVSVAM PEHHQHQQQR
     HPDQPSFNRS GDFPFTPEIR PPPGFEQQQQ QQQHESTPMA PSQRAAQHHH HGGGGYGGGH
     HHRRDMHGED EEEDMNDLRE MLRDM
//
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