ID F2TXE3_SALR5 Unreviewed; 1859 AA.
AC F2TXE3;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Myosin VIIa {ECO:0000313|EMBL:EGD76052.1};
GN ORFNames=PTSG_00762 {ECO:0000313|EMBL:EGD76052.1};
OS Salpingoeca rosetta (strain ATCC 50818 / BSB-021).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Salpingoeca.
OX NCBI_TaxID=946362 {ECO:0000313|Proteomes:UP000007799};
RN [1] {ECO:0000313|Proteomes:UP000007799}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50818 {ECO:0000313|Proteomes:UP000007799};
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "Annotation of Salpingoeca rosetta.";
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; GL832956; EGD76052.1; -; Genomic_DNA.
DR RefSeq; XP_004998227.1; XM_004998170.1.
DR STRING; 946362.F2TXE3; -.
DR EnsemblProtists; EGD76052; EGD76052; PTSG_00762.
DR GeneID; 16078823; -.
DR KEGG; sre:PTSG_00762; -.
DR eggNOG; KOG4229; Eukaryota.
DR InParanoid; F2TXE3; -.
DR OMA; HYDVRGI; -.
DR OrthoDB; 1094820at2759; -.
DR Proteomes; UP000007799; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13202; FERM_C_MyoX; 1.
DR CDD; cd17110; FERM_F1_Myo10_like; 1.
DR CDD; cd14873; MYSc_Myo10; 1.
DR CDD; cd13297; PH3_MyoX-like; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 4.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR041797; MyoX_FERM_C.
DR InterPro; IPR040640; MyoX_N_SH3.
DR InterPro; IPR036124; MYSc_Myo10.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR46049; AGAP003327-PA; 1.
DR PANTHER; PTHR46049:SF3; MYOSIN MOTOR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00612; IQ; 2.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00784; MyTH4; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF18597; SH3_19; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00295; B41; 1.
DR SMART; SM00015; IQ; 3.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 1.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 4.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50096; IQ; 2.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW Reference proteome {ECO:0000313|Proteomes:UP000007799};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 62..736
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1014..1115
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1203..1303
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1339..1510
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1515..1858
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 616..638
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 842..934
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 156..163
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1859 AA; 211760 MW; A4778830FF5AA389 CRC64;
MSFFEDGSRV WVKTAETWVP AVAAGNDGTQ SSFKADDGQV HVVPNESIGP DTVTAMHETS
QNGMEDMAQL ADLHEGSLLY NIALRFKQNK IYTYIGSILS AVNPYQRFNE LYGPEKIEEY
KGKTIGDLSP HIYAIANEAY HAMWKNDANQ AILISGESGA GKTESTKFIL SFLSHLSNTI
NDSKGVTAAK NYEEQIVLSS PILEAFGNAK TVYNNNSSRF GKFIQLAFSS GGTVEGAKII
DYLLEKNRVV RQNENERNFH VFYCLLASDK LDKLYLEADP SKYHYTSQSG VWTADGIDDG
EDHARLLKAF EAMSFTQEQQ DDIFKILAAI LILGNVNFVN QGGAHVVTRD VLQQCSELLG
VEADDVAEIL TQQKRVLRGE EIFTPLEVDQ AADSRDSLAM ALYARTFKWI ISKLNLSLKG
QESFHFVGVL DIFGFENFEH NSFEQFNINY ANEKLQQYFN RHIFSLEQLE YNKEGIDWSD
IDWVDNAECL DLIERKLGVL SLIDEESRFP KGTDNSLLVK LHSSHGNEDS PHYIRPRMQN
TLFGIRHFAG DVMYDVSGFL EKNRDTFRED LLEVLRESNS DFVYDLFEHD SSRGGGKRPG
TARKKPTVSF QFKESLHHLM SMLGVASPFF VRCLKPNTKK VAQQFEHNIV LNQLRYSGML
ETVRIRRAGY PVRREFSDFL FRYRVLSSGI DSNLPMPDQS KALLAKFDAN AKDWQIGKSK
VFLREGLEVE LEKERHVSLK ATVQKIQAVI LGYIQRKRYK IMLRNARRIQ AWVQMVLTRR
QYLKEKAAAI KIQAVYRGYR ARVLRAQLEE ERRIEEERRR EEERRREEER LAEIARLEAE
AKAAAEAEER EQQEAQRRLE EARQRQEEEA KRRQEEEAQR KADEDRRLAE ARERAKVLEQ
EQRQREEEAR RKAEEERLAA EEAERQRQME EEAQRLEEQR MAEEARREEE RMQAMRDAEA
EAALEEAEGM MDEEIEEEHH EGYLAMFRGV LQNLKSKWCV LHGNTFMFFK KQQDSIHAGF
LTKMGGGTST LGRKNWKRRW MALKGGKLHY YPSQDEKDEL GVVDIQNCIE IICDDLPLKK
EHAFAIDTGK RTYFMYADSE EEREEWLEIL GMVKGKSDAE LAQMMETASV NPRNAQGTID
VDDILSVGPA HSDIDGHPSF VVMTAERVYK FVARDQGEMQ AWIKVLSPKK RDPTSDLDGG
DTAVVERGWM LKAGGKGNAF KRRRWFILRG DVISYYKTPA DDLPVATIPL NSLCSVIPPD
EAEAARAGEW TFTVHSRHKT FYLTCKTQAD ANRWINAIQD VIDNSPLMEM PMEKLIDELK
LASPQEADQI YATHKLLTYS SKPLKGSLLP LPYGEITSPS GARAYETLEA EAVKLSASLL
PAVETGGRGG RFGSPENPAE LIRNVLQLCF DVPKMRNEAY CQVIVQTTNA PNPGSQLNLT
HWHLLAAMCC SFLPSRKFVR FLRFHLKRTI DHLEQVGEEV VNIAAFCLEA LKHTKTRDFP
PSTKEIEAIM SGKGLSCTVF CVNGRTVDMP ITSSTTCADV INYVKDELDL TQCRNGFGLF
ETCGSVSKYL EEKYTVADVL SKWEKYEAHG INPEGGSWRL TFKLFAFYDP IAPDLSITEK
EFLFEQAFEN VMNHRFPADD ATHIKLAALR TQYVVGDHEA GAYMSSLVKV HPAQQPQLLA
DTAATGGSTL KRAGTMIKGT LKGLGRNTIR RLRGGTLKKS EQVSDAELKK INDKIVKDWE
HMRGMSKDDA REAYMQIIQA WEGYGCNLFE VVQTTKKEWP KELWLAISLE GVGIFPRNQS
QRLAFFKYET ILSFGAPQAN QYKILVDGGP GAMVFETNMV LEIAKLMKEY IKEIVHRRG
//
