ID F2TXF2_SALR5 Unreviewed; 381 AA.
AC F2TXF2;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Cathepsin {ECO:0000313|EMBL:EGD76061.1};
GN ORFNames=PTSG_00770 {ECO:0000313|EMBL:EGD76061.1};
OS Salpingoeca rosetta (strain ATCC 50818 / BSB-021).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Salpingoeca.
OX NCBI_TaxID=946362 {ECO:0000313|Proteomes:UP000007799};
RN [1] {ECO:0000313|Proteomes:UP000007799}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50818 {ECO:0000313|Proteomes:UP000007799};
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "Annotation of Salpingoeca rosetta.";
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR EMBL; GL832956; EGD76061.1; -; Genomic_DNA.
DR RefSeq; XP_004998236.1; XM_004998179.1.
DR AlphaFoldDB; F2TXF2; -.
DR STRING; 946362.F2TXF2; -.
DR EnsemblProtists; EGD76061; EGD76061; PTSG_00770.
DR GeneID; 16078832; -.
DR KEGG; sre:PTSG_00770; -.
DR eggNOG; KOG1543; Eukaryota.
DR InParanoid; F2TXF2; -.
DR OMA; VYYDEEC; -.
DR OrthoDB; 5472948at2759; -.
DR Proteomes; UP000007799; Unassembled WGS sequence.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411:SF971; CATHEPSIN L-RELATED; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000007799};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..381
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018744791"
FT DOMAIN 20..80
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 106..305
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 381 AA; 40814 MW; 6FBF79DB9395FFDC CRC64;
MMLKIAVLLA MAVAANAMSF DDFKTTFEKQ YESPEEEARR FAIFADNLAF IARHNAEAAR
GLHTHTVGVN QFADLTNEEY RQLYLRPYPT ELLGRERQEV WLDGPNAGSV DWRQKGAVTP
IKNQGQCGSC WSFSTTGSVE GAHAIATGNL VSLSEQQLVD CSGSFGNQGC NGGLMDNAFK
YIISNGGLDT EQDYPYTARD GVCDKSKESK HAVSISGYKD VPQNNEDQLA AAVEKGPVSV
AIEADQQSFQ MYSSGVFSGP CGTNLDHGVL VVGYTSDYWI VKNSWGASWV TRGGCHSGEQ
AVRIEGISGS FCSPSCSSTS PCPTNVPPGT TAQPECVLET QGSSQPTNCA LICNPEENDG
GCPQNASCKP IQGVGICTYD S
//
