ID F2TXQ5_SALR5 Unreviewed; 1450 AA.
AC F2TXQ5;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=TKL protein kinase {ECO:0000313|EMBL:EGD76164.1};
GN ORFNames=PTSG_00871 {ECO:0000313|EMBL:EGD76164.1};
OS Salpingoeca rosetta (strain ATCC 50818 / BSB-021).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Salpingoeca.
OX NCBI_TaxID=946362 {ECO:0000313|Proteomes:UP000007799};
RN [1] {ECO:0000313|Proteomes:UP000007799}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50818 {ECO:0000313|Proteomes:UP000007799};
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "Annotation of Salpingoeca rosetta.";
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL832956; EGD76164.1; -; Genomic_DNA.
DR RefSeq; XP_004998339.1; XM_004998282.1.
DR STRING; 946362.F2TXQ5; -.
DR EnsemblProtists; EGD76164; EGD76164; PTSG_00871.
DR GeneID; 16078934; -.
DR KEGG; sre:PTSG_00871; -.
DR eggNOG; KOG0192; Eukaryota.
DR eggNOG; KOG0197; Eukaryota.
DR eggNOG; KOG0379; Eukaryota.
DR InParanoid; F2TXQ5; -.
DR OrthoDB; 5018984at2759; -.
DR Proteomes; UP000007799; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 1.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR44329:SF313; MIXED LINEAGE KINASE DOMAIN-LIKE PROTEIN; 1.
DR PANTHER; PTHR44329; SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED; 1.
DR Pfam; PF07699; Ephrin_rec_like; 1.
DR Pfam; PF13415; Kelch_3; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 2.
DR SMART; SM01411; Ephrin_rec_like; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF117281; Kelch motif; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000313|EMBL:EGD76164.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007799};
KW Transferase {ECO:0000313|EMBL:EGD76164.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 950..972
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1014..1445
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 542..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1286..1306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..562
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 563..580
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1450 AA; 160446 MW; 2C240159EC0A1ED7 CRC64;
MAVDTPVPLK PATQRRTATA TTAMGIAAAV VAVLGIAISV VPCELAHARV IIPYNAPELV
TSKTATPPSL AWHTTTLLAL ESDFISVTVG GGNANDIANN RATIRLSDDI WVFSRKLNLW
SVCEIYSGAA NASDPRFRTR MHHAAERITP LSVYNTSSPA RRPLREGAGK LMVLGGAVYI
DNNVTILDDH WMLEVWRSPI ETQSFFTCAW TRLEKPAAMA PRFLPAVSAA YHPFELYSFG
GCLEARRRHI DVGDTTEIFL ECTDTTNEVW RYTEDLGWSL LAQAVPADSA SLLRPLLSSL
MYRVGGRVPR TYMIYGGFPG RASPYVANVS MCTFPDPHAA TGSTTFSCQA LGSACVFNQY
RECKDEVRFV SRGAVIPLGN NRTVLFGVPD GISDSLVGFL HEYSTDEPAP RFTEIRSLSR
LLTPVFSGAS SRIGLLGGFS ATPLAAGIDV EQFLFFGDFF RPQTGDAWST WLYTPQSLTA
HSHAPVLSGV WQDKFFYSSM TARAWPSSQT VGHWVIQLGG YTGSVANSDW KFDVGGVLEA
ERKEREKQQQ EEDKAKGESM EDDDDHDHDD DDEEEPVNPE DVVVFDEENV DAEALTVWVR
LDELDQHTSP FSRFYGSSAT VNDSAMFVFG GQRKPRSGCA NDAFFFFPET HRVVVQEGGP
RPAERRGSTL VRMGSSIYLY GGEDCDNEFF LDDLWRFDLH LMRWFQLSRA ATAPIASSYH
TAAALKTSEN VTEMAVFGGF RPRNEYDHFG WAFNPQTQAW RPIESDEEPL WRTSHCAVRM
DEGPIAGQLV MIGGASRLGV DLGDGWLYHH ASQRWQRLRD NHVRFSLSPG RLGHTCSAFR
DTVFVFGGTS RQRFFRSVIA FRPTCNPGFS ADNGQCVPCP LRTYRSDLSN PSCVQCSGDL
TTKTEGATDV SLCNICRDSA CVHGTGTAVA SDCICRCSFG YSGKACDINV LGIVLGTLFA
LAVIGFATWH VLRFYRRVAT SIKQHSALQQ RLLDEKEQEI ELFEQIWTIS PDELQFVRVL
DEGAFGRVEL MVWLSAGLNV AVKRLREAIL QLDDTCKQDF EREVKFVRQL RHPNIVRFHG
AYLGAQPFLV MEYVERGSLQ TILADNAVPI SDARKHSFLC DTAAGMHYLH QKGRMHRDLK
SANLLVTMDW RIKVTDFTTA KNVVQDALTR QRRASQVSAG MAHARNATMS ALGRQHVEGT
RGGGQGGCSW LDADKKASTM GKVCGGLERT ACKFTRGMRR RGQAKSMSVL PRSDGGDKFD
FDELPVSLQA QAQHERRDTG QQLLVADLDD GDGNDETTTD SGGGLEGAML LTTDSDDEDA
VVIGERPSPA ATQRNEADYA NIWNQTTGIG TIPWTAPEAL ADKAYGLPAD VYSYGIVISE
ITTRRLPYWD YKGSIRKGVL AGLRPTMPED CCDRRYIDLA AQCWCENPQE RLTFSQIVTT
LQSFDGESSL
//
