ID   F2U1E6_SALR5            Unreviewed;       662 AA.
AC   F2U1E6;
DT   31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   31-MAY-2011, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   RecName: Full=ribonuclease P {ECO:0000256|ARBA:ARBA00012179};
DE            EC=3.1.26.5 {ECO:0000256|ARBA:ARBA00012179};
GN   ORFNames=PTSG_02169 {ECO:0000313|EMBL:EGD81448.1};
OS   Salpingoeca rosetta (strain ATCC 50818 / BSB-021).
OC   Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Salpingoeca.
OX   NCBI_TaxID=946362 {ECO:0000313|EMBL:EGD81448.1, ECO:0000313|Proteomes:UP000007799};
RN   [1] {ECO:0000313|Proteomes:UP000007799}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 50818 {ECO:0000313|Proteomes:UP000007799};
RA   Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA   Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA   Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA   Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA   Birren B.;
RT   "Annotation of Salpingoeca rosetta.";
RL   Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage of RNA, removing 5'-extranucleotides
CC         from tRNA precursor.; EC=3.1.26.5;
CC         Evidence={ECO:0000256|ARBA:ARBA00000928};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC   -!- SIMILARITY: Belongs to the PPR family. P subfamily.
CC       {ECO:0000256|ARBA:ARBA00007626}.
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DR   EMBL; GL832959; EGD81448.1; -; Genomic_DNA.
DR   RefSeq; XP_004996652.1; XM_004996595.1.
DR   AlphaFoldDB; F2U1E6; -.
DR   STRING; 946362.F2U1E6; -.
DR   EnsemblProtists; EGD81448; EGD81448; PTSG_02169.
DR   GeneID; 16077244; -.
DR   KEGG; sre:PTSG_02169; -.
DR   InParanoid; F2U1E6; -.
DR   OrthoDB; 2969930at2759; -.
DR   Proteomes; UP000007799; Unassembled WGS sequence.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004526; F:ribonuclease P activity; IEA:UniProtKB-EC.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.11980; -; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR033443; PPR_long.
DR   InterPro; IPR031595; PRORP_C.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR13547:SF1; MITOCHONDRIAL RIBONUCLEASE P CATALYTIC SUBUNIT; 1.
DR   PANTHER; PTHR13547; UNCHARACTERIZED; 1.
DR   Pfam; PF17177; PPR_long; 1.
DR   Pfam; PF16953; PRORP; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007799};
KW   tRNA processing {ECO:0000256|ARBA:ARBA00022694};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          222..331
FT                   /note="Pentacotripeptide-repeat region of PRORP"
FT                   /evidence="ECO:0000259|Pfam:PF17177"
FT   DOMAIN          431..649
FT                   /note="PRORP"
FT                   /evidence="ECO:0000259|Pfam:PF16953"
SQ   SEQUENCE   662 AA;  71972 MW;  D41E79A6BEC61EDB CRC64;
     MMWARLATRG GGLCALCGGG GGGSVRWARS RSTLWNTGHV ARAHSVLAPA ATAVTGTAAP
     VTEVAPTTAP PKTTTTPTTC TAAASSKTTT TPTACTAAAS STATAAPTTT AAVAPVTTTA
     TAPVATVGTC TTGAMMTRMM ASIRHLHRSS AAWRTSTYSS ASVGSAASTA TVAAALTESE
     RADIRRILSK DARVLTLSGD HGDSESTSQP KLVSKHPMLG DIHRATKDLD VDMASVLLQK
     SVALADQGIL LPDTSFHSLL YIFATANLPL KAFQTYEMLL SVGYQPSENV LSKLVALCAS
     NNDLDLAQDV INTMRRFNIV PHYRTFWKLI ETRARVDATV AIEEVSRVMD ELRMPYPGHS
     AYESMNDVLA VVVECAVQQL CGDERVQQLA VLFRLFETSN QPLGERLCAA ILEHVGRSDE
     WDVAPTTIEQ HTGRCMSCAD ALRPIALSDD DLSQLSGAVT QYLQHERVPD TEVASLKQMI
     ENLGDVEIFI DGLNVGHFGV KAFQLDLVLA VAHQLKAAGY SYVVVLRRHA IKRTNRWQQA
     RIDELQDEGR LLLLADKLSD DIRFICAAVQ LRPHSYVLTN DMFRDHMYRV SKIPGGHLFD
     RWRRGHCISY DMVYKRGSRQ PTINLMWPPK HDNVAQPTET AWHLPCVDNT WLCCAYADQL
     VG
//