ID F2U1Y9_SALR5 Unreviewed; 457 AA.
AC F2U1Y9;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 08-NOV-2023, entry version 43.
DE RecName: Full=Fluoride ion transporter CrcB {ECO:0008006|Google:ProtNLM};
GN ORFNames=PTSG_02357 {ECO:0000313|EMBL:EGD81641.1};
OS Salpingoeca rosetta (strain ATCC 50818 / BSB-021).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Salpingoeca.
OX NCBI_TaxID=946362 {ECO:0000313|EMBL:EGD81641.1, ECO:0000313|Proteomes:UP000007799};
RN [1] {ECO:0000313|Proteomes:UP000007799}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50818 {ECO:0000313|Proteomes:UP000007799};
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "Annotation of Salpingoeca rosetta.";
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Fluoride channel required for the rapid expulsion of
CC cytoplasmic fluoride. {ECO:0000256|ARBA:ARBA00002598}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=fluoride(in) = fluoride(out); Xref=Rhea:RHEA:76159,
CC ChEBI:CHEBI:17051; Evidence={ECO:0000256|ARBA:ARBA00035585};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76160;
CC Evidence={ECO:0000256|ARBA:ARBA00035585};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43)
CC family. {ECO:0000256|ARBA:ARBA00035120}.
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DR EMBL; GL832959; EGD81641.1; -; Genomic_DNA.
DR RefSeq; XP_004996845.1; XM_004996788.1.
DR AlphaFoldDB; F2U1Y9; -.
DR EnsemblProtists; EGD81641; EGD81641; PTSG_02357.
DR GeneID; 16077438; -.
DR KEGG; sre:PTSG_02357; -.
DR InParanoid; F2U1Y9; -.
DR OrthoDB; 162264at2759; -.
DR Proteomes; UP000007799; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:1903425; F:fluoride transmembrane transporter activity; IEA:UniProt.
DR InterPro; IPR003691; FluC.
DR PANTHER; PTHR28259; FLUORIDE EXPORT PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR28259:SF1; FLUORIDE EXPORT PROTEIN 1-RELATED; 1.
DR Pfam; PF02537; CRCB; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007799};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 33..52
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 64..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 90..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 301..321
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 327..345
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 357..380
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 392..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 429..455
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 201..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..245
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 457 AA; 47332 MW; 045AF165AD4C9F96 CRC64;
MMTRKADAAT SSKECLLCGG GGGGNHGRMD TGAGWVAAFS ASALGAAIRY FIAVLSGYTQ
NDAFPSEHAL ILGCAVMGAV SVVQRRISKW LAFIVATGFA GCCTTFSSWQ LEAGALLFGQ
PVEVLVIEPD SPTEQALSWL SLLVSGVFVS LGAFGAGRVL ALACITAHGD VAPLPTTLSA
SAAPKTDAQL ETILQHMLSD NAGSNGSTAA ADADGETAAA STAQQEQVED LDPSLSDDDD
EDGDAGDRAP SPLSGTATMA ATTATPATAV TAPQQPTYVV DSPPPAVAGA DVSPTPERLP
LVALAFVVPV VAITIACLSV DNTQHVGVVW IMIFALPGMM IRHWLCTRIR PRRYKHVFYF
NGTLIANMLG TVALALLGIL RDQKSLFDTS SLASAASVSV GLQVGFCGSL TTVSSMVNDA
YKLMDSRPGL ALAYLAWSVV LAQALLILVF GTYAWTR
//