ID F2U460_SALR5 Unreviewed; 1282 AA.
AC F2U460;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=R3H domain-containing protein {ECO:0000259|PROSITE:PS51061};
GN ORFNames=PTSG_11962 {ECO:0000313|EMBL:EGD82426.1};
OS Salpingoeca rosetta (strain ATCC 50818 / BSB-021).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Salpingoeca.
OX NCBI_TaxID=946362 {ECO:0000313|Proteomes:UP000007799};
RN [1] {ECO:0000313|Proteomes:UP000007799}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50818 {ECO:0000313|Proteomes:UP000007799};
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "Annotation of Salpingoeca rosetta.";
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL832961; EGD82426.1; -; Genomic_DNA.
DR RefSeq; XP_004995662.1; XM_004995605.1.
DR STRING; 946362.F2U460; -.
DR EnsemblProtists; EGD82426; EGD82426; PTSG_11962.
DR GeneID; 16076246; -.
DR KEGG; sre:PTSG_11962; -.
DR eggNOG; KOG2044; Eukaryota.
DR InParanoid; F2U460; -.
DR OrthoDB; 167745at2759; -.
DR Proteomes; UP000007799; Unassembled WGS sequence.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:UniProtKB-UniRule.
DR CDD; cd18673; PIN_XRN1-2-like; 1.
DR CDD; cd02325; R3H; 1.
DR Gene3D; 1.25.40.1050; -; 1.
DR Gene3D; 3.40.50.12390; -; 2.
DR Gene3D; 3.30.1370.50; R3H-like domain; 1.
DR InterPro; IPR027073; 5_3_exoribonuclease.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR041412; Xrn1_helical.
DR InterPro; IPR004859; Xrn1_N.
DR PANTHER; PTHR12341:SF41; 5'-3' EXORIBONUCLEASE 1; 1.
DR PANTHER; PTHR12341; 5'->3' EXORIBONUCLEASE; 1.
DR Pfam; PF01424; R3H; 1.
DR Pfam; PF17846; XRN_M; 2.
DR Pfam; PF03159; XRN_N; 1.
DR SMART; SM00393; R3H; 1.
DR SUPFAM; SSF82708; R3H domain; 1.
DR PROSITE; PS51061; R3H; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000007799};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1282
FT /note="R3H domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003290706"
FT DOMAIN 517..581
FT /note="R3H"
FT /evidence="ECO:0000259|PROSITE:PS51061"
FT REGION 580..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 813..850
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1089..1282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 866..916
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 581..599
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 819..840
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1156..1171
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1233..1261
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1282 AA; 144470 MW; 7F988751E9114E25 CRC64;
MVRAIAVLLI AVLVPGVSIH PMHWPVVLLT LTRFDPSLMA RALVGVPSFY RWLSRKYPKC
VKDVVEDRPQ NIGGEYVPVD ISQPNPNKRE FDNLYLDMNG IIHPASHPED RPAPETEDDM
FVAVLEYLDR VVACVRPRKL LFMAIDGVAP RAKMNQQRSR RFKSAKVCLN AVLWWGCVVG
GGGVCISVCV CVTFDSNVIT PGTPFMDKLA EYLRCFIHEK VSSDPGWTGI KVILSDATVP
GEGEHKIMDF IRRQRAHPEY DANTSHVIHG LDADLILLAL ATHEPHFTIL REEVTPRNRE
KSAQEKAMAA LAVRRVCIWI FLQVNVLREY LEKEMRVADF SAAGGFDLER VIDDFVFMCC
FVGNDFLPHL PSLKINEGAI DTILDLYRKD FPAFGGYLTQ SSEVNLERVQ LLLHGLAEVE
NKILSDRRFK EQRRKQKDVD ITNKKTTREH LQLILDCALS PPQLPIGDSE PPQKRPHMQQ
RVTDLSSIHH LSSEHFRIKN RGPGGVRVLR PDVDERSANR LRLLDRIREF ADAHPRKAKM
DLKSLRSFER ALAHAYSEEL GLGHRSEGEE PNRYLVITHP EVEDEDDDDE DEEDEDDDGS
AARDALKAAV KERLRNMNDK RVEQHEEQVN LGLHGYHERY YKLKFGDSVQ PRDVARAYVE
GLCWVMKYYY EGCPSWNWFY PYHYAPFAQD FVDVAGMSIR FDGGSPFTPF QQLMAVFPPA
SSHALPQAYR NLMLDPKSPI ADFYPREFEL DFDGARFAWQ AVALLPFIDE TRLLTAIAPL
ESTLTEEERR RNARGVNLLH VHQRHPLALQ VVPLDPDFSG DDNDAREHQQ QQKEQEENKQ
SPGEAATAEQ AGTPLLSEAE QNALAAEQLQ AELMGDYERA DELKRKLEAA QQQQQQQQQQ
QQQQQQQQQQ QQQQQQSGNV VVNATDAAAA EAYKTSLPQG AEEIRDVSQT GISGFVRYSQ
LSVGLGVLYT PPEFKGKNTD SVYLLKAFTN RTAMSQYYFP APCKHQSRIL PACTLPTPVL
DNLDTINFPR FVSVPRGGYH GGPPMMHGRS RVPSQFQLAV APGGGGGGFP AGPRPGVHYR
NQITAAFHAP PLLPTGPQQH APYPHHDSYQ RDPYAAALPP PSHRPPYRPP AHAHGRGTYP
APGRAPTRPP SQLTQPYLGS RPPPPGSVYR PSYPPAHAGS RPPRAVYGGP DRHAAPYQPQ
PPGQGYRRYP DRQRDYADYG ATRSDQYVPS RAYGSRPPPP PHQQRTYPAS HGGPPPPAPQ
QQQQQQQQQQ GYRPTHFPSA RK
//
