ID F2U529_SALR5 Unreviewed; 797 AA.
AC F2U529;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=mRNA m(6)A methyltransferase {ECO:0000256|ARBA:ARBA00012160};
DE EC=2.1.1.348 {ECO:0000256|ARBA:ARBA00012160};
GN ORFNames=PTSG_03395 {ECO:0000313|EMBL:EGD82745.1};
OS Salpingoeca rosetta (strain ATCC 50818 / BSB-021).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Salpingoeca.
OX NCBI_TaxID=946362 {ECO:0000313|Proteomes:UP000007799};
RN [1] {ECO:0000313|Proteomes:UP000007799}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50818 {ECO:0000313|Proteomes:UP000007799};
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "Annotation of Salpingoeca rosetta.";
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-
CC methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:55584, Rhea:RHEA-COMP:12414, Rhea:RHEA-COMP:12417,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:74411, ChEBI:CHEBI:74449; EC=2.1.1.348;
CC Evidence={ECO:0000256|ARBA:ARBA00036277};
CC -!- SIMILARITY: Belongs to the MT-A70-like family. {ECO:0000256|PROSITE-
CC ProRule:PRU00489}.
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DR EMBL; GL832961; EGD82745.1; -; Genomic_DNA.
DR RefSeq; XP_004995981.1; XM_004995924.1.
DR AlphaFoldDB; F2U529; -.
DR STRING; 946362.F2U529; -.
DR EnsemblProtists; EGD82745; EGD82745; PTSG_03395.
DR GeneID; 16076568; -.
DR KEGG; sre:PTSG_03395; -.
DR eggNOG; KOG2098; Eukaryota.
DR InParanoid; F2U529; -.
DR OrthoDB; 179166at2759; -.
DR Proteomes; UP000007799; Unassembled WGS sequence.
DR GO; GO:0001734; F:mRNA (N6-adenosine)-methyltransferase activity; IEA:UniProt.
DR InterPro; IPR007757; MT-A70-like.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR12829; N6-ADENOSINE-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR12829:SF2; N6-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF05063; MT-A70; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51143; MT_A70; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:EGD82745.1}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007799};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EGD82745.1}.
FT REGION 24..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 679..797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..432
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..455
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..481
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..501
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 509..530
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 581..633
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 727..783
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 797 AA; 88790 MW; BD49D67F3C6FEDBC CRC64;
MDATELEDAP VDDVLDAIFG VLPGSHASFG SKDRQAGNDG QGDRSDADGD SEDADDLGQT
HQEKETREVL KELDTLLNTP TVMERAIEEE FRLNGKDVFL FCDHDTAEEC AQQSVSGMPC
DRLHFRRVIQ PHTTHRYGNC RYLDRCFDMR TCKAVHYDVD ESDVECIRRR LKHKRELARQ
RPDLEAHIDL NVFRTFPAQW IQCDVRYIDF SVLGKFSVIM ADPPWRINME LPYGTMSDEE
MRQLPVQDLQ DNGVIFLWVT ARCVDLGREL LKRWGYNYAN DLIWIKINQL QNLVRTGRTG
HWMNHAKEHC MIGVKGNLDG IYPGIDCDVL VSEVRDTSRK PDEIYGLIER LSPGTRKIEL
FGRPHNVQSN WLTLGDQLQG VQLEDDALVQ RFTERYPYSP ADTLSLLLQN KLPSSSTAHK
ARGEEHSDVD TSAGPRARQQ SHRHQHNHRH QHHLDDSHNR HSQAHHHQER PSSRHRPSHQ
HRHHDDGGGD DSAERASRSG RARTPLRTVH TQRRRDSSEG RDEPVAVRGR SRSVGRDALQ
AYGGGRSASV SGGHSKADEL MHTYGHHGPR RHDRQHQHQF RSSPRQQQLQ HVYYQQRKPG
SIPESRSMSV DRTTSHGSSR GSGDGNDTGH NASAGNRPVF VPRSNAVEGE VVLNLRGHSG
YWKRDRHGSK IFIRVLPKRK DDDDDDGGDD GGAGDDGGDD VDGGGGGVDG GDGDTPLVPP
AQQSPLAASV APHTGSVTPP TPQTRQTVSP TPPQTGVHAD ATTTAPSAAP TAANTTATPA
TLPASWSAAD LWGDKVE
//
