ID F2U8R2_SALR5 Unreviewed; 687 AA.
AC F2U8R2;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
GN ORFNames=PTSG_04500 {ECO:0000313|EMBL:EGD72770.1};
OS Salpingoeca rosetta (strain ATCC 50818 / BSB-021).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Salpingoeca.
OX NCBI_TaxID=946362 {ECO:0000313|Proteomes:UP000007799};
RN [1] {ECO:0000313|Proteomes:UP000007799}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50818 {ECO:0000313|Proteomes:UP000007799};
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "Annotation of Salpingoeca rosetta.";
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL832964; EGD72770.1; -; Genomic_DNA.
DR RefSeq; XP_004994593.1; XM_004994536.1.
DR AlphaFoldDB; F2U8R2; -.
DR STRING; 946362.F2U8R2; -.
DR EnsemblProtists; EGD72770; EGD72770; PTSG_04500.
DR GeneID; 16075176; -.
DR KEGG; sre:PTSG_04500; -.
DR eggNOG; KOG3518; Eukaryota.
DR InParanoid; F2U8R2; -.
DR OMA; CKERENN; -.
DR OrthoDB; 5400510at2759; -.
DR Proteomes; UP000007799; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR PANTHER; PTHR45924; FI17866P1; 1.
DR PANTHER; PTHR45924:SF2; FI17866P1; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007799}.
FT DOMAIN 6..184
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 354..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 606..687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 471..603
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 606..623
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..661
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 663..677
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 687 AA; 77727 MW; 1C66DFFD02AFA253 CRC64;
MADAKKKLHA IQELVSTEEA YARDLRDIQR GYIDAIPDSL LSPEEKYAIF GNWKQLVTFH
EKFAVQLKTE FERSPQTIAR CFLGVNFIPL YTRPCCYHDR QLSILAHRQE SDSQLAALLH
TCQESLGHRL PLKDYLLTPV QRIMRYHLLL DEQVKRTGDE ETGKALLLEA HASMKDVARS
LNDRRRAVQV QDLMLGSVWL TRTKPLHERI VGLTVDFAEL GQLLAFIPEA NLLIEGKQGK
HSHRMVLCFR SGIISCKERE NNMLSVKAEY NLATCRLRLL DAHRFCVVIK DGGNDWDTYH
VANLDCKALL SDIYPSEADA SDGALSPNTR RHRILGNVLK PSSRDRVFST GKSKTNLMVP
DASPPKTPRV HLASDEGSAE SVVDDDASEP DVDTWMADLL VEQGSPSEFL SVQRILRSKL
MALDAKVKLL TQELQMAVAD KEHKDNDADP AHERHSVHFL HGALIAERLH VQELRSKLEE
REVQAKDAQQ RANEATRMLS AMQTTVEEQA AQVKSLLATI EDKDTQVKKL SQDVDAKTKK
IEQSQQACDH AQNQYRNTAH RFDTLQAAHE GLQREHEAVK KQAEEAQARL AVLEKKLLKQ
QAQFSAELDQ SHGSATAAGS DRRRHTFSLS GRRSRRSRRK RHEDQQQQQQ QQQQQQQRSA
AEHLVFEGEH GGDGASDPGE DARCLIM
//
