ID F2U960_SALR5 Unreviewed; 1419 AA.
AC F2U960;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=HYR domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PTSG_04976 {ECO:0000313|EMBL:EGD73263.1};
OS Salpingoeca rosetta (strain ATCC 50818 / BSB-021).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Salpingoeca.
OX NCBI_TaxID=946362 {ECO:0000313|Proteomes:UP000007799};
RN [1] {ECO:0000313|Proteomes:UP000007799}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50818 {ECO:0000313|Proteomes:UP000007799};
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "Annotation of Salpingoeca rosetta.";
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR EMBL; GL832965; EGD73263.1; -; Genomic_DNA.
DR RefSeq; XP_004994294.1; XM_004994237.1.
DR STRING; 946362.F2U960; -.
DR EnsemblProtists; EGD73263; EGD73263; PTSG_04976.
DR GeneID; 16074873; -.
DR KEGG; sre:PTSG_04976; -.
DR eggNOG; KOG1217; Eukaryota.
DR InParanoid; F2U960; -.
DR OMA; DADCANC; -.
DR OrthoDB; 2958415at2759; -.
DR Proteomes; UP000007799; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00185; TNFRSF; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 4.
DR InterPro; IPR032179; Cry22Aa_Ig-like.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR003410; HYR_dom.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR46967; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN,N-TERMINAL; 1.
DR PANTHER; PTHR46967:SF2; KERATIN-ASSOCIATED PROTEIN 16-1-LIKE; 1.
DR Pfam; PF16403; Bact_surface_Ig-like; 2.
DR Pfam; PF07699; Ephrin_rec_like; 1.
DR Pfam; PF00020; TNFR_c6; 2.
DR SMART; SM01411; Ephrin_rec_like; 4.
DR SMART; SM00208; TNFR; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS50825; HYR; 1.
DR PROSITE; PS00652; TNFR_NGFR_1; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007799};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1419
FT /note="HYR domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003290428"
FT TRANSMEM 1243..1269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 161..202
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 161..202
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 255..294
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 255..294
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT DOMAIN 295..385
FT /note="HYR"
FT /evidence="ECO:0000259|PROSITE:PS50825"
FT REGION 866..897
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 941..965
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1146..1178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1147..1166
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 184..202
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 273..286
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 276..294
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 1419 AA; 148819 MW; 27BA42E19A2F26BA CRC64;
MMWQVAAVLV VAVATTTLFP TARAFCWASC DVGEYCDFMS CRQCPPGRVQ PKNNHLDESC
DTCQSGKYQD RPGQATCKPW SKCDAGTFYR QGTNTLDTTC LPCLPGTYQN KLEHTDSTCE
TCPFGKYQNN FGQSGCKSWS SCGAGERWIV GLTVSDASCT DCSDGMFQDS TSHQSPTCRP
WQPCPEGKFV SSLPTITTDR VCMSCAAGSF SNDRNQDTCT VCPTGKFQDA AGQRGCNLCP
IGTYASQPRT IECRTCATGK YANETGLSKC KTCSSCPTGL SPSPACSPTT DTVCKDTTPP
VITARRPDSG SVIEGPAYVY TVVQHMKFQP PVVTATDTYS NATIVEPSYD SVSTAFVGST
QALAYTAMDE AGNQASISIT VNVIDDNAPQ LVFSPATLHL EAGLTPTAED YTRGVTVLAT
DAVLNSSRLV YDPASVSVQQ LGNYTVLYEL LWAEDSSAQS VRNVIVADTT KPDLRVDFGL
REVHAGNEVW HEAAITFVYP VVTASDSFDT TINSSSVISA EFPRFRPFVE DDTTFAFTYA
VSDASDNLAT VTYVVRVVDT MAPTVTITGD PSVTHEAGTE YVDAGATASD LLEDALERTI
DITTLNTVDV YPASVPAVFT VEYTACDKAG NCNNASRAVT VVDTQPPTIE LVGPSQLQVE
AGSELADIDP GAHVSDAYNA PSQLRLSIDD GGYAAQPASV PATFNITYTV SDTSNHTASI
TREITVIDTT PPDVRLNGAL DTVVGDGVGW VEPGIASAYD NADGDVRPRV EVRVVAQTVG
TAAAASSCVY SSARDFVPSV APRVWPSPAL DAVEASAPSG TVYRINYTVT DASDNVAHVE
RVVRVVDGSA PTMQLVGEQL VQLEFGGGSS SGGGDGEEGA GEDGSGAFAD PGVTAHDAHD
GDVSGNVCVN VSVVTANATG VLAVGSVADV AAYAVTHVVQ QQEKQEEQQD DDGDGGGGGG
GGEGGEGVVG LGGAVAWAEV GTVYVMQYSV QDRAGHAAAV VRRAVVVVDT TPPEVTLYGA
EEVHVPYATR YVEAGYSAQD VHDGNVTSRV VVRGADAIDV HVAGAYEIEY AVSDVNGNTG
VAVRTVVVDA LTRPDDDEDA VVELVLAGTA EVIFGGDVPQ LEADLEEALG VEFVVVFLVY
DSADGRPSDG SGNNDSVSSG SSVRKRREAP STPAAVPMTT ATEMTVVEFG VRDPGTLAWM
STTEVLTLLD GVVVLGTSAV LSASAYDPDL GTSTSSGGSN ASVSLTVIIA AAAGGVVFVA
MVVVVVSLLR RRSKRQQLAK TTLEAAQNPY QSVPHNGLET INPAFCGTDD FDTGKIAGEC
DCCHNSLEFS FILSLSFTVP CHLSFRCCRL VSGTSEHGAP LKVLQAQPAH TWDEADYDTT
FTSGYVDTGI LNMQPEYDVV TEGGVVEDNV YESAEDAVA
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