ID F2UAA3_SALR5 Unreviewed; 1149 AA.
AC F2UAA3;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EGD73678.1};
GN ORFNames=PTSG_05390 {ECO:0000313|EMBL:EGD73678.1};
OS Salpingoeca rosetta (strain ATCC 50818 / BSB-021).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Salpingoeca.
OX NCBI_TaxID=946362 {ECO:0000313|Proteomes:UP000007799};
RN [1] {ECO:0000313|Proteomes:UP000007799}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50818 {ECO:0000313|Proteomes:UP000007799};
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "Annotation of Salpingoeca rosetta.";
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL832966; EGD73678.1; -; Genomic_DNA.
DR RefSeq; XP_004993959.1; XM_004993902.1.
DR AlphaFoldDB; F2UAA3; -.
DR STRING; 946362.F2UAA3; -.
DR EnsemblProtists; EGD73678; EGD73678; PTSG_05390.
DR GeneID; 16074537; -.
DR KEGG; sre:PTSG_05390; -.
DR eggNOG; KOG2996; Eukaryota.
DR InParanoid; F2UAA3; -.
DR OMA; PYISRPT; -.
DR OrthoDB; 2911406at2759; -.
DR Proteomes; UP000007799; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00029; C1; 1.
DR CDD; cd21201; CH_VAV; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00173; SH2; 1.
DR CDD; cd00174; SH3; 2.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45818; PROTEIN VAV; 1.
DR PANTHER; PTHR45818:SF3; PROTEIN VAV; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF00018; SH3_1; 2.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 2.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007799};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 63..172
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 299..433
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 582..632
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 798..862
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 985..1075
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 1086..1147
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 921..981
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 738..756
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 772..791
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 942..956
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1149 AA; 126712 MW; 01F64F8D41780422 CRC64;
MDRGSDSSDT GSVRSSVGSL GQRPPMALPP MRQNNPHLHA HSRPSSLMGT QATEPPPPHP
GPAPTWREAA DYLCAAKVLP GLPSCPVELA SELRDGTRLC QLVQLLSQDQ RVDFNQQPRR
EFLCVDNIHR FLAYCSDVGM AKESLFEAED LFNGVHFERV VSTLSQLSTT PASIQQGLPR
FPADRRASVA VADDDDDDDD EDESVYENLS ELLEKLDSSQ PIDLIVPASP TTPPDGGASG
LAEDTASSLV VDHEADIYSS VVRSSHYGEL KRKAKQRSER RMCCYQELVE TERNFLECLH
ITDACYRQPL MTLLKENPAL APETGVCGSV FVEHRNDLLV YAEYCVDLPQ AKAIMKELTS
NKEVAAALKR MQLQSKQKFP LTDLLSVPMQ RVLRYPLLLK ELVKLTAAED PRLEALQSAL
STTQDVAKHV NECKHDIENY AIVQRLEHTL KDYVVGTSGC VPLVDHGRLL IDGDVKLRLE
SDGRAARRYI FLFQRVMLVC KAKNTGYHFF FSMNLKDFHI EPEWVKGAKI GVKLTTKVPS
AMAFNSTLIF KSPATRDKWE ELLRFAKAEC SLDAPKHPKG GTHYFLIHSF DKPHTCDQCN
LLLWGKFNQG LRCRYCHYAA HRQCSEMVDP TCKKSPQNQS IRDLLQRQKQ PAPDNSDGRE
VEPSIRRRLA TADKAAQQQQ QHRFSGAAVH EGSATRVQGS GSGDTSKHDG DVGVGGGGGG
GNEDDDIRPP PLKPRASSGE WQTPTTTANS DATPLFSKHH PSHVHVGGGA ETQPRSPSSS
YTPSDPLTAS PAQQEEAAIG DRMYAVHTFH NRRDSRRGDL DFKRGDYIVL LDKSSPHWWK
GRHERTGQIG MFPVSFCKSV RPHEPAPSAV PPKLSTAAAR ASTTASAGVF SNVPARTSSQ
LMTKGPVVDP LASQRVTAVK RLQSRPTHGD TEAPPVPPKS ERVQLQMQSS SPSAEQCDDC
AAPPSQPSTG SPPPLAARQQ PSTQWFVGEM SRADAEEHLL LARDGSFVVR QSANADNSFV
ISLKHKGIVR HLRIVASERG FLLGASKTFP TIPELIKHFQ RESLEVHFPD IDMPLLFACG
TRAFSASSPR YAATYSFSAQ AKDELSFEEG DVVEILKKTG FGKGWWLGRT RHGEGLVPSN
YLEPMDSHC
//
