ID F2UFK7_SALR5 Unreviewed; 809 AA.
AC F2UFK7;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Sodium/calcium exchanger membrane region domain-containing protein {ECO:0000259|Pfam:PF01699};
GN ORFNames=PTSG_06644 {ECO:0000313|EMBL:EGD75575.1};
OS Salpingoeca rosetta (strain ATCC 50818 / BSB-021).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Salpingoeca.
OX NCBI_TaxID=946362 {ECO:0000313|Proteomes:UP000007799};
RN [1] {ECO:0000313|Proteomes:UP000007799}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50818 {ECO:0000313|Proteomes:UP000007799};
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "Annotation of Salpingoeca rosetta.";
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; GL832972; EGD75575.1; -; Genomic_DNA.
DR RefSeq; XP_004992032.1; XM_004991975.1.
DR AlphaFoldDB; F2UFK7; -.
DR STRING; 946362.F2UFK7; -.
DR EnsemblProtists; EGD75575; EGD75575; PTSG_06644.
DR GeneID; 16072591; -.
DR KEGG; sre:PTSG_06644; -.
DR eggNOG; KOG2399; Eukaryota.
DR InParanoid; F2UFK7; -.
DR OMA; IYLWQAV; -.
DR OrthoDB; 5482417at2759; -.
DR Proteomes; UP000007799; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR PANTHER; PTHR12266:SF0; MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN; 1.
DR PANTHER; PTHR12266; NA+/CA2+ K+ INDEPENDENT EXCHANGER; 1.
DR Pfam; PF01699; Na_Ca_ex; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007799};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 227..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 298..324
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 356..380
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 557..576
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 588..607
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 614..633
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 645..663
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 714..740
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 761..781
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 787..806
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 232..374
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT DOMAIN 650..799
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 386..415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 455..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..472
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 809 AA; 87869 MW; 938E2D83D87A9917 CRC64;
MMSHDSAVAP PTPTADAFGG PCRDHSTMGS ARRRSREGAG CPVCRMAATQ SQISSGCAPD
SRGRRRIRHS NTNRTCGAQL EGNVVNAARD PDVDGDESPL AMKSWPSSTA QKHCRKHRLE
RASRKALGYC VVFACVFVGL LVLSTVTNRV QQGQSTARVA RSLDNGTLSL WLTDDIPPAL
ENATCGNFHA HNDTCYFVKH APDCAVDGGF INYLELPYCI FNTEPPAIVL LLLWLVFLFI
ALGVTAEDYF CPALSVISDT LKLSHNVAGV TFLAFGNGAP DIFSVYSSIN NAKNGVQLAV
GALFGAGTFV TTVVVGTVSF YYPFALTRRP FLRDVSTYLI ATTWTYVVLW RQEITTAQAI
GFCAVYIVYV LVVIVGRHIY QSRKKRRMDP IAEKKREARK EELREHPQHG SHRHPHSLAE
AFDVAESIGI VAALGHDIQA SHHTGATARV GMNGHEHARA RAHERSGGSG DESDDDEMLD
ARIVETDSDV EHTAVTAAVV AAGGVREDEL TGYGDEEPLL SSRTDLEPPP PAWTQFFRAI
VPFTKDDFME ASIIGKAYIV LSIPVTIALT ITTPVVDFDE EDERWVQYLT MLQCVVAPVF
GIFGTGFGDV TIGGVYPVWL LGMMVGGVIA LVIWTTTRAS RPPRFHAVFG FVGFLVAVIW
IYIVANEIVN LLQTLGRMFG ISDAILGLTV LAWGNSIGDF VSNMTVARQG YPRMAVGAAF
GGPALNMLLG IGISCTIACL RNDGHFPVKD QPSHQLAVSG GFLLLSLLSS MVIIPLCRFH
ASRKYGVYLW VLYLCYLASA LALEFTGPS
//
