ID F2UGL5_SALR5 Unreviewed; 5898 AA.
AC F2UGL5;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN ORFNames=PTSG_07883 {ECO:0000313|EMBL:EGD75765.1};
OS Salpingoeca rosetta (strain ATCC 50818 / BSB-021).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Salpingoeca.
OX NCBI_TaxID=946362 {ECO:0000313|Proteomes:UP000007799};
RN [1] {ECO:0000313|Proteomes:UP000007799}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50818 {ECO:0000313|Proteomes:UP000007799};
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "Annotation of Salpingoeca rosetta.";
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL832973; EGD75765.1; -; Genomic_DNA.
DR RefSeq; XP_004991686.1; XM_004991629.1.
DR STRING; 946362.F2UGL5; -.
DR EnsemblProtists; EGD75765; EGD75765; PTSG_07883.
DR GeneID; 16072247; -.
DR KEGG; sre:PTSG_07883; -.
DR eggNOG; KOG0190; Eukaryota.
DR InParanoid; F2UGL5; -.
DR OMA; CTINIRT; -.
DR OrthoDB; 161058at2759; -.
DR Proteomes; UP000007799; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR CDD; cd00051; EFh; 1.
DR CDD; cd02995; PDI_a_PDI_a'_C; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR022099; DUF3638.
DR InterPro; IPR022105; DUF3645.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR017937; Thioredoxin_CS.
DR InterPro; IPR013766; Thioredoxin_domain.
DR InterPro; IPR001876; Znf_RanBP2.
DR PANTHER; PTHR13367:SF35; RANBP2-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR13367; UBIQUITIN THIOESTERASE; 1.
DR Pfam; PF12340; DUF3638; 1.
DR Pfam; PF12359; DUF3645; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF00085; Thioredoxin; 1.
DR SMART; SM00248; ANK; 4.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS00194; THIOREDOXIN_1; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
DR PROSITE; PS01358; ZF_RANBP2_1; 1.
DR PROSITE; PS50199; ZF_RANBP2_2; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Isomerase {ECO:0000313|EMBL:EGD75765.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007799};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00322};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00322}.
FT DOMAIN 4294..4329
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 4330..4365
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 4817..4846
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 4844..4970
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
FT REPEAT 5245..5277
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 55..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 201..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1448..1486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1662..1704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2537..2596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3635..3741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3815..3839
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4000..4026
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4063..4096
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4403..4427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4467..4493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4588..4651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5118..5137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5375..5397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..237
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..252
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1462..1486
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1687..1704
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2568..2591
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3641..3667
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3718..3736
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4000..4018
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4068..4086
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4403..4417
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4594..4620
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5118..5136
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5898 AA; 652473 MW; DED596DBDA07558B CRC64;
MEPQEQQQEQ QPTAGAAPSL QETIDLLTAE LNQWKEKAGA LEDQCATLQA KVTQLQFESD
NEDDDDDEAE QQQKMEQAAT LAQMCPDVVM DTKTRFFDFR YSVLPKNLTS VGDSNVRLDT
SSKGASCVTI PPKTYLKVDT GYADDEEARI SQYTIVLDIK VDLSKMDQPV ALYQACYPDQ
KEHKTVQAYL LPTGQVVTKL PKEKKKKDKE KKEGNEGDED DEDEDDEDKE EEEEEEEDAA
NKRRKKKQEP PALVRSNRWQ RVTLTVRPGA VSAFVEGRIS SKDTDVYRNI KQAWAMDPRG
FLLFAANKPE HMPGGVSLRL AQVISQAWGD EEVKQKNSNH KAVDIRGMRM AADMHKMMSK
LVLAPLKLTP KPVPFFRDTN LIAEFGDPFV ENTGYEWGQA YSAARVYLLT LKRMRSEEVN
VLSHLGFGQS HFDCLQRLQA SIEASLPLYK KMHMLQKNND ASGGLARFLK ALSKQFLAMT
PGDFLLVPAV VVNETDGDPF GPAWKAYGKQ CETIITTAPT ISVTKSLTLD YFRDLHIGDH
NEIWSFEKDS YRMTPEQSTL KFTHLIGSPL GCTINIRTIT GEDPTVTRIW PEYVPYRDIN
YWFKYFLCPH NELMPMRPGN YTTPRGRLNW RYEASENALI VGAHGVQDFM ENVRYSGGLR
GSNHRWPSSA NPMSFTKPHD ARTEDDVLHV QTMPDFDGQL GQRDSELLIS FLTVPYIRIP
LVLNFFATED RIHTLQHQQL VDLLNSVVFE PGRYIPSAVS DELRMPTEVP TLIADQLASP
YSAIINEVVH SPAQLRDVAV KLLKLALSLD TGSAFATTQP VATAVVLLVA RIETVFSFVY
HTTLPIPNLQ VSPENRATIG DACQQLQALL RGNPDNPTAM SARHMFHMWV EEIEGKMPGL
SAFGSTSSSA GGAPSADDRQ RANQLTNYTD LACTLHAHIL WLYRGLPAEG MTFDSCATIL
RSFIYLSIKK TWNTSGKPAI PDTEVFEIMH TLRSGLVSFL NRYLGAGVPS SDRARFAATL
QQAYEHCIGA SGTASELDQV WCAVEGEVNR GRYVTSRHPT IRDVAQTRVP TVKEGVYAVE
IDLQTLELRM RGTSLRALDS EIANNGDIQF LFGEQARMIQ CTVEGTYENK RSRFLVGLGY
QLDFWTDDSK LKPMYETYDR EYDPGELFQS EEWIAEVFEP VRRAWFCRPA AREDVPFFLP
EEEFPHDTSV ALLVGSHPQF GRDWFEVLVF KAYRMCHAYL VTSHGRRYYR TLVYATDARM
SLRDMQPSTE DRKQPWPIVN TPRGAWQWGR HEAFDKSFPD YVANLYPPPH PASCVVQRPL
ADPTLSDSEE HAAEVKLVDT LMAPLSTALR DLLEVFSEVE TSTRRTYAVP EQLLGGAAAA
YAELDKLLST TEKHEYFREL DDEDEDDTSL RGMRAGPAQR SALVQLQSVQ RAAREIIKTV
QAVHKTMREK EEAASAAEAG DVVDDLGDDD LGMEQEEEED EDEDEDAYAI YKEPWDDLRP
HDHYFYEKNE WYLTRRIEEH GMECSECEEA IPAKSVCYYD MTEGCALCSQ CVGKEPPYYV
VMDHAKELRK HAYDAQRLCE ADVAKQETYI PPRLLYGMIP SALLEKYDFW QDPDDRLRGY
PRNTAPTQAT NLIYVTFSKL TRQPELGLPG VSATITKRCI VPETEQQHDD NGEEEGKEEE
VGDSGQGATA AATTTTQTTK AKKNKAVATA SAEEEDLIYF NPLFAPSDGP VGSLIRILSR
VENLSHVLFW GRASKPGLDL YRIELPRLGL TFQERVGGDG VRRMYSLDHA SLFLPMVAPG
GHVQQLLRGI PHSICLVTEN GEMSVLVPNV RVVRPVIAAA PFSTELVLDR LTEDGEKWAE
NANVAYFMYP LHVSSCFLEC TSLTSALYLL LLRFFHRDHD DVAQLSFAIA TDAALSVEQA
QIFDLLELAS NDFHPDAHAN RVKIALATAD SPIVCPFNVA LEAGRYLTKL YHVSARCRLS
TQEELTALDM CEVIEKKLSI ANSVAETFDE SALSKILRFL TSEKEAEFAS AQEMRDADRC
VKLMVDQVRG QMGVAIQKEE AVRLLQSAAE GDGLPAVMAA VYKNRKSFLE ARRNNHAEVA
CTVPEPVAVG EWVSHSDKVV LTVTRQTWKD VSVQYNSQPS MSSIACVEKA LEFFSRHESF
SGSRCRSGFL FLFEALTGTL KVKLRGSKPH LFVQNVMRLM EDHVTGGLLG SIIHVLANNP
DLCSEASIRW KDTRNIKSTY IRARGSFLEP ANPLSDLFHN VTTLIKAKEE ANELHWPAPL
KSFRKLPKVP TKLALSSILA TLPSFVHTQG GLDTASGASG TDATATLKAC MDTDSPPTYV
VADYMRSKLN VLQAPTAIGG TGAPSGGTAA TARVQQILAS ETPEALQALC EDLLAPADAD
AFISRVSRDS VKGCLPFDAT QHPHAAASIS KTTLTRLEHH MQAFAEAYNN STVPYITCVK
NLIAALGPDA TKAPSSATGI TAAADEAKNT LDGLLLALQS LKKQDNEYID RAVDAVTAFA
NEVAVGDLAS VALPEVKQTS TDKASADDDN DNDSNADADA SAVPAGHDNA DAQQQQQEQQ
GEQSAAPTAA TAATAPVSED EHHRLLYLLL VAGRQRAPLW FEYIISQLLT TKGVEDLQKL
NPFLSDGDCI AIEQITLRIL LRSTRVGLVN RCLELCRDVS KLCTRLVKAA ATAVAASPDV
AGGATDAVAA VSRLESVRSE IEMKSINLAT FLTTKRQYSG LQPTDDAGAI AGAGASAAVT
TVDPRLAVFE FKSNIVLRER QVQLVNKFMR AIQEERRDAV EQMLMGAGKT TVVTPLMCLM
LADTTQLVSL VVPSALLEFS RSVLRSTFSS IMYKRVYTLN FERGTAIDSG LLSKLQHARS
SGAIVVSTPS AVKSVMLKHL ENILVVNDPG EKDRQELQRE VRTAPRLLEL WREGVCLIDE
VDVVLHPLKS ELNFPIGRKE DLDFAPLRWH LPMHIVDAVL AVSQGVSPQT TGHKAQAVLD
KLRRVVREGY EQCFLQRQPH LVLLNLGFYH RKMKPILAEW VGLWLAQQGL DMIAHGDAVQ
QFVGGDRYGP ADRINALPEK RFIKMVNLAH DWLASFLPHC LQKINRVSFG VMLPSDIQKF
EDMSTRMPQS RRLLAVPFVG KDAPSTASEF AHPDVTIGLT ILGYRYQGLR TSDFNDILQN
LQSQFTREMG PKDQRFSSLR YAAWIKAAGG LVCGSYQELK DNDTAAEVVL PKAVAVRASH
RYWIDQAGVV RSCPAVFFSE DAIQPDAGSS PPGTVVVTKL PNLQRKPGFR YAVNEDGDVV
ASRVKVVPLH LLRRSDDMQV KPLYALLREQ PAVIHAYLEE TIFPEHMRHK RFKLSASGQE
LGGKMLFGRT IGFSGTPSDL LPEDLGRCNF AQEEEGEIVH TLTRPDVVSC SFVKEKQWSV
HRLLQEIASS TQPYFNALID TGALITGMSN AEVARFLLAN GLSQRGIEGV VFLDDRDRKM
VLIAATNRVV RLSECGIDKD KRFAFYDQVH TTGTDIKHIQ TATAALTLGK DMTLRDYAQG
AYRMRAIGKG QKINVFITPE VQELIESHMA KGALDQATAA ALPWRVKVIG WLVINALFTE
MIQHNLLQLQ NAANVWRKSA FRALMDHENR LCSLEGVETA EPDQAGKKGA EGDTTSAEDK
DESQQQEDGS KAVAASDDAS KTQEDVQEQE QAADADAGAD ADAGADNAGG ETGGEPEHSD
SSEDEEDEEE EEERDAELDE TNRKLVSALN VFREFMDFSL QNAVVPPVDL HELVETQMEA
RREFITSATA ETQLTKVLDR LSAPLQENIM RQKSYEAPQV NQLDQEQEQE QEQEQEQEQE
IEIEKFVDLA YSRTNEAPVP WELEELLEYP PREEVFYPAS SFSLCRRPSL DMPDFLYMSN
NYFNKHWTGW RRIKNVNVSM ECIPDDSDAP DAACTLPMSP QLRASAVSAL SQMWRLFDSS
AATTTIPMPA PETTTPQQAQ QAQQGQGAVC DAETGVCTTT TPTSTTTTAT SAATASITGG
SDAPAEAEQT ATMVVVSDDS SMPASQLRDL MFACVSPSAR TADIEGTVGE DSDTTSSSSS
SSKRKGSGVA GEGAGAGSSD DYALHALIDD MVATLTGGKP ETPVSFKQFR TLLLGPAMRA
VHNKRYTTVL SLAEAETMRR ILHLKQHASK GALLPGSHCS VALRLPLSGD LILDQSVGHS
PQPTFQQQVI LQTLKFFDCS MYYTSTQLRS LLSAIQSNGL VERQVFFENV LSCRRRANQK
WQDTPLAKAL GVQTEFDMML SSAATLVVGS TLASKGLLVQ EAFELFDRNK DHYLDADEVY
GMLTWLGFHP TVDEVLNFIE VTDQDGDGRV SYHEFVRGVQ QVRERVALSP AARVALFRDP
QTIEVPTAVV QDLQQAAAER RRKATRHAAE LEKRKKQQLN AQPSMGAGEA SEALIKGDDM
LVYSLEYGKM PPGMQCINGS GDFNITSEGR RLRRGAGGRR KRRQQTKGGK EAEPQAIYNF
TLPKQVFLRM PVPRSSGSKL REYTITLQLR PRTRPSFAAG LISLPFVKAN GDIGYLGVMQ
DSSGRIALLE GKGSKLQPLD PLPRANLHVA PAADAQDDRT KVKKNKKGHE DEKEEQKTQD
KQQGAQAVAK KGDGEATKEG GGEGAESADA SDAAASAASA AAEREAAVLQ DVFKLAPDTF
ASYYRKNEGI SEAQAVLGYF PMFAGDDDEK EETRNTESVL YNWNMHTITI AVSGTTGHVL
VYVDGRPIGV SQVEPGRLSL RPYLTLRGRP AKTSEKRMVT LMGHALDDSF SAGGDVVKCR
FDTRILSEDE VRQEHVQDGC WRCTECATYN RVGAYRCMFC DSYRKRSAKP PLNNADPDHP
GLTIVVTDTF KQLVLDKTKH VFLDVYADWC GPCRQMAPAW AQLAKLLAHR SDVVIAKMDS
DLNVVDRSLL PERSIPNLKL FPMSDKHSPI RYEGPRDVPS FLAFLQKHIG LDVENVLETS
YQAYKEEHNV QQLLDRIAAA MRTFNPPHSV HFLQMYFTDP DVYDAAVDAD AVRERPVAGL
DMVLETVERC IKQQQSGDDM RMLHNVFTLT GGHHQDHQAS EFGFEKLDLT GVEAMSHQAV
QVAWGRIVKA FAVGKHLDDD DEDEDEEDAE VDADEDVDAS AVAKKKMKKN QGKKQAVPAT
VGDASAAVAE ALGGSAMVGQ LQRKADRDVC SLFSSTQVYE NGDTLELTPR QRLDKFKALP
KVTQHRLRLM AELVRQGYPL DAQPYGMGAI HLACLANDLA LVDFLFTNGC NLQAQSRALR
GLAPLAVAGY FGHEALAVYL LKMHVCIDKA LYMSVLGRQP RLLDLMLRML GDGPHANVRL
EGATLLDAAL ATDQPELAQH IRSLGGLRAR DVRKRLQKKK GDGEDAGAPA TAAATTPSVA
AAQEVAEEEQ TAAAASLDGA VMTQMEMLYG EMRSLDATYT KLREQGASST TKDGLGVSLL
DIACLYDSTA LLERVENEEN LDVAAAISAH HLPLMVEANV SSAHAVLAHL KQAGILESAR
DEQSMEFMRT YLSDALASQR TLLTTPATGD VRSWTIYPSS AFSDTGRYVG MPLMVSNIIP
CSSPGASGIQ LQDIKPSSTL LEFVQDLSSV QLSLPQPEET PPVLARSVSG GAALLRQLSS
SDPSSFFADC LEMDMTIAMN NVLFDSWNQL LEAARLLRVA ATWRSAVLTP SQAMALFMIN
HDTGLTRLCQ KALRLYARRQ DELSRAIVSA VSVMLHEVQS ALDTLPPMRG SVVYRVCAVP
DIKRFFRIYR EQRTVFWPGF EWATASPAVV YRLVGILRQR FPTYHIAVLK IHTSNARDVT
TFAPYGNQLH TAMFPIDTSV VVTGYYKFSN FALEAGTSHL HPSLHNIEEF AGKPMKKGAV
IDAKEPKTFV VTVNERAN
//
