ID F2UGT4_SALR5 Unreviewed; 3252 AA.
AC F2UGT4;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE RecName: Full=UBZ4-type domain-containing protein {ECO:0000259|PROSITE:PS51908};
GN ORFNames=PTSG_07952 {ECO:0000313|EMBL:EGD75834.1};
OS Salpingoeca rosetta (strain ATCC 50818 / BSB-021).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Salpingoeca.
OX NCBI_TaxID=946362 {ECO:0000313|Proteomes:UP000007799};
RN [1] {ECO:0000313|Proteomes:UP000007799}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50818 {ECO:0000313|Proteomes:UP000007799};
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "Annotation of Salpingoeca rosetta.";
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL832973; EGD75834.1; -; Genomic_DNA.
DR RefSeq; XP_004991755.1; XM_004991698.1.
DR STRING; 946362.F2UGT4; -.
DR EnsemblProtists; EGD75834; EGD75834; PTSG_07952.
DR GeneID; 16072315; -.
DR KEGG; sre:PTSG_07952; -.
DR eggNOG; KOG4751; Eukaryota.
DR InParanoid; F2UGT4; -.
DR OrthoDB; 5491775at2759; -.
DR Proteomes; UP000007799; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 3.
DR InterPro; IPR015525; BRCA2.
DR InterPro; IPR015187; BRCA2_OB_1.
DR InterPro; IPR015188; BRCA2_OB_3.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR006642; Rad18_UBZ4.
DR PANTHER; PTHR11289:SF0; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN; 1.
DR PANTHER; PTHR11289; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2; 1.
DR Pfam; PF09103; BRCA-2_OB1; 1.
DR Pfam; PF09104; BRCA-2_OB3; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 2.
DR PROSITE; PS51908; ZF_UBZ4; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PROSITE-
KW ProRule:PRU01256};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|PROSITE-
KW ProRule:PRU01256}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007799};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU01256}.
FT DOMAIN 2717..2745
FT /note="UBZ4-type"
FT /evidence="ECO:0000259|PROSITE:PS51908"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 89..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 552..726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 745..857
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 950..973
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1007..1028
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1060..1287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1415..1451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1573..1642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1888..1992
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2106..2154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2284..2428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2468..2721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2742..3054
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..155
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..279
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..307
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..322
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..385
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..437
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 555..574
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 575..602
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..631
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..655
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 696..710
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 745..765
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 950..968
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1060..1083
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1183..1225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1226..1240
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1250..1272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1433..1451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1583..1642
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1896..1918
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1919..1933
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1956..1977
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2133..2154
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2289..2303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2346..2363
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2401..2419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2524..2538
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2557..2573
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2574..2608
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2618..2668
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2669..2692
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2693..2708
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2786..2800
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2805..2828
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2841..2855
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2863..2886
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2901..2917
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2918..2944
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2945..2960
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2975..2995
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3006..3032
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3037..3054
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3252 AA; 344737 MW; 9EBF1E24B74176A6 CRC64;
MGRQLPPGFS CCLIGPSTPQ YRATEELGGE GEGGGGGDGG DGNVRGVVET SHGGDGVGSS
DLRARQAAVV RLISTYPPTM RVHMHTLWPN DADPALSSTS TPDKHAHTQQ HEQQQEEEEE
KDDNDGNKGD HADDGDDDDD ADDDAGGDAG DDDDDTPATA TPSSPTSPVA SHRHNADSPQ
GREAPSAARR DSAAGLAGTQ WLSPTQQSLI NLSNQKNTQT LFDDSQWRSG QQTQLSSVPS
PWMPNTVVTQ PRHANDTGDS HDDTSDDDED SDTEEAGNDT ADAGNEHARQ HQEAGAPTQT
QSLQDTAATN DDDDDDDDDD TQDPRQLTGY SPTQLVSPTQ LVSPTQVVSP TQIVSPTQLC
GSPTQPVTPS GATTKPSTSG ALRCDESPAT QLAAPTDGVK MEEVVEEVVE EEVGEGKADV
SEQAEGAEGA EELKGSKGEV KEEVEYMHAG EHDERAHERD ESRTKDCTAP LHPKLYSPHL
ARCLLTSTLT RAPVSPRAPA AIAPATPATA STATMASAVD VSTRGILMKT ESLDDSVNSA
TVALDAPLNW TDEFETPCKG KKRQQQESGR HCHRQQRITS TPTLPAFNDT SPASSSAATT
AHPSPLRVCV GTDSNVSSTG ASATKQKRAS PPSRPLFTPP LKQQPLNQAR VSPSSAHTLA
HGGRRGDGVK RRFVFTTASG KTVTPGTPTP PHTSTPAPLH TTTGESGSGN ARQRGGGVES
GGSGSGMSIS AAALQYAQRF LLSHQQPDDD GKGDDADDQQ HQPQHNKQHN KQQHQHQHQQ
PPLPLLGDDG DDTLHLQKHN GTDKSPSMSC VIPVHPPATA EEESGVKPCT TAAAKQRSPR
RDEDASTKPT GAAPAMMGFM TAGNKSISIS DEARRKGEAL VNAAMNEAAT ALNKDDHNDD
NTNNVSSGGG GGGFGGFMTA GNKSISISDE ARRKGEALVN AAMNEAATAL NNDDNDHNVS
SNTSSGGGGG GFGGFMTAGN KSISISDEAR RKGEALVNAA MNEAATALNK DDHNDDNTNN
VSSGGGGGGF GGFMTAGNKS ISISDEARRK GEALVNTAMN ESLSDTTTPS SSASASSASL
SATSEHPPPP PTKANAGFVT PRSTAHMSRR PPSATAGRAM STGRVSRIRI GRGGRGRGRG
FGSAPHSAPR SAAARMGIPE SFVRPFKAPR TKRRFSSPLK LPRSKQPGAN NNNNDNSSIS
GSSSSRGSTH ARRQLGTGAS PATAPSPSSP SSPMLPSSRR PAIPPFKMSP STSPHASPAA
LKDRTNTGSR AGANVADGDG EDGDDGGVCR GLDAAEQAWH ALLGAHHKDG SATDDESVLD
LNWTDALRMQ DAAAFIQSSL LSERRGNNHN DNDNRGGDST CCDDPSWMLK APLSAIPVIP
PPSQRYTTTT TTGTAAASSA CVTCYGVTVW RPTSVTPHAD TNAGDAQHRE HQGSLKQQQQ
QQQQQQQQRA KAGSHLSFTL QSILDALLRD TGFVAAGVVT RKWLALRLRL VWWRECARLL
SSKQPHATET PTTAALAAEE GAVRRIVEWV LCCVHFEYSL GKRSTIRRCV EGDDVAGKPM
VLMVRCVPVV AGTGRDPRAD ASAPPSTTHT RTPSPQFGQS KPVTTNDDNT SNKDQRGNTK
TRQTTTTTSS ITSAGENSRS KAETWDVLLT DGWYDIAARV DDALRARLQR EEIVVGDKLV
VFGAALKSPN PNHPLDTDMD MTYITIASNS TRVIADHGVA LGHKPLEYAP VLAADDVDVR
GGAIACMDLV VERVFPVLFL STGEGGARSI CNERVQARRN VQLDEERRRA MANAAQEALG
NACVPAHAKR HFTAEEVAAL TTGEELQQCI QQSKDAEFTQ RLFTTHQRQL LQGYRQQQME
AVARRVNEQG GRPVSMVKIR AVDVSRLAGT RMAPEKQRGG DGKDGKDGKA SSHDDGDGGG
VGEEDDDDDD DGQEATEKAR AGSGGVDAVD NSDGPATEAS DDDEDDGDDD DDNNNRDDDE
QPSQAWPPKT KLPASDLLER IAGADHSDLP RCWITVWRTS EPEPVKEGDH VRVYGLTPHH
RRTSARLELN ANTRTVFDPQ PKLRGRTGLE RAPAEYAHVA AMPIGFEVDV CGVVVKVDEP
GLRSPRTMQK KTVSRTGHAT AAVGAAGSGS GGDYGASTAT PGTSNPQQQQ QQHEQQVFIC
DADANMLMVI IRGSVADYTG SAALRPGQPV CFMNAVVIPQ SSKLKWPTCV LTEISTISSN
PRARALSTAL RHLQQAVKEE DLLATAQEYV DKCWTNPQLL VERSPTTPAA AGAVVGGVRS
RYHAPPSPIL SRQPTSTLCG SSGTGGEDEL DPLAILTSDA PIPERPVPEG IRSSAKTRRP
FKLPNAKASP SSSPSSSSTS PMPRGRGRGR GRGLVSPSGV GRSPGKHITY GSPLHRKQRT
HAPSPGNSSS SSSSSLARRG VFVSPRKLSM PTSACVLGPA AVARDEAGCR IVVCGDGSMR
VDLRGLVKQQ HSGDKKNGHD IQQQTGTKAG GKPEATHTVC AAGLQAPRKE AGSEVKQDRP
CDVDDADGDG DGDGDGDGDN DTAQSQLYCT QLGEDTLRFI EEAEEAMEQE QAKEVVEEVE
EEVEQEEGGE EEEEEGGEEE EEGEDEEGKE VRTTEGISHA DETSTTAGAS TPQPSSKNKA
APPLSPTSIL TQHLLGNAIT QAHQQQQEEQ DEQQQRQEQQ EQQNEADRGH DQRVQPSTSQ
QDTVNDTTAD APDGGVDLHC PICGEEFSLM EDLIEHCDSC ADTQQLRSGR RLRVASQTPR
SRRRSKRRST TTTTGNDDDN DDNDTGAAVT DNNQQEPPAN IGKSKRKPRG GRRGRRRKSG
RRSTGRRSVK RTGAGEEEQA VTQEVKQEVK QMEDRGGEGG GGGQMQQQRQ HQHGYSNNSS
SPAKRAKCTS DGDDTKRTQQ QQADARANVS GIDETQTEGD GDTAEEAGGG EDSMQTEDDT
EQDTEGIGTQ QLVTQTTRVD DDTCDAGDGK GGENDGESTQ ASQSTVNNDT PLSLPVQAGG
EQVGKGGQKE TRRVGDNAEG ARDQKRAKLT AATASDDDGN DDSDDDGNDD EEDEGQVVGD
ACYVHGTVGA VTAEQLSGTL RPRHPVALWA ALRRGGGGGG GTHCDGGGGT VQVPETCVRA
FLRRCSKATP TQVKGAHAWF VRLKHRGQCG ANQPGTRAAS LSRQRQDALR GPAVNCEDII
LECLRRATCV DRSQCAVCSA VSRLYGGTVA PFTEAEWRVF SYRLRLLICG HPITATLDTT
TDPTTLQLPP LN
//
