ID F2UHW3_SALR5 Unreviewed; 343 AA.
AC F2UHW3;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=NAD-dependent epimerase/dehydratase domain-containing protein {ECO:0000259|Pfam:PF01370};
GN ORFNames=PTSG_12676 {ECO:0000313|EMBL:EGD76712.1};
OS Salpingoeca rosetta (strain ATCC 50818 / BSB-021).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Salpingoeca.
OX NCBI_TaxID=946362 {ECO:0000313|Proteomes:UP000007799};
RN [1] {ECO:0000313|Proteomes:UP000007799}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50818 {ECO:0000313|Proteomes:UP000007799};
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "Annotation of Salpingoeca rosetta.";
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. Dihydroflavonol-4-reductase subfamily.
CC {ECO:0000256|ARBA:ARBA00023445}.
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DR EMBL; GL832975; EGD76712.1; -; Genomic_DNA.
DR RefSeq; XP_004991084.1; XM_004991027.1.
DR AlphaFoldDB; F2UHW3; -.
DR STRING; 946362.F2UHW3; -.
DR EnsemblProtists; EGD76712; EGD76712; PTSG_12676.
DR GeneID; 16071646; -.
DR KEGG; sre:PTSG_12676; -.
DR eggNOG; KOG1502; Eukaryota.
DR InParanoid; F2UHW3; -.
DR OMA; GNRHILC; -.
DR OrthoDB; 1694166at2759; -.
DR Proteomes; UP000007799; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd05227; AR_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10366:SF564; 3BETA_HSD DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR10366; NAD DEPENDENT EPIMERASE/DEHYDRATASE; 1.
DR Pfam; PF01370; Epimerase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000007799}.
FT DOMAIN 5..244
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
SQ SEQUENCE 343 AA; 37746 MW; 9E27FBE184F2D427 CRC64;
MAERVCVTGA SGYIATHIVQ QLLEAGYHVR GTVRDPSNEA KTKVLMAIAE KAQAADRLEL
VKADLLDEGS FDEAVKGCKY VLHTASPFQL QARGSPEEYF VIPAVKGTEN VLNAVAKADS
VERVVLTSSC AAVEGYADDK DTPFTEDDWN RTSTLSDGAY SLSKRRAEEA AWKMAEQQDK
YTLVTINPAF VMGPTLTGRN DTASVEFLKV RLVVGVDGVD THCLVDVRDV ALAHIKAMTS
PKAQGRYICS AKSMSVLEIA AAISAKYPNY RVPTRKVPKF LLYLFGPFQG LSWSFISHNV
GVPLEFDNSK IKRDLDFEFR DVDTSLVEMV DSMVQHGLIP DRR
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