ID F2UID0_SALR5 Unreviewed; 716 AA.
AC F2UID0;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 28-JUN-2023, entry version 34.
DE RecName: Full=VWFA domain-containing protein {ECO:0000259|PROSITE:PS50234};
GN ORFNames=PTSG_08226 {ECO:0000313|EMBL:EGD76879.1};
OS Salpingoeca rosetta (strain ATCC 50818 / BSB-021).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Salpingoeca.
OX NCBI_TaxID=946362 {ECO:0000313|Proteomes:UP000007799};
RN [1] {ECO:0000313|Proteomes:UP000007799}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50818 {ECO:0000313|Proteomes:UP000007799};
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "Annotation of Salpingoeca rosetta.";
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL832975; EGD76879.1; -; Genomic_DNA.
DR RefSeq; XP_004991251.1; XM_004991194.1.
DR AlphaFoldDB; F2UID0; -.
DR EnsemblProtists; EGD76879; EGD76879; PTSG_08226.
DR GeneID; 16071812; -.
DR KEGG; sre:PTSG_08226; -.
DR InParanoid; F2UID0; -.
DR OrthoDB; 3816176at2759; -.
DR Proteomes; UP000007799; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007799};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..716
FT /note="VWFA domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003290692"
FT TRANSMEM 572..593
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 59..212
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 598..716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..634
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 659..688
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 716 AA; 78610 MW; 1D8FDB0AA3C4CE28 CRC64;
MIGTRNGLLA VSVIAVALLS MLWSNKQYSS SFGGNIDDLD DFHLLLTEAQ KKVQSTAANV
LFLVDSSGSI SADEFDKEIE FCRQFMQKVN TKGAVSLFAS QTKFVTQGFV NRIPSNVERI
SGSTDLAEGV KESLEHYVGN NAPVVLLILT DGQADDIDEA VEVLDNKAHN VVLRVVVGFG
QAKHDYLQRI AAGGLTFRGA DIHQIIDMLE KENQNPIKLQ LLNFRGSFTS GTDLSTMTYS
GTLRNADQLR PTTPDLFLEL SESDETDFLK GGFFFKLPKV LQPGESITVT FDVPVRNPAR
GEISFAQVPS IFAPYFASLQ FYDYKPRFIT LVGPVRNGKT TFTDIYCYGA KSSRSRNLDV
CGNGTTESCT RENALHGKML PLKIMDTFGI EERDVDTVWS EAYIRCVLKG CCTNTTLSEA
RGWSQYGMPQ CDPTQHKGPD AVIFVLKIVE SDPAMMQVLS RIEDVIVRSS DVKRVPIFIA
FTFLNKLSSS AKERLREHAV AQIKQAGLKF IDLQRVFFLP TDNNGQTSCE VTKPVFAMLH
DAVRVIQSQE PEPLGFHYWL YAQWQLSTWS EVFYTTFSVV VIAAALLAGY VALKPAQQPQ
NLKPQQQEGG TRKGRHGGGD DDDKNDDDRD PPAAQVTQDA RNGVKGSEGE KEEEGLSART
SAATGSANDR QGQGSTKHGS TTPDSGTEET DNGAHEEGQD TTRAATAGKT CDLGMD
//
