ID F2UJY9_SALR5 Unreviewed; 1886 AA.
AC F2UJY9;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU363044};
DE EC=3.6.4.12 {ECO:0000256|RuleBase:RU363044};
GN ORFNames=PTSG_08535 {ECO:0000313|EMBL:EGD77438.1};
OS Salpingoeca rosetta (strain ATCC 50818 / BSB-021).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Salpingoeca.
OX NCBI_TaxID=946362 {ECO:0000313|Proteomes:UP000007799};
RN [1] {ECO:0000313|Proteomes:UP000007799}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50818 {ECO:0000313|Proteomes:UP000007799};
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "Annotation of Salpingoeca rosetta.";
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- SIMILARITY: Belongs to the helicase family.
CC {ECO:0000256|RuleBase:RU363044}.
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DR EMBL; GL832978; EGD77438.1; -; Genomic_DNA.
DR RefSeq; XP_004990326.1; XM_004990269.1.
DR STRING; 946362.F2UJY9; -.
DR EnsemblProtists; EGD77438; EGD77438; PTSG_08535.
DR GeneID; 16070882; -.
DR KEGG; sre:PTSG_08535; -.
DR eggNOG; KOG0987; Eukaryota.
DR InParanoid; F2UJY9; -.
DR OMA; CNGTRMQ; -.
DR OrthoDB; 1219580at2759; -.
DR Proteomes; UP000007799; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd18809; SF1_C_RecD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR010285; DNA_helicase_pif1-like.
DR InterPro; IPR025476; Helitron_helicase-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR049163; Pif1-like_2B_dom.
DR InterPro; IPR001878; Znf_CCHC.
DR PANTHER; PTHR45786:SF82; ATP-DEPENDENT DNA HELICASE; 1.
DR PANTHER; PTHR45786; DNA BINDING PROTEIN-LIKE; 1.
DR Pfam; PF14214; Helitron_like_N; 1.
DR Pfam; PF05970; PIF1; 1.
DR Pfam; PF21530; Pif1_2B_dom; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU363044};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|RuleBase:RU363044};
KW DNA recombination {ECO:0000256|RuleBase:RU363044};
KW DNA repair {ECO:0000256|RuleBase:RU363044};
KW Helicase {ECO:0000256|RuleBase:RU363044};
KW Hydrolase {ECO:0000256|RuleBase:RU363044};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU363044};
KW Reference proteome {ECO:0000313|Proteomes:UP000007799};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00047}.
FT DOMAIN 81..96
FT /note="CCHC-type"
FT /evidence="ECO:0000259|PROSITE:PS50158"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 57..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1037..1070
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1097..1194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1346..1422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1816..1835
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1425..1456
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 57..74
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1051..1070
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1886 AA; 208433 MW; 117B90FE3AD986FE CRC64;
MPVLWKPRSQ RTDVPLGEKA GNATRGAPGS KLWPCSSNWG IGLQAVVMVT ASPLASVHAQ
PQQRQQQQQQ PPSRAGRTRE RRCGRCGQTG HTVTTCSLSA NRMDDVHLLP PLTRECPYCG
ALLFDGQRRE DGSETSSFCC GNGRVHLEPM PAPPAPLRQL WEDRGERGRI FYDYIRLFNN
ALALASARAS WVRAERGWNP HLIIQGSLHH CIGSLLPAEG EEPQFAQVYV YDNVGQATAR
RLLDMRQRIA AGTSVPDSIC ANILTTLHDM LVDCNPYVDA FRDAASAALA SSGDDAVPDL
QLVLNSENRP ADQHARRYTS GNSEEVALLC PDDQVAQRDL VVYPRDGGIQ FINETHQAWD
PLHFVLLFPD GTPGWRIGVP LRVPPSLGGD QRRPDQCGGA VVDAEDVMGL GGDGSAARHV
STRQFYVYHL MQRSQCNYLL RAGRLTQEYI CSAFYRVEYL RLLYVRQHQA ELRSAIYQNL
VDHSGEDDAD EQQLGRRVVL PSSFLGGQRH TKERFHDAMA ILGEYGKPDL FVTFTCNPAW
PEITRELRGH ERASDRPDLL ARVFHAKLAA FRIDIEHGHV FGPTRAFLYA IEFQMRGLPH
AHCLVWCAQP LQGPSDIDRF ISAEIPDPAT DATLHALVTH HMLHGMCGSH NPSAPCMTPS
GCQHDFPKPL CSETSWRDEM YPQYRRRGVR DGGMAVSRVI NGEAVTVDNS WVVPYSPALL
RRYQAHINVE VCGSVRAIHY VFKLFGYEIY YRRPSVQRLT LHLPLRQSVL GTEAQLASVA
RSGEQPHTPL LAFFELNCHH GDEPLRLHPT LTSKDLTYAE LPKYFVLERS RGRSKWVQRR
RPQATPTLGR VCNIHPGAGE LYFLRILLHT VRGPTSFEDL RTVDGVVCPT FKAACCELGL
TRDEHWQAAI TETCNAYGPG RAREIFARIL YMCQPPRPIN IFDACWRLLT ADYTTALRRQ
GRFVPDEVLK AWALAAIADA IEPEGHTLDS FGLPSRDDLR RTLGVAGQPP APPFRGGGCH
PSRLGRPPAA MQLQPQPPVV DGPSPVPIAE DGRTVREDGN DHDEPVQRRV ERKLSVLLPS
QRTVVQHILD AVCAQRRRHE RHLQRRSGAV RGGARGRGRG GGGARGARGA RGRGGARDVR
GGGGARGRGR GGGGARGARG ARGRGGARDV RGGGGARGRG RGGGGARGAR GARGRGRSRH
VAFFLDAPAG TGKTFCLNLL LEVLGDLGLK AMAVASSGIA ATLLTGGRTL HSRFKVPINI
PQPRPFNIDA SSELAAELRD CSLIVWDEAP LANRVLLESL NLTLRDLRRD AAPFGAASLL
LAGDFRQVLP VIRKGSLSAV ASFHPTSTLP QRTRSRHRGW TITTPPTTPT PTTTTTTTTT
TTTTTPTTTT PTTTTTTTTT TTTTTTTTTT PTTPTTTTTT PTTTTQQQQQ QQQQQQQQQQ
QQQQQQQQQQ QQQQQQPNMT PREFVDWLLR LGEGREPDCR TPAAIEADAC NGRRSTRVRV
PPHMRIGMSL DAIIAAAYGE NFQDCHRAAI LAPTNAIVDR LNDQLTDRFP GEKTVILSSD
EVDPTSPASG TVSPETLNGF TACNLPPHRL VLKPGMPILC LRNLSPTTGL CNGTRLRVIA
VHGNSVLFVE ILTGPSAGST VVLPRVPLSA PEDMFPFPWT RLQFPVKPCF ACTVNRSQGQ
TLDRAVVYLE DDLFGHGQLY VAASRVKHPS RLFFASPLPH VANVVYTEAL GAPALPAASQ
QQQQQQQQQQ QQQQQQQQVE LQQEQQQQQQ VELQQEQQQQ PQVELQQEQQ QQQQQQQQQQ
QQQQQQQQQQ QQQQQQQQQQ PGSISGSGVR CKRHHHRHPY LRWPWHIPAD DQERLALLAG
VDTYNLIASI ALQHAPNAFP RLTVGE
//
