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Database: UniProt
Entry: F2ULG4_SALR5
LinkDB: F2ULG4_SALR5
Original site: F2ULG4_SALR5 
ID   F2ULG4_SALR5            Unreviewed;      2637 AA.
AC   F2ULG4;
DT   31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   31-MAY-2011, sequence version 1.
DT   16-JAN-2019, entry version 36.
DE   SubName: Full=Cardiac ryanodine receptor {ECO:0000313|EMBL:EGD77963.1};
GN   ORFNames=PTSG_09597 {ECO:0000313|EMBL:EGD77963.1};
OS   Salpingoeca rosetta (strain ATCC 50818 / BSB-021).
OC   Eukaryota; Choanoflagellida; Craspedida; Salpingoecidae; Salpingoeca.
OX   NCBI_TaxID=946362 {ECO:0000313|Proteomes:UP000007799};
RN   [1] {ECO:0000313|Proteomes:UP000007799}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 50818 {ECO:0000313|Proteomes:UP000007799};
RA   Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA   Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q.,
RA   Gargeya S., Alvarado L., Berlin A., Chapman S.B., Chen Z.,
RA   Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA   Heilman E., Heiman D., Howarth C., Mehta T., Neiman D., Pearson M.,
RA   Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S.,
RA   White J., Yandava C., Haas B., Nusbaum C., Birren B.;
RT   "Annotation of Salpingoeca rosetta.";
RL   Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; GL832980; EGD77963.1; -; Genomic_DNA.
DR   RefSeq; XP_004990026.1; XM_004989969.1.
DR   EnsemblProtists; EGD77963; EGD77963; PTSG_09597.
DR   GeneID; 16070578; -.
DR   KEGG; sre:PTSG_09597; -.
DR   InParanoid; F2ULG4; -.
DR   OMA; DINIRTC; -.
DR   OrthoDB; 94996at2759; -.
DR   Proteomes; UP000007799; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 3.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50919; MIR; 3.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007799};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:EGD77963.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007799};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2273   2291       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2303   2323       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2359   2384       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2404   2424       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2475   2499       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       89    139       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      209    276       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      283    331       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     1665   1685       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2637 AA;  294635 MW;  BB3EB9900DEF83CB CRC64;
     MALFGGASQG AGRTALCNGD FVSLFVEELK GFASVDILST REVTVYQGDT DSAFDGSTST
     KSSSETATAP NFEQSCVFQI KAVTDLPEGA SLKYGDVVRI IHRSTQRSMT RQNRAVNGKH
     AVALENTDRA AAHFRLLPRF KIRSVGEPVL LNDQVIFQNE VVIEGNRTYL MTDRPEDSPK
     VLMECGSSKT TGIRVRLFAA YNVSSKAFVH VLKGGDFVRL FHHEANGFLV VARHIGTGDA
     HDFLGRDNTV CLRTLAVGRS PDEYHDASSI WQVELEDTQR RGGRPVLWTD RVRLKNVLTN
     EFLDVRTTSS TGAMAPTADK GSSNLFSFVQ STHSAQEGDA PATALLSRQE DLRIPYHTFF
     FLRGSGNPEV TDQFLHVDSE HYAVEEDEEG DDTGQSSTFA QTVLIATHDE DAFSLQSVHQ
     QDIRDFYYAL GHVKVLTRLA ADDVLTDVTN PVHADLYKRA RRSIHALIQF CSEDKIEDDE
     DVVGRANTLH QNILFDLQVQ VPLMKVVSLP FHGAHCAEWG KGWRERLTQT QYRHYNKLAR
     DVYRLISYLC RENVHIGLMF ANAHLTAMIN QCRLIGYLDG INWDIADAID EMFKDNTILL
     NRVTKQSIET YLSLIHEAHT TTALEQYLRL LAALCSVDGE AITSTQASIR DLMLVPGAPS
     ADVLPSIANG PSGMRITARV LTPGKPFRAW STVTLPLQEY LKDHDNLEYF DATLELFAQL
     CLEGNCQGEL RAAARTPFPM IMGALKSQLP PHVKARFCTL LVNLYIDGDD LPDVDHSNRR
     WQDLANHKSH AKLKTAAVQL FDVDEVVNWV EAYLSQNGLL TYNHEYHSAA NSKKPEMIAL
     KQDELHRNML TEQVVHVALA LVNKGLYWDA GSRKRLVRLL LTLLVRTHPG ENDDLSATSS
     LDVVMQAKTL VCRALGACMD ANLDEVVTEL LTAFKKEYLA HKHKHIEAHA DDRALHEVSL
     IQHNGDHRHF FETDGLSQQQ IVHLLLALTT YPSDGLRVAA LNLLLRCFNV KGSVLARLSD
     VVVIADSKDE AALEKLEQLL LTLKHEDHDD LHTAAAHMTE EIEWMCSQCI TVNGTLAADL
     LAPGDSSSSS SKAGRRKRKG VSGPRLPWRK PGVSIEPHHA HQEMMRNANA HKAVLHILHH
     HLSGADLKTA LKDDRARDLF AACFEFLAFF CLHNKHNQEL LGHAHDISFF VHACSYGIHA
     EKVLHRILEG EPDLVQEHVV DEGKVDRLIA DLIKEPRCRN VDFLKLMEVI VAPTGTPSRE
     LQDLVGEHFL QAEEKSHLFE HELGSSHFIS FIVSTYTKTG GRGDDEDDNG TSAQPLSARE
     HDLRDFFEQL LSFYAVTAHG NQGTAAHVAK HVPLAELAQP FIDGVTLPTA TKSRLLTLIR
     DVYLLHGTDE DGDGVVDDVD AEDFGFVSAA AKQETCVRLC GPLANELRAI DKGWKHKPSK
     VRAALDRYAF MTLLPLAADL LRIFVEEHGS VPAERLEEEA VSLVAECVRF LKHRRTVTFE
     SPHYLMDHEY RVLGGHVTGE LLKSTLLAQQ DALLVNVQTE HTWYDETEAK EARTAAARST
     ALSMGSKHGS SKRHAFSIDS FAATHSKRGG GGHTRGGGKA PRKVMPVEKV KTEGERIQEE
     LPFFVDQVRE TFNHGFSQPH LPWMSFLSTE YNFQPFWALV GILQADLLED RLHEEEKEAE
     EAAQGGMLGA DGERSGVQSR QGSRPELQRT TTAAAAARSG TFRSLRNRRR SRVHGESMQM
     NPINLVDVNV DINIRTCLEN VMTHFEEAGD HEHHHHEFEE EDEEEAIVGF LAAMSCALTC
     VVDPKTGRVY QELDDEDNEE AKAAHEAAIA TVGRSLNSLG LPDMVLFLLS SNHRCTVLMA
     AQLGWLMLDA TPHVFEAKAA AALMESSIEG GSTLARRQHQ QQQERLLSQW AFHDAFESGP
     MGRRALAAIQ RHLQHMQELL FKREHEDPLD RLRRDQDVEN LDVAIVHEPI LLFLRYLNAS
     DDSEDIPDKD VFHSLTLYVL EAAASLSIWC ESYGVVDNGH GDWVQQDGYD VDVDTEHMHA
     LVKSFDLCNA LDVIDECCEA SILFLLLGVL EGRREGDVVL DMLCAALFPE PYLTRDAHFT
     QSAFFRLLDG HSAAAESDAN MHVREAALQR VAASPHTAHF FDHDVALLYY TVLRILGEQA
     ENYCIRVTHL LNTWEQHSPH SHNARDSVGR IELLRDGELQ PVYFQVPAVV HDTKDKLQVR
     QLRTQMINGT VLENPEQKMQ SFFGSVDFLM NVMNFEARVA RMGVSYVLGH QRFLLPLAFI
     LAAIINIWVI FDLGDDGFPH SVVRVLAIAH AVVSMLILLG QSLSPLYVDW QRWQEAAEGR
     SLLGKALAFP LFWSLQASYP YYVVYLAMSV AGIFQFKLFC FHLFDLVLRV EVMNLVLRAV
     KQNVSKLLGT FLLTFFIIYA FMLVGRDAFG GTYDFADAPA TCAPGTPLVQ CLRDHLYYGF
     YSSPVFAPAD ADVGLFVYSL LYFMVVVLVM AAIVSGIIID SFGEYRAETE AIAAEKESRC
     FVCNFSHDRI QAAHKGGFEA HIASDHNVWN YIWFLMRVLE KREEHKPLTG VEIEAVRHWD
     TSKDLTAMMP VNRALCLEAA SEDVTLDQVL DVVKQVAITA ERSLQLLLAS AAVPASS
//
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