ID F2UNA3_SALR5 Unreviewed; 1133 AA.
AC F2UNA3;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=PTSG_09835 {ECO:0000313|EMBL:EGD79108.1};
OS Salpingoeca rosetta (strain ATCC 50818 / BSB-021).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Salpingoeca.
OX NCBI_TaxID=946362 {ECO:0000313|Proteomes:UP000007799};
RN [1] {ECO:0000313|Proteomes:UP000007799}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50818 {ECO:0000313|Proteomes:UP000007799};
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "Annotation of Salpingoeca rosetta.";
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; GL832984; EGD79108.1; -; Genomic_DNA.
DR RefSeq; XP_004989193.1; XM_004989136.1.
DR AlphaFoldDB; F2UNA3; -.
DR STRING; 946362.F2UNA3; -.
DR EnsemblProtists; EGD79108; EGD79108; PTSG_09835.
DR GeneID; 16069737; -.
DR KEGG; sre:PTSG_09835; -.
DR eggNOG; KOG1264; Eukaryota.
DR eggNOG; KOG4229; Eukaryota.
DR InParanoid; F2UNA3; -.
DR OMA; AMIFRES; -.
DR Proteomes; UP000007799; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00124; MYSc; 1.
DR CDD; cd00173; SH2; 2.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR46256; AGAP011099-PA; 1.
DR PANTHER; PTHR46256:SF5; MYOSIN MOTOR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00017; SH2; 2.
DR PRINTS; PR00193; MYOSINHEAVY.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00252; SH2; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS50001; SH2; 2.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW Reference proteome {ECO:0000313|Proteomes:UP000007799};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2..750
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 885..974
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 1030..1126
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 616..638
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT BINDING 96..103
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1133 AA; 129156 MW; 586AE4E259B1AF80 CRC64;
MAEKNDLALE EELDEDMLTN ILKERYQQRI IYTYVGDILI AVNPYEDLSL YTAEQTATYC
NVANKADHPP HIFAIADNAF GEMMRNHQRQ VAVISGESGA GKTESTKLFI RHVMDVSARG
ILNTATPATR TRHPLEEKII QLNPILESFG NAQTVMNDNS SRFGKFVELK FNESGVVQGA
SLSHYLLEKA RVVKQGPGER NFHIFEQLLS GLSQDERAEY GLASQTEYSY LSSRVNDTEQ
LTNEFSEIAS ALNKVGFTSQ EIGDIHRVLA SILLFGNLEF DDAESDGAVV TNEEVIEAIA
RNLGVERKVL EKGFMTSKIK VMGDIIVRPL NPSKCQHSKN AVAKALYDRL FTWTVTRLDM
MLCPTEATTA VHSIGILDIF GFENFTFNGF DQLCINLANE SLHHFFNQHI FAAEMKAYED
EEIDGMSVMF SDNVHVLNLF YENPGVLHIL DEQTKFAQGN ASALVKTLKE QLADHALFEV
KQGDLSFEIK HYAGPIAYEI DGLIEKNKDP LPEAMASSMS TSTNALVSLL FHHNLVSATR
KGAARTRARE LTRELSRQTT RRITRAATVK HKSVKKQAAD LGFENPDTNK GLLGRIARTF
KRPNVETVSS QFKQSLDALM YKMSLCSPHF VRCIKPNPNK MPRQYEDALV LKQMQYTGML
QTIKMRREGF SVRMSFEELI SSYQGIVFKF SDKMKYTKGV AEELLIKCAE KQEANRQDQK
LTSSLSGWLI AKTKVFLKYW HPDVLDALLL DSKIAAVRIQ SWVRRFLAQK RFRPRLQAYR
DQLAMAVSFL HDMKSRGHQT FLALETLVEE EERRGPEDLG IATPVDKKKE NKEKRKMLKE
AHKDVDMRKL RKTHAKEQKD VLRWWKKYEK PRRAHLDAHG RVHTWFHGLM SRGEAEEFLF
EEPDGTFLIR VSETSRNYAI SVKVNGRCKH YRINTGVGYQ VLGSDEDFGT LEDLVDFYGE
EPLSPANDRL QRPLDALHDL RLGFGNANMA NPVFPTGGRS MKLDGNARAS TSQRLRREDY
LRNPKQPPSW LRGKLSRSEA ESELKKRGLA SGRFLVRERE VGVDSVTFVV SYTHDRRFFH
HLLVRDIDED WTLNDRPLRV RYLDDVIAKF QGRKYPGLAT RLESDAPEPV KRA
//
