ID F2UQ41_SALR5 Unreviewed; 677 AA.
AC F2UQ41;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
GN ORFNames=PTSG_10694 {ECO:0000313|EMBL:EGD79709.1};
OS Salpingoeca rosetta (strain ATCC 50818 / BSB-021).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Salpingoeca.
OX NCBI_TaxID=946362 {ECO:0000313|Proteomes:UP000007799};
RN [1] {ECO:0000313|Proteomes:UP000007799}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50818 {ECO:0000313|Proteomes:UP000007799};
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "Annotation of Salpingoeca rosetta.";
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; GL832988; EGD79709.1; -; Genomic_DNA.
DR RefSeq; XP_004988659.1; XM_004988602.1.
DR AlphaFoldDB; F2UQ41; -.
DR EnsemblProtists; EGD79709; EGD79709; PTSG_10694.
DR GeneID; 16069195; -.
DR KEGG; sre:PTSG_10694; -.
DR eggNOG; KOG4229; Eukaryota.
DR InParanoid; F2UQ41; -.
DR OrthoDB; 1022106at2759; -.
DR Proteomes; UP000007799; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR14336:SF8; DUAL ADAPTER FOR PHOSPHOTYROSINE AND 3-PHOSPHOTYROSINE AND 3-PHOSPHOINOSITIDE; 1.
DR PANTHER; PTHR14336; TANDEM PH DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007799};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 81..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 112..131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 137..162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 182..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 224..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 265..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 546..645
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 328..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..366
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 677 AA; 75759 MW; 058106CE860BF876 CRC64;
MAVRSVAAIA AAVVAVGSRV IAAHAAAHNG MWLATDDDDG RGGFEGHDHN PLGADSDSML
HSDPANCTVM CPTLMQSPQQ WPLWVVMSMY AILLVLAVAV MRLSPLRSSR MVLLSMQVCL
LVIRIFCYIV KLPWTKLAVR IVIIMLPIYL QFITFLLVAT YILRMFVTIY VRYERRDRWL
TVLNWVVVSV ALLILGMDVG LFVYCSQADD PCGNVKEGFD HNLALFSALT FGFITLVLGA
SGVLARRVIR KCRNDSEESK RMLRIIFRVL VMYTCVFAGR SIWAITYAAG ANRAQDYIAH
LSRTNITSFY ATSIAFFGTF EFGFGDDLVE DTNPPPPPPV PRRRASTGST RSNNSDTSTS
SNDSVFDNVD EESKPTARVV SILGQTGVGK SHLATWEVYG KRMGPYDESE TIREVISVPP
TTTTPGCTLI ELGHDQVPEE TRVEHYEHEI DNSNGFILMY DTTRRETYDL VKWVLTELMQ
RRSKIDWSCV VIANDFNASP ECKPVVDPAE AQDLCDSFGV TFMQVQDICQ PEHKPLAQVL
KGIGGSHSMV GYLDKKGGGS SVLGRKNWKR RWFVLDDTML TYRPTPDSPG VKGRIAIDDM
EAVRDGDADK PQQFVLVAKK RELVMQAPTP DKKMMWVNKL TDVIQKRGRF KRSLFMSRRF
TGTQRFSQSS QSSHSHI
//
