ID F2UQK6_SALR5 Unreviewed; 3100 AA.
AC F2UQK6;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=[Histone H3]-dimethyl-L-lysine(36) demethylase {ECO:0008006|Google:ProtNLM};
GN ORFNames=PTSG_10194 {ECO:0000313|EMBL:EGD79911.1};
OS Salpingoeca rosetta (strain ATCC 50818 / BSB-021).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Salpingoeca.
OX NCBI_TaxID=946362 {ECO:0000313|Proteomes:UP000007799};
RN [1] {ECO:0000313|Proteomes:UP000007799}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50818 {ECO:0000313|Proteomes:UP000007799};
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "Annotation of Salpingoeca rosetta.";
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR EMBL; GL832989; EGD79911.1; -; Genomic_DNA.
DR RefSeq; XP_004988532.1; XM_004988475.1.
DR STRING; 946362.F2UQK6; -.
DR EnsemblProtists; EGD79911; EGD79911; PTSG_10194.
DR GeneID; 16069062; -.
DR KEGG; sre:PTSG_10194; -.
DR eggNOG; KOG4297; Eukaryota.
DR InParanoid; F2UQK6; -.
DR OrthoDB; 3035244at2759; -.
DR Proteomes; UP000007799; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00033; CCP; 6.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 6.
DR Gene3D; 2.60.120.650; Cupin; 2.
DR InterPro; IPR003347; JmjC_dom.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR PANTHER; PTHR19325; COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR19325:SF573; SUSHI DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF08007; JmjC_2; 1.
DR Pfam; PF00084; Sushi; 6.
DR SMART; SM00032; CCP; 6.
DR SMART; SM01411; Ephrin_rec_like; 4.
DR SMART; SM00208; TNFR; 2.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 6.
DR PROSITE; PS51184; JMJC; 1.
DR PROSITE; PS50923; SUSHI; 6.
DR PROSITE; PS50050; TNFR_NGFR_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007799};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2951..2973
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 119..343
FT /note="JmjC"
FT /evidence="ECO:0000259|PROSITE:PS51184"
FT DOMAIN 674..712
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 674..712
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 778..836
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 837..894
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 895..956
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 957..1016
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1017..1072
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1156..1214
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 199..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2334..2354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2926..2945
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3035..3100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..243
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3100 AA; 327400 MW; 0F12B10F91F7254C CRC64;
MAATRLSNEQ QQEDKQPSLA FHDFFPSTDT ATFFDSIYQH DTFVDSQPHG NAPQLLSPTM
RDVVAPLADP HALCQHHFSL DEEQRKPKSK HTAPFQIKEQ GETRQVSSCK QMEDELAAGA
GLLIRYEDLV DSPAQDHVKQ LQDGVRDVFG TESTVHLYHA TQNESRALMP HTDPYDVLVI
QLHGSKRWTT CIPDAYVSDT DTNNDGSGTN AEDDDNTNTG TGDHGASASA SASASSSFPS
HHGTRARPSE AETIKHFNPA QLGQLQEIRR QKQEGCTRYE DRDLRGMRCT EFTLRAGDTM
YMPKGIIHFA LSGEEGSSHL TISLERKGLA WADALMHAAL SGSDIVDTRR SLVTGENTVQ
SLLQQHGDGS AAGGERDEVK AFVASFQSLC REVGPDVLET YTKANDLDAF LNADGIGALV
ERVCSEESAT AVVEQLCARG KMPVDVTSPR FRKMRVPQMA RTRRNTVTTS YNCTSGCDEN
CNRFTCQCDE GCTTTCNEGC TDCNESCDGQ QCDSSCDSSC DGETYVCRAI DSLCNTGCDA
SCDSTQCYGS CDICIGCTSG CDDSCDKSCD ASCDLVVFSC DSGCDQSCDS GCDDNCNNCY
AGCDSNCIPT DCDADCDGTC ACDTSCDGPC NSGCSTTCNT GCDGCPDLSS CTGSCDEGCS
CNPGFAGSGQ ACEACPTGTY ASSSGQSTCT PCSSCPSGQY RVNCGGSSAG TCGACHACPP
GEQRVGCEGT NAGTCAACPS GTYKSTQGNG ACSSCPACDP GFTRVECQGT SAGHCVGTTC
DVPPSSSNTA VSVSNDGIYP STATYTCSAG YELQGSNTLT CSVSGDWEGD VPQCVGVECD
GIHVDNGIVT PSGTINYPKV AAFSCSTGYV LMGATSAQCQ ADGTWSSPAP TCVGRLCTLL
DTPNHGSVSY TNNRQYPSTA TYTCQAGYEL SDTGDAQRSC IASSGGFGGT APSCVGVLCN
PLGDPQNGHL RLSSTPARYP ATAEFSCVPG YELVGQAQLS CKTDKTWSAP APTCRGVLCT
APSIDHAQVS ATSGRYPADA SVTCAPGYGL VGASTLSCRT DGTWGELPSC QLCPANSYAP
SPTQPCASCP SGTSTNGQTG ATKCECIAGH EPSGDGSTCV PCQANHFKPD FGSVSCQQCQ
SGFQTENGDF TRCVGVPCDP VRDIENGDPE NTMMHRYPAT VSYECDTGFQ LVGDVSSITC
QTDGTWSALP SCTYICGDDL VVDGEECDDG GHNKTVGCSS TCQLERLHSC VDGSTAACVY
CNFTSRPERL VLACDDPMLD TKVQTWADAT GNAEVLDHEH CGDPSLSYVA GKPRGTVPGC
YHKVYAFTAV FDGGQVMETV AGVVRVYDDT KPTFQDPPSS TTADCHSVPA FADVSASDTC
MTSSPAVSKQ EVRTDGACPY AYTLTRTWTT QDACGNENAA TQVVTVQDVT KPTFTTRPTD
RVLECSADVD ADIEALRMKH VDAAASDLCS DTLSFETVET ARDLSGCGST GQVSLKVTVT
DECGNPQEET VTVDVVDKTA PVPVNVPADV TVECSAIPPI ADDVHARDAC GLRRVNATAS
EERQDGPCPH SYDLLRTFTF VDACDNPVSR TQRVTVQDTT GPVITRDADD LELECSAERN
DATIAAWLAV NGGAQAMDAC SGVHTLTWTH DYDPQYYEVF PGGCSVGTGQ VLVTFTVADE
CGRTSTVNGS IKIVDTREPA FVAPLPPLTG ACDAVPQATV PQAYDNCTGE VTPTQTTTRM
DGDCPHQYHL IHSWVAEDEC GWTTTTQQTV TVTDAAAPTI TKQSADRTVE CSVADNEAQL
DAFLAEHGGA QATEVCGGVT WLYSDVDTVL DVAQGASGDV VKQDGCGTTF AATAHFYAVD
ECSNAAKTTA TFTVQDTLAP VLDTPPAASI DASCDAVPAL RNISATDMCA GALVAVASEE
RLDGRCTHTY TLSRTWMVQD PCGHMTTKSQ LVHVDDSAEP VITKEAEDLV VECNAETDSV
IAAWLEAHGN AAAADACDRE LTWQHDFESV KYLLQYGCGS NAVNVTFTVM DDCGNAAETQ
ARVVVQDTTA PFFTQLPSDD RAECDPTTNQ NTLDVFLAAY GGARASDVCG GVVGQDVAWS
YAVDLQTVCG NAYDSVVTFT ATDHCGNNVS ATATMAFEDT QKPVIKLRGA DPQLAQVGFP
WLDPSVDLAA DRCHQELTPF VEVVNPPNTT QVGNVTVFYR VEDACGYVGL VNRTVYIRDT
LPPTLEVLGA KRMYVSAGSL FLDPGAAATD AYSRGTDIVT HAFDGGVDIG SVRNAALDGN
RTSFTIVYRA ADLSGNTVLR YGRHVRVLPP PSPLLPATAQ VSLHFSRSIV LSAEAGDDAP
SSGEPTPSEG SPAFTYTRLV TPVADADSGS VTLSVFEAEG LSTLLGGEVH GVQVEDPSTT
LKEVAVVLGP VSPDVVASAR ASDAIEAMST PVRVRSFHGS VRTASGQCSG KSGVEDSLAR
VGRRLVSAQC DGCLCIFTTN DPARTLTSSV AFDAMALEQT VQHLVTVQSS TGSALNLVTL
RLRLQQLGVV PVRLVHKNQG QAQVMFVART PLPSHEDLDQ IARVTLVSNQ PIVGTRITAD
IHSDTSNVTI LSRLYALGIV PDSMQLVSSE NGTSTTLTLT TNNDVTNRAE RELADNTGWI
HSLLSISYVY PGSIEEPLWP FNYTITGRSN VTQDDVRDAI TTTLTHADAV FVIRGCEARV
CTVSTNTPLL HTTLQALRGQ GAIFEAALTV DVSIESELIS SLEENLSLLL PYPANRISVF
RSSAGPQHQQ QRRKRELTDI AVTVSFTAQE DASLVTAVPE EGYEVPRSRY LLRFRVKNAA
SSANAREKAL VALNALSIAA VDVTAAGDQV TAVTVSYESD DRLDQFRAHA NIISSSVLQQ
VSIDSPLSIT DAVAATTDLA NSGELYGVVH GRKLVVVSTT STFNPNPTTT TTTTNPSVTV
QPGASTSGGE AWQISVGVIG ALLLIVVLVA VILRHRRRQA KRTLANTTVL QHRTVSYENP
AYSGSMTTTE NPYTMYDDLG TIGDAQSTDY AELPPPSVRN GRLLSNPLYE SGPTLSDDGD
GYLSVDGTGA ESSPSAYEDD VDDGYMVVRG TGLDDGKTDA
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